Patients must be willing to provide prior smoking history as required on the S1400 Onstudy Form
Current use of a smoking cessation medication (e.g. nicotine replacement, varenicline, bupropion)
Noncompliance - inability or unwillingness to comply with medical recommendations regarding therapy or follow-up, including smoking tobacco. Smoking cessation is a standard teaching practice prior to admission for all patients undergoing stem cell transplant. Any patient who refuses to stop smoking prior to transplant will not be eligible for this study.
Co-morbidities that would influence wound healing including diabetes (insulin dependent) or smoking (current ongoing use)
Lifetime pack-year history of < 10 years, currently non-smoking for at least 5 years.
Patients must provide their personal smoking history prior to registration; patients cannot have a cumulative personal smoking history that exceeds 10 pack-years\r\n* Number of pack-years = (frequency of smoking [number of cigarettes per day] x duration of cigarette smoking [years]) / 20\r\n* Note: Twenty cigarettes is considered equivalent to one pack; cigar and pipe tobacco consumption is not included in calculating lifetime pack-years
History of smoking tobacco (or other related/herbal products) in the prior 3 months
Active smoking or a cumulative pack year history of > 20 pack years, active smoking is (defined as >= 1 cigarette per day) within the last 5 years
Currently being treated for smoking cessation, alcoholism, or illicit drug use
Actively smoking 5 or more cigarettes per day for at least one year
Current use of a smoking cessation medication (e.g. nicotine replacement, varenicline, bupropion)
Smoking (cigarettes, cigars or pipes) must be discontinued at least 7 days prior to initiating study drug administration; smoking cessation products (transdermal nicotine patches or chewing gum may be used)
Interested in treatment that might change smoking behavior
Current enrollment or plans to enroll in another smoking cessation program in the next 12 months
Plan to use other nicotine substitutes (i.e., over-the-counter [OTC] or prescription medication for smoking cessation) or smoking cessation treatments in the next 12 months
Interested in quitting smoking in the next 30 days
Involved in current smoking cessation activity
Patients registering to Arms D, E, F, G, H, I, X, Y must not currently be smoking tobacco or other substances and must not have smoked within the past 6 months
RANDOMIZED PHASE II (ARMS K AND L): Patients must not currently be smoking tobacco or other agents
Patients who have a smoking history of > 10 pack-years
Patients who have never smoked, defined as smoking ?100 cigarettes in a lifetime
Smoking (cigarettes, cigars or pipes) must be discontinued at least 7 days prior to initiating study drug administration; smoking cessation products (transdermal nicotine patches or chewing gum may be used.
Intermediate-risk group: Oropharynx cancer that is p16-positive by immunohistochemistry with smoking status > 10 Pack-years, stage T1-2N2b-N3 OR ? 10 pack-years, stage T4N0-N3 or T1-3N3.
History of smoking either tobacco or other herbal products in the last 3 months
Patients must provide their personal smoking history prior to registration; the lifetime cumulative history cannot exceed 10 pack-years; the following formula is used to calculate the pack-years during the periods of smoking in the patient’s life; the cumulative total of the number of pack-years during each period of active smoking is the lifetime cumulative history\r\n* Number of pack-years = (frequency of smoking [number of cigarettes per day] x duration of cigarette smoking [years])/20 \r\n* Note: twenty cigarettes is considered equivalent to one pack; the effect of non-cigarette tobacco products on the survival of patients with p16-positive oropharyngeal cancers is undefined; cigar and pipe tobacco consumption is therefore not included in calculating the lifetime pack-years; marijuana consumption is likewise not considered in this calculation; there is no clear scientific evidence regarding the role of chewing tobacco-containing products in this disease; investigators are discouraged from enrolling patients with a history of very sustained use (such as several years or more) of non-cigarette tobacco products alone
History of >= 10 pack-years of smoking cigarettes
Smoking history < 10 pack-year or equivalent (including cigarettes, cigars, pipes, chewing tobacco, and/or marijuana); one cannabis joint is equivalent of 5 cigarettes; smoking status definitions (National Health Interview Survey and Behavioral Risk Factor Surveillance System):\r\n* Smokers: smoking now every day or some days in past month\r\n* Quitters: at least 100 cigarettes/lifetime and not smoking in the past 1-12 months\r\n* Former smoker: at least 100 cigarettes/lifetime and not smoking > 12 months\r\n* Never smokers: < 100 cigarettes (or equivalent)/lifetime
African American adults who are interested in quitting and whose smoking patterns meet criteria for non-daily smoking as determined by eligibility screening
For NSCLC, patients must have a minimum of a 10 pack-year smoking history.
Patients smoking in excess of 2 packs of cigarettes per day
Having at least a 10-pack year history of cigarette smoking
Patients with oropharynx carcinoma with a smoking history of ? 10 pack-year or equivalent 10 year history of tobacco product use and no recent history (within last 5 years) of tobacco use
Smoking history < 10 pack years or equivalent 10 year history of tobacco product use
Active smoking within the past 20 years with a cumulative pack year history of > 20 pack years or active smoking (defined as >= 1 cigarette per day) within the last 5 years
Patients with > 10 pack years of smoking history and/or currently a smoker at the time of treatment
Patients with smoking history of less than or equal to 10 pack years and with primary tumour site of base of tongue and/or tonsil
Patients with no smoking history
Current use of medications with smoking cessation efficacy
Motivated to stop smoking, as indicated by a score of 6 or above on the Contemplation Ladder
Within the 30 days before registration, no use of: 1) any pharmacologic treatment for smoking cessation, including bupropion or nicotine replacement therapy; 2) any nicotine delivery system (i.e., e-cigarettes and vape products); or 3) be enrolled in any formal behavioral treatment program for tobacco dependence as determined by patient report
Do not smoke (no smoking during previous 12 months)
History of previous experience with smoking or marijuana
Participants must not be active smokers within the past 30 days; active smoking is defined as any smoking, even a puff; if identified as a smoker, the individual will be referred the New York (NY) State Smoking Cessation Quit line (nysmokefree.com) which is available in English and Spanish
Smoking history of 30 pack-years or greater
Participating in a current smoking cessation treatment (counseling or using nicotine replacement therapy [NRT], bupropion, or varenicline)
Note: additional contraindications for individual nicotine replacement therapies and drugs (bupropion, or varenicline) are embedded within each study component to further screen participants when smoking cessation options are being considered
Smoking
Smoking cessation treatment use in past 30 days
Documentation of current smoking in the cancer registry
At least a 30 pack-year smoking history
=< 10 pack-years smoking history or =< 30 pack-years smoking history WITH >= 5 years abstinence from smoking
Patients who have smoked within the last 6 months, since smoking may interfere with relaxation and breathing
Not smoking
Willing to discontinue smoking for the duration of study intervention
Willingness to discontinue smoking during the study two weeks prior to beginning the study and willingness to not smoke while taking study medication
Have at least a 30 pack-year history of smoking
Current tobacco smokers with >= 20 pack years of self-reported smoking exposure and an average use of >= 10 cigarettes/day
Urine cotinine level, if collected at screening, does not confirm active smoking status
Smoking for at least one year
Carbon monoxide (CO) level of 5 ppm or greater, confirming smoking status
Subject considered by the investigator an unsuitable candidate for receipt of a smoking cessation treatment or unstable to be followed up throughout the entire duration of the study
Current tobacco smokers with >= 20 pack years of self-reported smoking exposure and a current average use of >= 10 cigarettes/day
Taking any smoking cessation medications (e.g. varenicline, bupropion, nicotine replacement therapies) at the start of the study
Willing to complete all appointments and change smoking behaviors for 2-weeks
30 pack year history of smoking (i.e., the base population of high risk smokers to get screened)
Reports being a daily or non-daily smoker (any self-reported smoking in the past 30 days) and is interested in treatment that might change smoking behavior.
Following good clinical practice guidelines, be medically suitable for one or more pharmacotherapies for smoking cessation including NRT, bupropion or varenicline, at provider discretion.
Current enrollment or plans to enroll in another smoking cessation program in the next 9 months.
Unwilling to refrain from other nicotine substitutes (i.e., over-the-counter [OTC] or prescription medication for smoking cessation) or smoking cessation treatments in the next 9 months.
Current use of certain medications: (1) Smoking cessation medications (meds) (last 7 days), i.e., Wellbutrin, bupropion, Zyban, NRT, Chantix.
Not currently enrolled in a face-to-face smoking cessation program
Used smoking cessation medications within the past three months
Are currently enrolled in a smoking cessation program
Be interested in quitting smoking
Current use of medications with smoking cessation efficacy
Interested in treatment that might change smoking behavior
Current enrollment or plans to enroll in another smoking cessation program in the next 6 months
Plan to use other nicotine substitutes (i.e., over-the-counter [OTC] or prescription medication for smoking cessation) or smoking cessation treatments in the next 6 months
>= 1 year history of smoking, and smoking >= 5 cigarettes per week
Not currently enrolled in a face-to-face smoking cessation program
Patients must be active smokers (defined as smoking any cigarette, cigar or pipe in the last 30 days)
Patients who chew tobacco and patients who are not smoking but are exposed to second hand smoking are excluded from this study
Patients currently using a smoking cessation medication – any medications prescribed to help with smoking cessation except short acting nicotine replacement therapy (NRT): gum, lozenges, spray, inhalers
Non-smokers (assessed by modified Behavioral Risk Factor Surveillance System [BRFSS] smoking question within screening tool)
Resides in a smoking household (where 1 or more household members smoke)
Interested in quitting smoking
Seeking treatment for smoking cessation
Active smoking (cigarettes per day [CPD] >= 5) and exhaled carbon monoxide (CO) >= 8 parts per million (ppm)
Agree to participate in this randomized smoking cessation trial with follow up assessments up to 12 months
Participants will include current and recently quit former smokers who have at least a 30 pack year smoking history (defined by number of packs smoked per day multiplied by number of years smoked)
Participants must have a smoking history of 20 pack-years or greater
Participation in a smoking study in the past 3 months.
Additionally, prior to enrollment at first session, reporting smoking 28 or more days of the past 30, or registering a carbon monoxide (CO) reading of 15 or above (as this indicates heavy smoking, and is not consistent with non-daily smoking.)
Interested in treatment that might change smoking behavior
Current enrollment or plans to enroll in another smoking cessation program in the next 12 months
Plan to use other nicotine substitutes (i.e., over-the-counter [OTC] or prescription medication for smoking cessation) or smoking cessation treatments in the next 12 months
Not taking medication to help in quitting smoking prior to admission
Current smokers or subjects with any history of smoking
Willingness to abstain from smoking for 8 hours (overnight abstinence) prior to study visits
Used other smoking cessation medications within the past three months
Reside in a facility that does not allow smoking (e.g. certain nursing homes)
SMOKING CESSATION SUB-STUDY: Written informed consent will be obtained by trained study personnel from all participants
For smoking cessation groups, unwillingness to participate or no desire to quit smoking
PHASE I: Individuals at risk for lung cancer based on a smoking history of 20 or more pack/years of cigarette smoking
PHASE II: Smoking history of 20 or more pack/years of cigarette smoking
Already participating in a smoking cessation intervention study
STUDY I: >= 1 year history of weekly smoking
STUDY II: Smoking at least one cigarette per week over the past year
STUDY II: Not currently enrolled in a face-to-face smoking cessation program
Nonsmokers (not smoking during previous 12 months)
All current smokers should accept to receive support for smoking cessation
Current participation in a cancer intervention prevention study, except for smoking cessation
Other types of tobacco, NRT, smoking cessation medications
Self-report regular smoking
Currently using smokeless tobacco, electronic nicotine delivery systems (ENDS), nicotine replacement therapy, or other smoking cessation treatment
Currently smoking 5 or more cigarettes per day
Current use of other smoking cessation medications (e.g., Chantix or Zyban)
Enrolled in another smoking cessation study
Male or female current tobacco smokers with >= 20 pack years of self-reported smoking exposure and an average use of >= 10 cigarettes/day
Urine cotinine level, if collected at screening, does not confirm active smoking status
Interested in quitting smoking
Inclusion Criteria (adult):\n\n          -  Age 18 years or older\n\n          -  Female\n\n          -  Smoked ? 1 cigarettes per day for at least the past 6 months\n\n          -  Smoked on 20 days or more in the last month\n\n          -  Smoking status confirmed via cotinine verification strips\n\n          -  Resides with a child ? 10 years of age in the role of the child's parent or caregiver\n\n          -  Will agree to provide a urine sample at study enrollment\n\n          -  Will also agree to the child providing a urine sample at study enrollment and at\n             follow-up visits (for children who are not toilet trained, a diaper sample will be\n             collected in lieu of the urine sample)\n\n          -  Has a home address\n\n          -  Has a functioning home phone or cell phone\n\n          -  Provides written informed consent\n\n        Inclusion criteria (child):\n\n          -  < or = 10 years of age\n\n          -  Non-smoker -no cigarette use within prior 30 days to enrollment; however\n             experimentation with smoking (a puff) will not exclude the child\n\n          -  Lives in the primary home with the adult study participant at least 5 days a week\n\n        Exclusion criteria (adult):\n\n          -  Current or past 7 day use of Nicotine Replacement Therapy (NRT) or pharmacotherapy for\n             smoking cessation\n\n          -  Planning to move outside of Minnesota within the next 3 months\n\n          -  Have complete home smoking restrictions currently in place verified by the nicotine\n             dosimeter\n\n          -  Currently pregnant
Inclusion criteria:\n\n        Initial from phone interview:\n\n          -  Currently smoking 10-45 cigarettes per day for the past year;\n\n          -  Between the ages of 21 and 70 years;\n\n          -  In apparently good physical health with no unstable medical conditions including\n             seizures or cancer;\n\n          -  In stable and good mental health, i.e., currently do not experience unstable or\n             untreated psychiatric diagnosis, including substance abuse, as determined by the\n             DSM-IV criteria, during the past six months;\n\n          -  Not using any other tobacco or nicotine-containing products;\n\n          -  Not on methadone maintenance or stimulants such as ephedra; not a regular user of\n             street drugs and if uses occasionally, willing to abstain during the study; not taking\n             any drugs known to be P4501A6 substrates such as phenobarbital, rifampicin,\n             dexamethasone, ketoconazole, methoxsalen, pilocarpine, or tranylcypromine due to their\n             role in NNK metabolism;\n\n          -  Does not average more than 21 alcoholic drinks per week;\n\n          -  Willing to perform study activities such as having blood sample drawn, urine\n             collection, multiple clinic visits;\n\n          -  For female subjects of child bearing potential, not known to be pregnant or nursing,\n             or planning to become pregnant within next 12 months.\n\n        For enrollment in the Short-Term Trial:\n\n          -  Subjects who are generally healthy with liver enzyme and blood count values within the\n             ranges shown below based on blood samples drawn at the second screening visit.\n             Specifically:\n\n               -  White blood cells ? 3,000/mL\n\n               -  Total bilirubin ? 1.5 x upper limits of normal (ULN)\n\n               -  AST (SGOT)/ALT (SGPT) ? 2.5 x ULN\n\n               -  BUN and serum creatinine ? 1.5 x ULN\n\n        For enrollment in the Long-Term Trial:\n\n          -  Participated in the short-term trial and invited to participate in the long-term\n             trial;\n\n          -  Possess the GSTM1 null-null genotype;\n\n          -  Smoke 20 or more cigarettes/day with a cumulative smoking history of 20 or more\n             pack-years (one pack-year equals to smoking a pack of cigarettes a day for one year);\n\n          -  Normal liver enzymes based on blood sample drawn during 1 month wash-out;\n\n          -  Determined to be a good candidate for the bronchoscopy procedure by a primary care\n             physician.\n\n        Exclusion Criteria:\n\n          -  Subjects with uncontrolled hypertension, uncontrolled diabetes mellitus, unstable\n             coronary artery disease, history of cancer other than non-melanoma skin cancer, and\n             pregnant or lactating women will not be eligible.
Not interested in quitting smoking in the next 6 months
Participation in a smoking cessation program in the past 30 days
Aim 1 only: 1) smokers who smoke at least 10 cigarettes per day with a stable smoking pattern of at least 6 months and no prior e-cig use within one year; smoking status will be confirmed by salivary cotinine; subjects with at least 10 ng/ml cotinine in their saliva being considered smokers; 2) e-cig users who report using e-cigs daily for 3 months with at least one nicotine-containing cartridge/day or 1 ml of liquid/day; they should have not smoked a cigarette for at least one year; 3) non-smokers who have smoked less than 100 cigarettes in their lifetime and not for at least 1 year, and not have used an e-cig for at least 1 year; lack of regular smoking will be confirmed by salivary cotinine
Subjects with a smoking history of at least 5 cigarettes daily for at least 1 year (carbon monoxide [CO] > 8 parts per million (ppm); if CO =< 8 ppm, then Nic Alert test =< level 3) and no serious quit attempts in the last 3 months (to ensure stability of smoking)
Household members must be current smokers, defined as smoking at least one cigarette most days per week
Willing to consider quitting smoking
Patient smoking status will be documented in their electronic health record, per routine care
Have at least a 30-pack year smoking history (average packs per day x years smoking)
Smoking cigarettes for at least 3 years (so that smoking is expected to be reasonably established)
Smoking, on average, 4-27 days per month (the lower limit avoids including intermittent smokers [ITS] whose smoking is so sparse that it cannot be stably observed or assessed over a 2-week period; the upper limit avoids recruiting people who are essentially daily smokers.)
Smoking non-daily for the previous one year
Willingness and ability to come to the University of Pittsburgh’s Smoking Research Group lab for 11 visits over a 12-week period, and to report on smoking behavior via an IVR telephone system during that time
Current use of medications such as chantix (varenicline), zyban, wellbutrin, or bupropion for any purpose, including stopping smoking
At first session, reporting smoking 28 or more days of the past 30, or registering a carbon monoxide (CO) reading of 15 or above
at least some concern for health effects of smoking
current use of any smoking cessation medications
current enrollment in a smoking cessation treatment study
Daily smoker using 10 or more cigarettes per day
Active smoker
NSCLC cohort only: current smoker
Is a current smoker
Non-smoker
Daily smoker for ?6 months
Self-reported current smoker
Patient is a current or ex-smoker with a smoking history of >= 10 pack years
AIM 2: Must be a current or recent former smoker (defined as smoked within past 6 months)
AIM 2: Former smoker greater than 6 months
Families of all children who have at least one custodial parent smoker
Subject is a current smoker, or has smoked within 3 months prior to enrollment, or plans to resume smoking within 3 months post-enrollment
As per self-report, is a regular smoker (daily use)
Current daily smoker
Smoker
Current smoker of >= 10 cigarettes per day, on average
The subject is a current smoker (has smoked within 4 weeks prior to surgery)
INHALATION: Are a smoker
Current or ex-smoker with at least 10 pack-year history
Currently a smoker, defined as self-reported cigarette smoking (some days, every day) within the past 30 days
Current smoker (i.e., at least 10 cigarettes/day)
Current smoker (defined as any smoking in the past 30 days – this is the criteria our lung cancer screening programs will use to trigger tobacco treatment interventions)
Daily smoker for ? 6 months, smoking approximately ? 5 cigarettes per day on average in the past month or must meet the criteria for nicotine dependence
Be either a current smoker or a never smoker; to define a smoker, we will utilize the Centers for Disease Control definitions; any individual who is currently smoking and has smoked more than 100 cigarettes in their lifetime will be identified as a current smoker; smoking status will be assessed by a questionnaire; smoking status will be conferred using a urine cotinine test at the randomization visit (week-2); the number of cigarettes smoked per day and years of smoking will be used to calculate pack-years, which will be used as a measure of tobacco exposure; a never smoker is defined as a person who has never smoked, or has smoked less than 100 cigarettes in their lifetime, and who has not had a cigarette in over ten years
Smoker or uses smokeless tobacco products
Is a current smoker – self defined
Current smoker
Current smoker
Non-smoker
A current or ex-smoker with a >= 10 pack-year history of smoking; (an ex-smoker is defined as no tobacco use in the prior 6 months)
Current or ex-smoker with at least a 10-year pack history
Current smoker (> 5 cigarettes per day for the past 3 months)
Self identified as a smoker
Must be a former or current smoker
current smoker
Non-smoker
Current or former smoker by self-report
Current smoker of >= 5 cigarettes daily, determined by self-report
Current smoker, or former smoker who has less than a 16-year quit history
Daily smoker;
current smoker of at least 5 cigarettes per day for at least 1 year
daily (25+ days within past 30) cigarette smoker of >5 cigs/day