Renal failure requiring hemo-or peritoneal dialysis
Renal failure requiring hemo- or peritoneal dialysis
Renal failure requiring hemo-or peritoneal dialysis
Renal failure requiring hemo-or peritoneal dialysis
Renal failure requiring hemo-or peritoneal dialysis
Renal failure requiring hemo-or peritoneal dialysis
Renal failure requiring hemo- or peritoneal dialysis
Renal failure requiring hemo-or peritoneal dialysis
Renal failure requiring hemo-or peritoneal dialysis
Renal failure requiring hemo-or peritoneal dialysis
Renal failure requiring hemo-or peritoneal dialysis
Renal failure requiring hematological (hemo-) or peritoneal dialysis
Renal failure requiring hemo-or peritoneal dialysis
Renal failure requiring hemo- or peritoneal dialysis
Renal failure requiring hemo- or peritoneal dialysis
Renal failure requiring hemo- or peritoneal dialysis
Renal failure requiring hemo- or peritoneal dialysis
Renal failure requiring hemo- or peritoneal dialysis
Renal failure requiring hemo-or peritoneal dialysis
Renal failure requiring hemo-or peritoneal dialysis
Patients who are on hemodialysis.
Requirement for hemodialysis or peritoneal dialysis
Patients receiving hemodialysis or peritoneal dialysis
Patients who require hemodialysis
Estimated creatinine clearance < 30 mL/min or use of renal replacement therapy (e.g., hemodialysis, continuous renal replacement therapy, peritoneal dialysis) within 7 days prior to Day 1
Receiving renal replacement therapy, hemodialysis, or peritoneal dialysis
Renal failure requiring peritoneal dialysis or hemodialysis
Renal failure requiring hemodialysis or peritoneal dialysis
REGORAFENIB EXCLUSION CRITERIA: Renal failure requiring hemodialysis or peritoneal dialysis
Patients who are on hemodialysis
Patients who are on hemodialysis
Severe renal insufficiency (estimated creatinine clearance <20 mL/min) or on hemodialysis at the time of randomization or likely to require dialysis during the study.
Patients who are on hemodialysis.
Patients who are on hemodialysis
Expected requirement for hemodialysis while on study therapy
Patients requiring hemodialysis
Renal insufficiency requiring hemodialysis or peritoneal dialysis
Patients who are on hemodialysis.
Renal failure requiring hemodialysis or peritoneal dialysis
Requirement for hemodialysis or peritoneal dialysis
Patients on hemodialysis
e. Renal failure needing hemodialysis or peritoneal dialysis
Patients who are on hemodialysis.
Expected requirement for hemodialysis while on study therapy
Serum creatinine level > 1.5 x the upper limit of normal (ULN), chronic renal failure requiring hemodialysis or peritoneal dialysis.
Subjects on hemodialysis or peritoneal dialysis
Serum creatinine will not be used to exclude patients; patients on renal-replacement therapy (e.g., hemodialysis or peritoneal dialysis) will be eligible to participate
Subjects who require routine/intermittent hemodialysis or continuous peritoneal dialysis (due to inability to provide appropriate dosing schedule for oseltamivir) at Baseline. CRRT modalities are allowed.
Renal failure requiring hemodialysis or peritoneal dialysis.
Renal failure requiring hemodialysis or peritoneal dialysis
Receiving renal replacement therapy, hemodialysis, or peritoneal dialysis
Patient is not currently on hemodialysis and/or peritoneal dialysis for management of chronic kidney disease or acute failure/conditions.
Subjects currently receiving hemodialysis
Stage 5 chronic kidney disease or need for hemodialysis
Oliguric acute renal failure (urine output < 500 ml/day) unless already on hemodialysis
Presence of significant renal disease or hemodialysis which would result in dramatic reductions of systemic levocarnitine levels
Patients on hemodialysis
Patients with serum creatinine > 3.0 mg/dL and patients on active dialysis for renal dysfunction are excluded
Dialysis dependent renal failure
Current use of a non-standard dialysis membrane
Patients on dialysis within 7 days of enrollment.
Research participant requires dialysis
Has a history of, or is currently on, dialysis.
Subject is currently on renal dialysis
Patients with renal failure currently requiring dialysis of any kind are not eligible
Currently on dialysis (if receiving contrast for MRI)
Patients on dialysis
Serum creatinine (Cr) > 2 mg/dL, dialysis, or prior renal transplant
Research participant requires dialysis
Serum creatinine > 2.0 mg/dl (unless using non iodinated contrast or on dialysis)
Serum creatinine >= 2.0 mg/dl (unless using non iodinated contrast or on dialysis)
Requiring renal dialysis
Patients on dialysis
Presence of active renal condition (infection, requirement for dialysis or any other condition that could affect subject's safety). Subjects with isolated proteinuria resulting from MM are eligible.
Presence of active renal condition (infection, requirement for dialysis or any other condition that could affect subject's safety). Subjects with isolated proteinuria resulting from MM are eligible, provided they fulfill criteria.
Renal insufficiency requiring dialysis
Patients undergoing renal dialysis.
Patients on dialysis.
Have stable renal function without dialysis for at least 2 months prior to Investigational Product (IP) administration defined by:
current or prior dialysis,
current or prior dialysis,
Renal failure (on dialysis)
Lack of acute renal failure/requirement for dialysis, as evidenced by creatinine < 1.6 mg/dL
Subjects with severe renal impairment requiring dialysis.
History of renal failure requiring dialysis.
History of renal failure requiring dialysis.
Patients on dialysis
Renal dysfunction: Creatinine levels >2 mg/dL or chronic dialysis.
Subjects undergoing renal dialysis
Subjects with severe renal impairment (GFR <50 mL/min/1.73 m²) or on dialysis.
Not currently on renal dialysis or has a history of significant renal impairment
Patients must not be dialysis dependent
Patients on dialysis
Patients on dialysis or with transplanted organs
Diagnosis of kidney disease requiring dialysis
Patients with renal dysfunction (GFR <60) or patients on dialysis
If agreeing to MRI contrast, participant must not be on dialysis
Currently on dialysis
Chronic renal insufficiency requiring dialysis