Subjects with pleural effusions requiring thoracentesis or ascites requiring paracentesis within 14 days prior cycle 1, day 1 Subjects with pleural effusions requiring thoracentesis or ascites requiring paracentesis Subjects with pleural effusions requiring thoracentesis or ascites requiring paracentesis within 21 days prior to registration Clinically significant ascites defined as requiring ? 1 paracentesis every 2- weeks Subjects with pleural effusions requiring thoracentesis or ascites requiring paracentesis within 14 days prior to initiation of ABC294640 Ascites requiring active medical management including paracentesis Subjects with pleural effusions requiring thoracentesis or ascites requiring paracentesis within 14 days prior to enrollment Subjects with pleural effusions requiring thoracentesis or ascites requiring paracentesis within 14 days prior to enrollment Subjects with pleural effusions requiring thoracentesis or ascites requiring paracentesis within 14 days prior to randomization Patients with pleural effusions requiring thoracentesis or ascites requiring paracentesis within 14 days prior to registration are NOT eligible for participation Has ascites that requires frequent paracentesis or a pleural effusion that requires repeated thoracentesis Ascites requiring active medical management, including paracentesis Ascites requiring active medical management including paracentesis. Subjects with pleural effusions requiring thoracentesis or ascites requiring paracentesis within 14 days prior to randomization Subjects with pleural effusion requiring thoracentesis or ascites requiring paracentesis within 14 days prior to admission Patients with ascites requiring paracentesis within 2 weeks prior to study entry (signature of informed consent) and during the screening period. Ascites requiring active medical management including paracentesis. Subjects with pleural effusions and/or ascites, due to malignancy, requiring paracentesis every 2 weeks or more frequently. Pleural effusions requiring thoracentesis, or ascites requiring paracentesis, within 14 days prior to enrollment Pleural effusions requiring thoracentesis within the 14 days prior to randomization Ascites requiring paracentesis within the 14 days prior to randomization Subjects with pleural effusions requiring thoracentesis or ascites requiring paracentesis within 14 days prior to the first day of treatment No subjects with pleural effusions requiring thoracentesis or ascites requiring paracentesis within 14 days prior to cycle 1 day 1 Subjects with pleural effusions requiring thoracentesis or ascites requiring paracentesis Subjects with pleural effusions requiring thoracentesis or ascites requiring paracentesis within 14 days prior to randomization History of recurrent ascites requiring paracentesis within 4 weeks of study day 1. Pleural effusions requiring thoracentesis or ascites requiring paracentesis within 14 days of first dose History of medically significant ascites requiring repetitive paracentesis Subjects with pleural effusions requiring thoracentesis or ascites requiring paracentesis within 14 days prior to first dose. Subjects with pleural effusions requiring thoracentesis or ascites requiring paracentesis within 14 days prior to randomization Patients with pleural effusions requiring thoracentesis or ascites requiring paracentesis within 14 days prior to randomization. Pleural effusions requiring thoracentesis or ascites requiring paracentesis Pleural effusions requiring thoracentesis or ascites requiring paracentesis Subjects with pleural effusions requiring thoracentesis or ascites requiring paracentesis within 14 days prior to randomization Ascites requiring paracentesis for symptom improvement Pleural effusion or ascites that causes respiratory compromise (>= NCI-CTCAE version 4.0 grade 2 dyspnea) Pleural effusion or ascites that causes respiratory compromise, grade 2 dyspnea Pleural effusion or ascites that causes respiratory compromise (>= NCI-CTCAE version 4.0 grade 2 dyspnea) Pleural effusion or ascites that causes respiratory compromise (>= NCI-CTCAE version 4.0 grade 2 dyspnea) Pleural effusion or ascites that causes respiratory compromise (>= NCI-CTCAE version 4.0 grade 2 dyspnea) Pleural effusion or ascites that causes respiratory compromise (>= NCI-CTCAE version 4.0 grade 2 dyspnea) REGORAFENIB EXCLUSION CRITERIA: Pleural effusion or ascites causing respiratory compromise (dyspnea grade 2 or higher) Pleural effusion or ascites that causes respiratory compromise (? NCI-CTCAE version 4.03 Grade 2 dyspnea) Pleural effusion or ascites that causes respiratory compromise (ie, >= grade 2 dyspnea) Pleural effusion or ascites that causes > grade 1 dyspnea Pleural effusion or ascites that causes respiratory compromise (? CTCAE Grade 2 dyspnea). Pleural effusion or ascites that causes respiratory compromise (>= NCI-CTCAE version 4.0 grade 2 dyspnea) Pleural effusion or ascites that causes respiratory compromise (eg, >= grade 2 dyspnea) Active signs and symptoms of interstitial lung disease pleural effusion or ascites that causes respiratory compromise (>= grade 2 dyspnea) Pleural effusion or ascites that causes respiratory compromise (>= NCI-CTCAE version 4.0 grade 2 dyspnea) Pleural effusion or ascites that causes respiratory compromise (? NCI-CTCAE version 4.03 Grade 2 dyspnea). Pleural effusion or ascites that causes respiratory compromise (>= NCI-CTCAE version 4.0 grade 2 dyspnea) Pleural effusion or ascites that causes respiratory compromise (>= CTCAE version 4.0 grade 2 dyspnea) Pleural effusion or ascites that causes respiratory compromise (>= NCI-CTCAE version 4.0 grade 2 dyspnea) Pleural effusion or ascites that causes respiratory compromise (? NCI CTCAE version 4.0 Grade 2 dyspnea). Pleural effusion or ascites that causes respiratory compromise (>= NCI-CTCAE version 4.0 grade 2 dyspnea); patients may undergo thoracentesis and paracentesis to improve symptoms prior to enrollment Pleural effusion or ascites that causes respiratory compromise Pleural effusion or ascites that causes respiratory compromise (>= grade 2 dyspnea) Pleural effusion or ascites that causes respiratory compromise (>= grade 2 dyspnea CTCAE)