Serum creatinine =< 2 x ULN Serum creatinine =< 1.5 x ULN Serum creatinine =< 2 x ULN Serum creatinine =< 2.5 times ULN Serum creatinine =< 1.5 x ULN (for treatment phase) Serum creatinine ? 2.0 × ULN Serum creatinine =< 1.5 ULN Serum creatinine =< 1.5 x ULN Serum creatinine =< 1.5 x ULN Serum creatinine < 1.5 x ULN Serum creatinine =< 1.5 x institutional ULN Have a serum creatinine ?1.5 × ULN. Serum creatinine =< 1.5 x institutional ULN Serum creatinine =< 2.0 x ULN Serum creatinine =< 1.5 x institutional ULN Serum creatinine =< 1.5 x institutional ULN OR Serum creatinine < 2.5 times ULN Serum creatinine =< 1.5 x ULN, OR Serum creatinine =< 1.5 x institutional ULN Serum creatinine =< 1.5 x institutional ULN within 14 days prior to start of protocol therapy. Serum creatinine =< 1.5 x institutional ULN Serum creatinine < 2 x ULN Serum creatinine < 2.5 times ULN Serum creatinine =< 1.5 x the ULN Serum creatinine =< 1.5 x the ULN Serum creatinine =< 2 x ULN Serum creatinine =< 1.5 x ULN Serum creatinine =< 1.5 x ULN Serum creatinine =< 1.5 x ULN Serum creatinine =< 1.5 x ULN Serum creatinine =< 1.5 x ULN Serum creatinine < 2 x ULN Serum creatinine =< 2 x the ULN Renal: Serum creatinine < 2.0 x ULN or creatinine clearance ? 50 mL/min/1.73m^2 for patients with serum creatinine levels above 2 x ULN. Serum creatinine =< 1.5 x ULN Serum creatinine =< 2.5 X ULN Serum creatinine ? 1.5 x ULN Serum creatinine =< 2.5 Serum creatinine ? 2.5 Subjects above specific amount of serum creatinine. Within 7 days (+ 3 day window) of enrollment: Serum creatinine of =< 1.5 x institutional ULN Serum creatinine =< 1.5 times ULN (For both cohorts A and B): Serum creatinine =< 1.5 x ULN Serum creatinine =< 1.5 x the ULN Serum creatinine =< 1.5 x ULN Serum creatinine =< 1.5 x ULN OR Serum creatinine =< 1.5 ULN Serum creatinine =< 1.5 x the ULN Serum creatinine > 1.5 ULN Serum creatinine < 1.5 x ULN Serum creatinine < 1.5 x ULN Serum creatinine ?1.5 x ULN Serum creatinine =< 1.5 x ULN Serum creatinine =< 1.5 X ULN Serum creatinine =< 1.5 x ULN Within 14 days prior to registration: Serum creatinine < 1.5 x ULN Serum creatinine =< 3 x ULN for age Serum creatinine =< 1.5 x ULN Serum creatinine =< 1.5 x ULN Serum Creatinine < 2.5 X ULN Creatinine serum levels ? 1.5 x ULN Serum creatinine > 1.5 x ULN Serum creatinine =<1.5 times the ULN or Serum creatinine ?1.5 x ULN Within 14 days prior to study entry: Serum creatinine =< 1.5 x ULN Serum creatinine =< 1.5 x ULN Serum creatinine =< 1.5 x ULN Serum creatinine =< 1.5 x ULN Has serum creatinine < 1.5 × ULN Serum creatinine =< 1.5 x ULN Serum creatinine < or = to 2.5 x ULN Serum creatinine =< 1.5 x ULN Serum creatinine < 2.5 times ULN, OR Serum creatinine =< 1.5 x ULN Serum creatinine =< 1.5 x ULN Serum creatinine =< 3 x ULN for age Serum creatinine < 1.5 times the institutional ULN Serum creatinine =< 2.0 x local institutional ULN Serum creatinine < 1.5 x institutional ULN Serum creatinine =< 1.5 x ULN Serum creatinine =< 2.0 Serum creatinine < 2.0 Renal: Serum creatinine < 1.5 x ULN or creatinine clearance ?60 mL/min/1.73m2 for patients with serum creatinine levels above 1.5 x ULN. Serum creatinine concentration < 1.5 x ULN Serum creatinine < 1.5 times ULN Total serum creatinine ? 1.5 × ULN Serum creatinine < 1.5 x ULN Serum creatinine ?2.0 x ULN Serum creatinine =< 1.5 x the ULN Serum creatinine =< 1.5 times the ULN Serum creatinine =< grade 1 Serum creatinine =< 1.5 x ULN Serum creatinine > 2 x ULN Serum creatinine =< 1.5 x the ULN Serum creatinine < 2 x the institutional ULN Serum creatinine =< 2 Serum creatinine < 1.5 x ULN Serum creatinine =< 1.5 x ULN Serum creatinine > 2.5 × ULN. MDS Cohort: Serum creatinine at least 1.5 × ULN Renal: Serum creatinine ? 1.5 x ULN, or for patients with serum creatinine > 1.5 ULN, creatinine clearance ? 50 mL/min. Serum creatinine =< 2 x ULN Serum creatinine =< 2 x ULN Serum creatinine > 1.5 x ULN Serum creatinine ? 1.5 x ULN Serum creatinine equal to or less than 1.5 x ULN Serum creatinine < 1.5 times ULN Serum Creatinine ? 1.5X ULN Serum creatinine < 3 x ULN Serum creatinine =< 1.5 x ULN Serum creatinine < 2.0 x ULN Serum creatinine < 1.5 x ULN Serum creatinine ? 1.5 x ULN Serum creatinine < 1.5 x ULN (within 7 days prior to registration) Within 4 weeks of administration of study therapy: Serum creatinine =< 1.5 x ULN Serum creatinine 1.5 x ULN Serum creatinine =< 1.5 x ULN Serum creatinine =< 1.5 x the ULN Serum creatinine ? 1.5 × ULN Serum creatinine =< ULN Serum creatinine < 1.5 x ULN Serum creatinine =< 1.5 x the ULN Serum creatinine > 1.5 x ULN Serum creatinine =< 1.5 x the ULN Serum creatinine =< 1.5 x ULN Serum creatinine ?1.5 x ULN Serum creatinine =< 1.5 x ULN Serum creatinine ? 2.0 x ULN Serum creatinine =< 1.5 x ULN Serum creatinine =< 1.5 x ULN Serum creatinine =< 1.5 x ULN Serum creatinine =< 1.5 X institutional ULN Serum creatinine >= 2.0 Serum creatinine =< 1.5 x ULN Serum creatinine < 1.5 x ULN Serum creatinine =< 2.0 x ULN Serum creatinine < 1.5 time the institutional ULN Serum creatinine less than or equal to 2 x ULN Serum creatinine =< 1.5 x ULN Serum creatinine < 2 x ULN Serum creatinine < 1.5 x ULN OR Serum creatinine =< 1.5 x ULN Serum creatinine =< 1.5 X ULN Serum creatinine =< 1.5 x ULN Serum creatinine concentration =< 2 x ULN Serum creatinine concentration <2x ULN Serum creatinine ? 1.5 x ULN Within 8 weeks of randomization: Serum creatinine =< 1.5 x ULN Serum creatinine < 1.5 x of ULN Serum creatinine =< 1.5 x ULN Serum creatinine >1.5x ULN at screening Serum Creatinine < 2.0 times the institutional ULN Serum creatinine < 1.5 x ULN Serum creatinine =< 2 x ULN Serum creatinine =< 1.5 x the ULN Serum creatinine ? 1.5 x ULN Serum creatinine ? 1.5 x ULN Serum creatinine =< 1.5 x the ULN Serum creatinine =< 2.0 X ULN Serum creatinine 1.5 x ULN, but calculated clearances of > 60 Serum creatinine =< 1.5 x ULN or creatinine (Cr) > 1.5 x ULN, but calculated clearances of > 60 Serum creatinine < 2.0 x ULN Serum creatinine =< 2 times ULN Serum creatinine =< 1.5 x ULN Serum creatinine > 1.5 x ULN. Serum creatinine =< 1.5 x ULN Serum creatinine ? 1.5 x ULN Serum creatinine < 1.5 x ULN Serum creatinine < 2 x ULN Serum creatinine < 1.5 × ULN serum creatinine ?1.5 X ULN Serum creatinine ?1.5 ULN. Serum creatinine =< 1.5 x the ULN Serum creatinine < 2 x ULN Serum creatinine =< 1.5 x ULN Serum creatinine =< 2 x ULN Serum creatinine =< 1.5 x ULN Serum creatinine =< 1.5 times the ULN Serum creatinine < 2 x ULN Serum creatinine =< 1.5 x ULN Serum creatinine =< 1.5 X ULN Serum creatinine =< 1.5 x ULN Serum creatinine < 2.0 x ULN Serum creatinine >= 2.5 x ULN 14 days prior to study enrollment Serum creatinine =< 1.5 x the ULN Serum creatinine > 2.0 Serum creatinine greater than 3.0 Serum creatinine =< 2 Serum creatinine =< 1.5 times institutional ULN Serum creatinine < 2 x ULN Serum creatinine < 1.5 x ULN Serum creatinine =< 1.5 times ULN Serum creatinine =< 1.5 x ULN Serum creatinine =< 1.5 x institutional ULN Serum creatinine =< institutional ULN Serum creatinine =< 1.5 x ULN Serum creatinine ? 1.5 x ULN Serum creatinine < 2.0 Serum creatinine (serum or plasma) ? 1.5 x ULN or GFR>50 mL/min Elevated serum creatinine of > 2 Serum creatinine =< 1.5 x ULN Serum creatinine =< within 1.5 x ULN Serum creatinine < 1.5 x ULN Serum creatinine < 1.5 x ULN Creatinine level greater than 1.5 times the upper limit of normal Creatinine =< 1.5 x institutional upper limit of normal within 4 weeks before randomization Creatinine < 1.5 times institutional upper limit of normal, within 21 days prior to study entry Serum creatinine < 1.5 times upper limit of normal OR Creatinine within less than the institutional upper limit of normal Serum creatinine less than 3 times upper limit of normal Creatinine =< 1.5 times the normal upper institutional limit OR creatinine clearance >= 60 mL/min/1.73 m^2 in participants with creatinine levels > 1.5 times the normal upper institutional limit Serum creatinine =< 1.5 times upper limit of institutional normal for age, or and documented within 14 days prior to registration and within 14 days prior to the start of treatment Serum creatinine value of < 1.5 times the upper limit of normal (ULN) Creatinine < 2.0 times upper limit of normal Serum creatinine < 1.5 times upper limit of normal; OR Serum creatinine =< 2 x the institutional upper limit of normal. Serum creatinine < 1.5 times institutional upper limit of normal Creatinine =< 1.5 x institutional upper limit of normal Serum creatinine =< upper limit of institutional normal Creatinine =< 1.5 x institutional upper limit of normal Serum creatinine > 2 times the upper limit of normal Creatinine =< 1.5 X institutional upper limit of normal Creatinine < 1.5 X institutional upper limit of normal Creatinine =< 1.5 x institutional upper limit of normal Serum creatinine =< 1.5 x institutional upper limit of normal Creatinine =< 1.5 x institutional upper limit of normal Creatinine ? 2 times upper limit of normal Serum creatinine of =< 1.5 times upper limit of normal Serum creatinine value of =< 1.5 times the upper limit of normal (ULN) Creatinine =< 1.5 x institutional upper limit of normal Serum creatinine less than or equal to 1.5 x institutional upper limit of normal for age Creatinine =< 1.5 x institutional upper limit of normal EXCLUSION CRITERIA FOR ENROLLMENT: Creatinine >= 2.5 times the upper limit of normal (ULN) Serum creatinine < 1.5 times the upper limit of normal Serum creatinine > 1.5 times the upper limit of normal Serum creatinine =< 1.5 x the institutional upper limit of normal Serum creatinine =< 1.5 times the upper limit of normal (ULN) (normal: =< 1.17 mL/min/1.73 m^2) Serum creatinine =< 1.2 times the upper limit of normal Serum creatinine less than 3 times the upper limit of normal Creatinine =< 2 times upper limit of normal Serum creatinine < 1.5 times upper limit of normal Serum creatinine < 1.5 times upper limit of normal Creatinine =< institutional upper limit of normal Creatinine =< institutional upper limit of normal OR Serum creatinine =< 1.5 times upper limit of institutional for age or Serum creatinine 1.5 times or less than upper limit of normal Creatinine: < 1.5 x institutional upper limit of normal Creatinine =< 1.5 X institutional upper limit of normal Creatinine =< 4 X institutional upper limit of normal Creatinine =< 1.5 x institutional upper limit of normal Serum creatinine =< 1.5 x upper limit of institutional normal Creatinine =< institutional upper limit of normal OR Serum creatinine =< 1.5 x institutional upper limit of normal Creatinine =< 1.5 mg/dL x the institutional upper limit of normal Renal disease: serum creatinine > 2 times upper limit of normal Secondary Registration: serum creatinine =< 1.5 x institutional upper limit of normal Serum creatinine =< 1.5 x institutional upper limit of normal Serum creatinine < 1.5 times the upper limit of normal Serum creatinine < 1.5 x the institutional upper limit of normal Creatinine =< 2 X institutional upper limit of normal Creatinine =< 2.5 x institutional upper limit of normal Creatinine =< 1.5 X institutional upper limit of normal OR Serum creatinine =< the institutional upper limit of normal Creatinine < 1.5 x institutional upper limit of normal OR Serum creatinine =< 1.5 times the institutional upper limit of normal Serum creatinine less than 3 times upper limit of normal Creatinine =< 2 times upper limit of normal Serum creatinine less than 3 times upper limit of normal Creatinine =< 1.5 times the upper limit of normal (ULN) Within 56 days prior to randomization: Serum creatinine =< 1.5 times upper limit of normal (ULN) Serum creatinine should be within normal limits as specified by institutional guidelines; for patients with serum creatinine > upper limit of normal, a 24-hour creatinine clearance will be performed and should be equal to or more than the lower limit of normal Serum creatinine =< 1.5 times the upper limit of normal Creatinine =< 1.5 x the institutional normal upper limit Creatinine =< 2.0 x institutional upper limit of normal Serum creatinine < 1.5 X institutional upper limit of normal Creatinine =< 2 x institutional upper limit of normal if patient has chronic renal insufficiency and creatinine has been stable x > 4 months Serum creatinine 1.5 times or less than upper limit of normal Creatinine within 1.5 times of the institution's upper limit of normal (ULN) Serum creatinine < 1.5 times upper limit of normal; OR Serum creatinine > 3 times the upper limit of normal Creatinine =< 2 x institutional upper limit of normal Creatinine < 2.0 times upper normal limit Creatinine =< 1.5 times the upper limit of normal Serum creatinine =< 1.5 times the upper limit of normal (ULN) Serum creatinine =< 1.5 x the institutional upper limit of normal obtained within 14 days prior to start of therapy Serum creatinine =< 1.5 X institutional upper limit of normal Creatinine =< 2.0 times the institutional upper limit of normal Creatinine =< 1.5 x institutional upper limit of normal OR Creatinine > 2.0 times upper normal limit Creatinine > 1.5 times the institutional upper limit of normal Creatinine =< 2 X institutional upper limit of normal Serum creatinine =< 2 times upper limit of normal Creatinine =< 2 X institutional upper limit of normal Creatinine =< 1.5 times upper limit of normal (ULN) Creatinine < 1.5 times upper limit of normal (ULN) Creatinine =< 1.5 times upper limit of normal (ULN) Patients must have normal organ and marrow function as defined below: leukocytes >3,000/mcL; absolute neutrophil count >1,500/mcL; platelets >100,000/mcL; total bilirubin <1.5 X institutional upper limits of normal; AST(SGOT)/ALT(SGPT) <2.5 X institutional upper limit of normal; Alkaline phosphatase (AP) <2.5 X institutional upper limit of normal; creatinine <1.5X institutional upper limit of normal OR creatinine clearance >50 mL/min/1.73 m2 for patients with creatinine levels above institutional normal Creatinine < 1.5 institutional upper limit of normal OR Serum creatinine < 1.5 times upper limit of laboratory normal Creatinine < 2 times upper limit of normal Serum creatinine of at least 1.5 times the upper limit of normal Serum creatinine =< 2 times the upper limit of normal Creatinine < 2.5 times the upper limit of normal Serum creatinine =< 1.5 times the institutional upper limit of normal (ULN) Creatinine =< 1.5 x institutional upper limit of normal Serum creatinine =< 1.5 the institutional upper limit of normal Creatinine =< 1.5 X institutional upper limit of normal Creatinine =< 2.0 x upper limit of institutional normal for age Serum creatinine =< 1.5 X institutional upper limit of normal Creatinine =< 3 x institutional upper limit of normal Creatinine =< 1.5 x institutional upper limit Serum creatinine < 2 x institutional upper limit of normal OR Creatinine ? 3 times the upper limit of normal (ULN) Grade 2 renal dysfunction: creatinine > 2-3 times the upper limit of normal Creatinine < 1.5 times the upper limit of normal, or: Baseline creatinine (Cr) no greater than 1.5 times the upper limit of normal Serum creatinine =< 2 times the upper limit of normal Serum creatinine must be < 1.5 times the upper limit of the institutional normal range; test results must be no more than 3 months old Serum creatinine < 1.5 times the upper limit of normal Serum creatinine within 1.5 x upper limit of institutional normal Creatinine =< 1.5 x institutional upper limit of normal Creatinine =< institutional upper limit of normal OR Creatinine =< twice upper limit institutional normal Creatinine =< 2.0 times the upper limit of normal SUB-STUDY III: Serum creatinine > 3 times the upper limit of normal Serum creatinine > 2 times the upper limit of normal Serum creatinine > 2 times the upper limit of normal Creatinine =< 1.5 x the institutional upper limit of normal Serum creatinine > 1.5 times upper limit of normal Serum creatinine > 3 times the upper limit of normal Serum ferritin < 2.0 X institutional upper limit of normal Serum ferritin < 2.0 X institutional upper limit of normal Creatinine >= 1.5 times upper limit of normal Creatinine >= 1.5 times upper limit of normal Serum creatinine > 2 times the upper limit of normal Significant history or current renal insufficiency (serum creatinine > 1.5 institutional upper limit of normal) Creatinine =< 1.5 times the institution upper limit of normal (ULN) Creatinine > 1.5 times the institution upper limit of normal (ULN) PARTICIPANTS NOT ON THE HODGKIN LYMPHOMA EXPANSION COHORT: Serum lipase and amylase < 1.5 x ULN, within 2 weeks prior to enrollment PARTICIPANTS ON THE HODGKIN LYMPHOMA EXPANSION COHORT: Serum lipase and amylase < 1.5 x ULN, within 2 weeks prior to enrollment Serum lipase and amylase =< 1.5 x ULN Amylase and lipase =< 2 x ULN Amylase and lipase < 1.5 x ULN obtained ? 14 days prior to randomization Amylase and lipase =< 1.5 ULN; subjects with amylase or lipase > 1.5 ULN may enroll if there are neither clinical nor radiographic signs of pancreatitis Serum lipase and amylase =< 1.5 x ULN. Serum lipase and amylase =< 1.5 x ULN. Serum amylase/lipase =< 1.5 x ULN FULL STUDY INCLUSION CRITERIA: Amylase and lipase =< 1.5 x ULN Serum amylase and lipase =< 2 x ULN Serum amylase and lipase =< 1.5 x ULN Serum amylase and lipase =< 1.5 x institutional ULN Normal serum lipase and amylase (per institutional normal values) Have normal pancreatic status as defined by the following criterion: a. Serum lipase and amylase ? 1.5 × ULN Serum lipase and amylase =< 1.5 x ULN Serum lipase and amylase =< 1.5 x ULN Within 14 days prior to first dose of study drug treatment: Amylase and lipase =< 1.5 x ULN Serum amylase and lipase within normal limits Amylase and/or lipase =< 1.5 x ULN, obtained =< 7 days prior to registration Patients must have a lipase and amylase performed within 7 days prior to sub-study registration Serum amylase and lipase =< 1.5 x the ULN Within 14 days of subject registration: Serum amylase =< 2 x ULN and serum lipase within normal limits Amylase or lipase within normal limit (per institutional standards) Amylase (0-160 U/L) and lipase (0-130 U/L) levels within 1.5 times the range of normal Amylase and lipase =< 1.5 x the upper limit of normal Patients must have a lipase, amylase, TSH with reflex free T3/T4 performed within 7 days prior to sub-study registration; (Note: For the Canadian sites, testing for lipase only is acceptable) Amylase and lipase <=ULN [Applies to Phase 2]. Amylase and lipase ? 2X upper limit of normal Asymptomatic serum amylase or lipase > Grade 2 Adequate pancreatic function, defined as amylase and lipase less than or equal to 1.5 X ULN Amylase and lipase =< 2 times institutional ULN for age Obtained =< 7 days prior to registration:\r\nSerum amylase and lipase =< 1.5 x upper limit of normal (ULN) Serum lipase and amylase =< 2.5 x ULN; NOTE: if subject has tumor involvement in the liver =< 3 x ULN Serum lipase/amylase ?1.5 x ULN Serum amylase > 1.5 x ULN or serum lipase > 1.5 x ULN. Amylase and lipase equal to, or less than, the institutional ULN Amylase and lipase levels =< ULN Amylase and lipase =< 1.5 x ULN Amylase and lipase < 1.5 x of ULN Serum amylase or lipase <1.5 x ULN; Amylase and lipase =< 2 x ULN Amylase and lipase ? 2.5 x ULN (? 5 x ULN for subjects with pancreas involvement with tumor) Serum lipase ? 3 x ULN and serum amylase within the normal range Serum lipase ? 3 x ULN and serum amylase within the normal range Lipase and amylase =< 1.5 x ULN Serum amylase and lipase within normal limits Amylase and lipase ? 1.5 x ULN Amylase and Lipase < 1.5 x normal for age. Sodium or potassium outside normal reference range for site Serum potassium within normal range. Serum potassium within normal range. Potassium (K) should be within the range of >= 3.6 mEq/L Potassium within normal range (supplementation is allowed) Within 28 days prior to treatment start: Potassium within institutional normal range Patients with uncorrectable electrolyte abnormalities with potassium (K) > ULN (upper limit of normal) Serum sodium and potassium within the institutional limits of normal, within 14 days of registration and within 7 days of the start of treatment Potassium within normal limits (WNL) Potassium within institutional normal limits Potassium within institutional normal limit (WNL) Potassium within normal limits prior to the first dose of study medication Potassium within normal limits for the institution Potassium > 3 and < 5.5 mEq/L Potassium between range of 3.0 to 5.5 Potassium in normal range\r\n* Patients with hypokalemia at screening must be corrected prior to initiating treatment Serum potassium >= 3.5 mEq/L Patients with sodium, potassium, or creatinine serum electrolytes > grade 2. Potassium within normal limits for the institution Potassium 3.5-5.0 mEq/L Potassium within normal limits (oral supplementation is allowed) Baseline serum potassium < 3.5 mmol/L (potassium supplementation may be given to restore the serum potassium above this level prior to study entry) Serum potassium within normal limits Subjects must have potassium (K+) >3.5 mEq/l. Serum potassium >= 3.5 mEq/L\r\n* Hypokalemia can be managed and corrected at the physician’s discretion; patients who have hypokalemia must have a repeat serum potassium level drawn within 7 days before starting study drug; patients with a supported potassium level at >= 3.5 can be considered eligible at the physician’s discretion Serum potassium levels outside the laboratory’s reference range Serum potassium within institutional limits of normal (may be corrected with potassium repletion) Potassium within normal limits for the institution Serum or plasma potassium >= 3.5 mmol/L or institutional lower limit of normal (LLN) (independent of potassium supplementation) Serum potassium >= 3.5 mEq/L Potassium within normal limits for the institution Obtained =< 7 days prior to registration: Potassium WNL Potassium within normal limits Serum potassium >= 3.5 mEq/L Potassium Potassium =< 3.5 mEq/L Potassium levels =< grade 1 Use of potassium wasting diuretics during study treatment Serum potassium within normal limits (WNL) Potassium (K) levels: preferred normal limits with no clinical abnormalities Potassium levels within normal limits Potassium within normal limits for the institution Potassium >= 3.0 mg/dl and =< upper limit of normal Serum potassium > 3.3; electrolyte repletion is allowed to reach these values Adequate potassium level > 3.5 mEq/dL Because of the potential risk of corrected QT (QTc) changes, serum potassium levels must be within institutional normal limits Potassium within normal limits for the institution Serum potassium of >= 3.5 mEq/L Serum potassium must be within institutional normal limits Potassium within the normal range of 3.5-5.3 mEq/L Potassium with institutional limits (supplementation allowed) Potassium >= 3.5 mg/dL Potassium within institutional range, obtained within 14 days prior to treatment start Potassium within normal limits Sodium, potassium, chloride, bicarbonate: all =< upper limit of institutional normal Potassium (K) within 2 x ULN Hypersensitivity to potassium iodide or Lugols products Creatinine no greater than the institutional upper limits of normal Creatinine within 1.5 x the ULN institutional limits Creatinine within normal institutional limits Creatinine ? 1.5 x upper limits of normal Creatinine within normal laboratory limits Creatinine =< upper normal institutional limits PIK3CA WILD TYPE COHORT (closed 03/17/2016): Creatinine =< upper normal institutional limits ENDOCRINE RESISTANT COHORT: Creatinine =< upper normal institutional limits Free T4 within institutional normal limits. Creatinine within normal institutional limits Serum creatinine within normal institutional limits OR Creatinine within normal institutional limits Creatinine within institutional normal limits Serum creatinine ? 1.5 X age-adjusted upper limits of normal (ULN) Creatinine within normal institutional limits Creatinine within normal institutional limits OR Creatinine within 1.5 x normal institutional limits. Creatinine within 1.5 x upper limit of normal institutional limits Creatinine within 1.5 x normal institutional limits Serum creatinine within the institutional normal limits, OR if the creatinine is elevated Creatinine within normal institutional limits OR Serum creatinine < 1.5 x upper limits of normal (ULN) Serum creatinine =< 1.5 x normal institutional limits Creatinine within normal institutional limits, assessed within 14 days prior to registration OR PHASE II: Serum creatinine within normal institutional limits Creatinine within normal institutional limits Glucose within normal institutional limits Creatinine < 1.5 x institutional upper limits of normal (ULN) Creatinine within normal institutional limits OR according to Johns Hopkins MRI policy Creatinine =< 1.5 X upper limits of normal Creatinine within normal institutional limits OR Creatinine within normal institutional limits OR Creatinine within or below normal institutional limits Creatinine =< 1.5 X upper limits of normal (ULN) Creatinine < 2 times the upper limits of normal (ULN) Creatinine within normal institutional limits OR Serum creatinine < 2.0 x the upper limits of institutional normal (ULN) Serum creatinine less than 1.5 times the upper limits of normal within 7 days prior to starting treatment Creatinine within normal limits Creatinine within normal institutional limits Urinalysis within normal institutional limits Serum creatinine < 2.0 x the upper limits of institutional normal (ULN) Cardiac function within institutional normal limits on echocardiogram Creatinine within normal institutional limits OR Creatinine =< 1.5 x upper limits of normal Creatinine within normal institutional limits OR Creatinine within normal institutional limits OR Creatinine =< 2 x institutional upper limits of normal Regimens I and II: Creatinine =< 1.5 x institutional upper limit normal (ULN), CTCAE grade 1\r\n* Regimen III: Creatinine no greater than the institutional upper limits of normal Creatinine =< 1.5 x upper limits of normal (ULN) Creatinine =< normal institutional limits OR Creatinine =< 2 times the upper limits of normal (ULN) Serum creatinine within 3 times the upper limits of normal Renal insufficiency: anything over institutional normal limits for creatinine that is also clinically documented Within 14 days of registration: Creatinine within normal institutional limits OR Creatinine < 2 x institutional limits Creatinine within 1.5 x the upper limit of normal (ULN) institutional limits Creatinine =< 2 x upper limits of normal (ULN) Creatinine =< 2 times the upper limits of normal (ULN) Obtained within 2 weeks from study entry: Creatinine =< 1.5 X upper limits of normal Free thyroxine (T4) within normal limits Creatinine within normal institutional limits OR creatinine within normal institutional limits OR Creatinine < 1.5 x institutional upper limits of normal Creatinine =< 2 x normal institutional limits Troponin T or I within normal institutional limits Serum creatinine within normal limits within 90 days prior to registration creatinine within normal institutional limits OR Serum creatinine =< 1.5 X upper limits of normal or creatinine clearance > 60 mg/min for subjects with creatinine levels >= 1.5 X upper limits of normal Cardiac function within institutional normal limits on echocardiogram Serum creatinine within normal institutional limits Troponin I or T within normal limits Serum creatinine less than 1.5 times the upper limits of normal Serum creatinine (Cr) within normal limits (WNL) or Electrolytes within normal limits Coagulation: INR within normal limits, PTT within normal limits Serum creatinine within normal limits Creatinine up to 1.5 X normal institutional limits Creatinine within normal institutional limits OR Hemoglobin within institutional normal limits Platelet count within institutional normal limits Creatinine within normal institutional limits for age Creatinine =< 1.5 x upper limits of normal Creatinine within normal limits Creatinine =< institutional upper limits of normal (ULN) Creatinine =< the upper institutional limits Creatinine within normal institutional limits Serum creatinine < 1.5 x upper limits of normal, or Serum creatinine =< 2.0 x upper limits of normal, or Creatinine within normal institutional limits Normal renal function (defined as creatinine within normal institutional limits) Known chronic kidney disease with creatinine greater than normal institutional limits Within 30 days of eligibility confirmation: Creatinine not above the upper limit of normal institutional limits Renal insufficiency (i.e., serum creatinine outside of normal limits) Platelets within normal institutional limits Creatinine =< the upper institutional limits Creatinine within institutional normal limits Creatinine clearance within normal limits Creatinine within normal institutional limits Creatinine within normal institutional limits serum creatinine w/in normal limits or Total bilirubin within normal limits (must be obtained =< 2 weeks prior to randomization) Total bilirubin < 1.5 x upper limits of normal (ULN) Within 14 days of registration: Bilirubin =< 1.5 x upper limits of normal (ULN) Total bilirubin < 1.5 x upper limits of normal (ULN) RE-REGISTRATION ELIGIBILITY CRITERIA (STEP 2): Total bilirubin < 1.5 x upper limits of normal (ULN) Bilirubin =< 2.0 x upper limits of normal (ULN) Total bilirubin =< 1.5 x upper limits of normal (ULN) (=< 28 days prior to registration) Bilirubin ? 1.5 x upper limits of normal PIK3CA WILD TYPE COHORT (closed 03/17/2016): Total bilirubin =< upper normal institutional limits ENDOCRINE RESISTANT AND ADJUVANT COHORT: Total bilirubin =< upper normal institutional limits Bilirubin should be within normal limits (CTCAE v4.0, grade 1) Total bilirubin =< 1.5 x upper limits of normal (ULN) Total bilirubin =< 1.5 x the upper limits of normal (ULN) Total bilirubin =< 1.5 x the upper limits of normal (ULN) Bilirubin < 1.5 x upper limits of normal (ULN) Total bilirubin =< 1.5 mg/dL X institutional upper limits of normal (ULN) Total bilirubin < 2.5 times the upper limits of normal (ULN) Hepatic dysfunction defined as a bilirubin >1.5 times the upper normal limits, LDH, SGOT and SGPT>2 times upper limits of normal or albumin <3.5 g/dL. Total bilirubin =< 1.5 x the upper limits of normal (ULN) Total bilirubin =< 1.5 x the upper limits of normal (ULN) except for patients with Gilbert’s disease Bilirubin =< 1.5 times upper limits of normal (ULN) For pts with liver metastasis: total bilirubin outside of normal limits Total bilirubin outside of normal limits Total bilirubin =< 1.5 X upper limits of normal Total bilirubin with normal institutional limits; NOTE: for this study, subjects with bilirubin levels > 1.5 upper limit of normal (ULN) are excluded from this enrollment in this study Total bilirubin =< 1.5 x the upper limits of normal (ULN) Normal serum total bilirubin (lower and upper limits of local Laboratory) Bilirubin within normal limits unless patients has Gilbert’s disease and then bilirubin =< 3 x upper limits of normal (ULN) Serum total bilirubin > 2.0 and/or serum transaminases > 3 X the upper limits of normal Total bilirubin < 2.0 x the upper limit of normal and direct bilirubin within normal limits Serum SGOT/AST <3.0 x upper limits of normal (ULN) Serum SGPT/ALT <3.0 x upper limits of normal (ULN) Serum total bilirubin =< 2X the upper limits of normal (ULN). TSH within normal limits at baseline, (if not WLN, then total T3 or free T3 and free T4 should be within normal limits) or stable with treatment. Total bilirubin =< 1.5 x the upper limits of normal (ULN) Total bilirubin: within normal limits at each study site local laboratory Performed within 14 days prior to study: Bilirubin < 3 times the upper limits of the institutional normal Bilirubin =< 1.5 x upper limits of normal Total bilirubin < 1.5 x upper limits of normal Total bilirubin =< 1.5 x upper limits of normal (ULN) Aspartate aminotransferase (AST) =< 2.5 x upper limits of normal (ULN); for patients with liver metastasis: =< 5 x upper limits of normal (ULN) Total bilirubin ? 1.5 x Upper Limits of Normal (ULN) Total bilirubin =< 1.5 x the upper limits of normal (ULN) Total bilirubin ? 1.5 x the upper limits of normal (ULN) Bilirubin, AST and ALT not more than 2 x Upper Limits of Normal Total bilirubin within 3 times the upper limits of normal Total serum bilirubin within normal limits regardless of liver metastases Total bilirubin outside of normal limits; for pts with liver metastasis: total bilirubin outside of normal limits Total bilirubin =< 1.5 x the upper limits of normal (ULN) Total bilirubin =< 1.5 x the upper limits of normal (ULN) Total bilirubin =< 1.5 x the upper limits of normal (ULN) Total bilirubin =< 2.0 x the upper limits of normal (ULN) Total bilirubin =< 1.5 x the upper limits of normal (ULN) Total bilirubin =< 1.5 x upper limits of normal (ULN) Patients must have the following laboratory values: ANC greater than 1500/mcL, platelet count greater than 100,000/mcL, hemoglobin greater than 10 g/dL, bilirubin less than 1.5 x upper limits of normal, AST less than 1.5 x upper limits of normal REGISTRATION INCLUSION CRITERIA: Total bilirubin within institutional upper limits of normal unless related to primary disease Serum bilirubin > 1.5 x upper limits of normal (ULN) total bilirubin <1.5X upper limits of normal Total bilirubin =< 2 X institutional upper limits of normal (ULN) Part A: Serum alpha fetoprotein greater than or equal to 1.5 Upper Limits of Normal, Part B: Serum alpha fetoprotein less than 1.5 Upper Limits of Normal. Not applicable for Part C or D Serum SGOT/AST <3.0 x upper limits of normal (ULN) Serum SGPT/ALT <3.0 x upper limits of normal (ULN) Subject with liver failure as defined by a serum total bilirubin > 2.0 and/or serum transaminases > 3 x the upper limits of normal Bilirubin =< 1.5 x normal limits Bilirubin within normal limits within 90 days prior to registration total bilirubin within normal institutional limits (or <2X the upper limit of normal in those with Gilbert's disease) Total bilirubin outside of normal limits; for patients (pts) with liver metastasis: total bilirubin outside of normal limits Total bilirubin =< 1.5 x the upper limits of normal (ULN) Total bilirubin =< 1.5 x the upper limits of normal (ULN) TREATMENT: Total bilirubin < 1.5 x upper limits of normal Serum total bilirubin is less than or equal to the upper limits of normal Total Bilirubin ? 1.5 x upper limits of normal AST (SGOT) ? 2.5 x upper limits of normal Total bilirubin =< 1.5 x the upper limits of normal (ULN) Total bilirubin < 1.5 x upper limits of normal Total bilirubin =< 1.5 x upper limits of normal (ULN) Total bilirubin =< 1.5 x the upper limits of normal (ULN) Bilirubin =< 1.5 x upper limits of normal Total bilirubin =< 1.5 x the upper limits of normal (ULN) Total bilirubin < 1.5 x upper limits of normal Total bilirubin < 2.0 x upper limits of normal Bilirubin > 2.0 x ULN (institutional upper limits of normal) Bilirubin > 1.5 x ULN (institutional upper limits of normal) Bilirubin =< 2.5 x upper limits of normal if no liver metastases present; serum total bilirubin must be =< 3 x upper limits of normal for patients with Gilbert disease; total bilirubin =< 5 x upper limits of normal if liver metastases present Bilirubin > 1.5 x institutional upper limits of normal (ULN) Total bilirubin =< 1.5x upper limit of normal (ULN) (or if =< 4 gm/dL and direct bilirubin is within normal limits [WNL]) Bilirubin within normal limits Subjects must have adequate renal function defined as a serum creatinine based on age/gender Renal insufficiency with serum creatinine > 1.6 Adequate renal function as evidenced by a serum creatinine =< 1.5 x upper limit of normal (ULN) Adequate renal function as evidenced by a serum/plasma creatinine < 1.5 x ULN Renal: Serum creatinine ? 1.5 times ULN. Renal: creatinine ? 2x of ULN for age Have adequate renal function (Serum creatinine <3 mg/dL). Abnormal renal function (serum creatinine > 2 x ULN) Acceptable renal function: *Serum creatinine ? 1.5 times the ULN. Adequate renal function with serum creatinine ?2.5 mg/dL Patients with impaired renal function as evidenced by creatinine-clearance < 50% for age, weight, height or serum creatinine > 2 x upper normal limit or dialysis-dependent Renal function: serum creatinine ? 1.5 times the ULN range of each institution. Adequate renal function including creatinine < 2 unless related to the disease Adequate renal function: serum creatinine less than 1.5 x upper limit of normal (ULN) Renal function: Creatinine ? 2.0 × ULN Renal function (creatinine <1.5 × ULN) Renal function (creatinine <1.5 × ULN) Adequate renal function with creatinine (Cr) =< 2.5 mg/dL Adequate renal function assessed by: serum creatinine ? 1.5 × ULN Adequate renal function: creatinine ?1.5 x ULN Preservation of renal function, serum creatinine did NOT increase by more than 2 fold above the normal range Preservation of renal function, serum creatinine did NOT increase by more than 2 fold above the normal reference range Renal function: preservation of renal function, serum creatinine did NOT increase by more than 2 fold above the normal reference range Renal function criteria: preservation of renal function, serum creatinine did NOT increase by more than 2 fold above the normal reference range Subjects must have adequate renal function defined as: Serum creatinine based on age/gender. Patients must have adequate Hematologic function(ANC ? 1,500/mcl and platelets ? 100,000/mcl), Renal function(serum creatinine ? ULN or calculated creatinine clearance ? 60 mL/min), Hepatic function(serum bilirubin ? 1.5 x ULN and AST ? 2.5 x ULN and ALT? 2.5 x ULN) Patient must have adequate renal function as defined by serum creatinine < -2.5 mg/dl obtained within 28 days prior to registration Creatinine =< 1.2 mg/dl (urinary diversion is permitted to improve renal function) Adequate renal function defined as serum creatinine equal to or less than 1.5 x upper limit of normal (ULN) Renal function: Serum creatinine >1.5x ULN Renal insufficiency or serum creatinine >1.5 X ULN at screening. Patients must have adequate renal function defined as age-adjusted serum creatinine =< 1.5 x normal for age With impaired renal function as evidenced by creatinine-clearance < 50% for age, weight, height or serum creatinine > 2 x upper limit of normal or dialysis-dependent Adequate renal function: serum creatinine =< 1.5 x ULN Renal Function (creatinine clearance or serum creatinine): Subjects must have adequate renal function as evidenced by a serum creatinine of <2.0 mg/dl. Renal: Creatinine > 1.5x ULN Renal: Creatinine > 1.5x ULN. Renal: Creatinine > 1.5x ULN Adequate renal function: serum creatinine <2.5mg/dL Renal function: • Creatinine less than or equal to 1.5 x ULN Renal: Serum creatinine 1.5 times ULN. Adequate renal function defined as serum creatinine ?3 times the institutional upper limit of normal (ULN) Adequate renal function (defined as serum creatinine =< 1.5 X ULN) Has adequate renal function defined as serum creatinine or ? 1.5 × ULN and creatinine clearance or ? 40 ml/min. Patient has adequate renal function defined as: Serum creatinine ?1.5 the institutional ULN Adequate renal function, defined as serum creatinine ?1.5x ULN Patients with normal renal function according to MD Anderson testing standards and no prior renal disease [screening cut off for serum creatinine < 1.5 times ULN] Renal Status (within 30 days prior to randomization): a) Creatinine no greater than 1.5 times ULN Patients must have adequate renal function (creatinine < 1.5 mg/dL) before starting therapy and the test must be performed within 14 days prior to registration Adequate renal function, defined as serum creatinine ? 2.0 times ULN and creatinine clearance > 50 mL/min Adequate renal function, defined by serum creatinine ? 1.5 x ULN. Patients must have adequate renal function as defined by a serum creatinine =< 1.5 times ULN within one week prior to treatment Has adequate renal function as evidenced by serum creatinine ?2.5 × the upper limit of normal (ULN) for the reference lab; Patients must have an adequate renal function as documented by serum creatinine less than or equal to 2.0 mg/dL. Patient must have adequate renal function documented by a serum creatinine of ? 1.5 times the ULN for the reference lab. Renal function: creatinine ? 1.5 x ULN Adequate renal function, defined as serum creatinine ? 1.5x ULN Adequate renal function as demonstrated by serum creatinine ? 1.5 x ULN, or 24-hr urine creatinine clearance calculation >60 mL/min Creatinine (renal function) =< 1.5 X ULN Abnormal renal function tests (creatinine > 1.5) Renal: Serum creatinine less than or equal to 1.5 times ULN. Renal Function Creatinine >1.5 mg% Hepatic and renal function meeting the strata as outlined below; nota bene (NB): patients must fulfill both total bilirubin and serum glutamic-oxaloacetic transaminase (SGOT)/aspartate aminotransferase (AST) criteria and creatinine function to be included in a group; however, if a patient’s total bilirubin and SGOT/AST and creatinine levels indicate different groups, the patient may be enrolled in the indicated group with the greatest degree of liver dysfunction; all liver and renal function tests must be completed within 24 hours prior to the start of treatment; Note: patients on dialysis will not be eligible\r\n* Group A: hepatic function: normal function (bilirubin =< upper limit of normal [ULN]; AST =< ULN); renal function: normal function (creatinine clearance [CrCl] >= 60 mL/min) \r\n* Group B: hepatic function: normal function (bilirubin =< ULN; AST =< ULN); renal function: moderate dysfunction (CrCl >= 30 and < 60 ml/min)\r\n* Group C: hepatic function: normal function (bilirubin =< ULN; AST =< ULN); renal function: severe dysfunction (CrCl >= 15 and < 30 ml/min)\r\n* Group D: hepatic function: mild dysfunction D1: bilirubin =< ULN; AST > ULN, D2: bilirubin > ULN and =< 1.5 x ULN; any AST; renal function: normal function (creatinine clearance [CrCl] >= 60 mL/min)\r\n* Group E: hepatic function: mooderate dysfunction (bilirubin 1.5 x > ULN and =< 3 x ULN; any AST); renal function: normal function (creatinine clearance [CrCl] >= 60 mL/min)\r\n* Group F: hepatic function: severe dysfunction (bilirubin > 3 x ULN and up to investigator’s discretion; any AST); renal function: normal function (creatinine clearance [CrCl] >= 60 mL/min) Patients must have normal renal function test and no prior renal disease; the screening cut off for serum creatinine is < 1.5 mg/dL Abnormal renal function (serum creatinine level > 2X upper limit of normal [ULN]) as assessed by the central laboratory during screening. Adequate renal function: serum creatinine ? 1.5x ULN; Renal function: serum creatinine ?1.5 times the ULN range of each institution. Subjects must have adequate renal function as defined by serum creatinine < 1.5 x upper limit of normal The participant has adequate renal function as defined by serum creatinine less than or equal to 1.5 x the institutional ULN or creatinine clearance greater than or equal to 60 mL/min for participants with creatinine levels above the ULN. The participant has adequate renal function as defined by serum creatinine less than or equal to 1.5 x the institutional ULN or creatinine clearance greater than or equal to 60 mL/min for participants with creatinine levels above the ULN.