DONOR: Karnofsky performance status of 90-100% (adults) or Lansky play performance status of 100% (children) Patient must have a Karnofsky performance status or Lansky* play status >= 50\r\n* For purpose of determining performance scores, wheelchair-bound patients will be considered ambulatory Performance status as determined by Karnofsky >= 60 or Lansky play scale >= 60% at the time of study drug administration Adequate performance status as follows\r\n* Patients >= 16 years must have Eastern Cooperative Oncology Group (ECOG) performance status 0-2 (Karnofsky >= 60%)\r\n* Pediatric patients < 16 years must have Lansky play-performance of 60-100% Karnofsky performance status of >= 60% or, if less than 16 years of age Lansky play score of >= 60 Adequate Karnofsky Performance score or Lansky Play-Performance scale For subjects < 17 years of age, Modified Lansky Play-Performance Score of >= 70%; for subjects 17 and older, Karnofsky score of >= 70% Lansky play-performance score < 40 for pediatric patients Lansky play score >= 50 Karnofsky >= 80%, Lansky play score >= 70 Performance Status: Karnofsky ? 70%, Lansky play score ? 70 With Karnofsky index or Lansky play-performance scale > 70% on pre-transplant evaluation DONOR: Donors in good general health, with a Karnofsky or Lansky play performance score > 90% Karnofsky performance score < 70% or Lansky-Play Performance score < 70 for pediatric patients Adequate Karnofsky Performance score or Lansky Play-Performance scale Performance status as determined by Karnofsky >= 60% or Lansky play scale >= 60% at the time of study drug administration Lansky play score >= 60 (< 16 years) or Karnofsky (16 years or older) performance score of >= 60% Karnofsky score < 50%\r\n* Pediatric criteria\r\n** Lansky play-performance score < 40 Karnofsky score less than 60; pediatric criteria: Lansky Play-Performance Score < 40 Karnofsky performance status > 80% for ages 16 years and older or Lansky play score > 50 for < 16 years Performance score ? 60 from Lansky Play Performance Scale if ?16 years Karnofsky Performance Status >= 50% for patients 16 years and older and Lansky Play Score >= 50 for patients under 16 years of age Karnofsky performance score or Lansky Play-Performance Scale score < 80 Lansky-play performance score < 50 for pediatric patients Have an ECOG PS score of 0 or 1 STEP II: ECOG performance status 0, 1, or 2 (PS 3 allowed if secondary to pain) ECOG performance status (PS) score 0-1. ECOG PS 0-1. Patients must have an ECOG Performance Status (PS) ? 1. ECOG performance status (PS) ? 1. ECOG PS of 0-2 Have an ECOG performance status (PS) of ?2. ECOG performance status (PS) of 0 or 1 a. ECOG PS of 2 may be eligible upon the review and approval of the Medical Monitor. Subjects with PS of 0 or 1 on the ECOG Performance Scale Subject has a performance status (PS) of 0-2 according to the Eastern Cooperative Oncology Group (ECOG) scale. Subjects with ECOG PS of 3 may be included if decreased PS is secondary to DLBCL only, and not to comorbidities. ECOG PS >= 2 Patients must have an ECOG PS of 0-1 at screening. ECOG PS 0, 1, or 2. Performance Status (PS) ? 2: The patient has an ECOG PS of 0-2. PHASE IB: ECOG PS 0-1 Have an ECOG PS of 0 to 1, with the exception of patients in Part 2 (Cohort 3, unfit bladder cancer patients) who may have an ECOG PS of 2 ECOG PS score of 0 to 2 ECOG Performance Status (PS) 0-2; + 0 for (PS=0), +2 for (PS=1), +4 for (PS >1). ECOG PS >2. ECOG Performance Status (PS) 0-1; FULL STUDY INCLUSION CRITERIA: ECOG PS of 0 or 1 ECOG PS of 0 to 2 at screening. ECOG performance status (PS) 0-2 ECOG performance status (PS) of 0 or 1 Has an ECOG PS of 0, 1, or 2 ECOG PS 0-2. Subjects with high PB blasts >50% AND poor ECOG PS of 2. Patients must have an ECOG PS of 0-1 at screening and on the day prior to treatment. ECOG PS 0 or 1 ECOG PS 0-1. ECOG performance status (PS) ? 1 ECOG PS 0-2 Performance status (ECOG PS) 0-2 PS ECOG < 2 Performance status (PS) >70% Karnofsky or ECOG ?2; ECOG performance status (PS) 0 to 2. ECOG Performance Status (PS) 0-1; ECOG performance status (PS) 0-3 (restricted to ECOG PS 0-2 if >= 70 years of age) ARM B: ECOG performance status (PS) 0 or 1 Subjects must have ECOG PS of 0 to 2. ECOG PS 0-1 Patient must have ECOG PS of 0 to 2 ECOG PS 0 - 2 The patient has an ECOG performance score (PS) of 0-2. The patient has an ECOG performance score (PS) of 0-2. ECOG performance status (PS) of 0 or 1 ECOG Performance Status (PS) score of 0-1. PS 0 to 1 PS 2 ECOG-PS 0 or 1 ECOG PS of ?1. ECOG PS of 0 or 1. Patients with an ECOG PS of 2 may be entered upon review and approval of the medical monitor. ECOG PS of 0, 1, or 2 Subjects must have ECOG PS of 0 to 1. Eastern Cooperative Oncology Group performance status (ECOG PS) 0 to 2. In case of ECOG PS 2, the PS has to be due to metastatic prostate cancer to the bone. Zubrod performance status (PS) 0-2 or equivalent Karnofsky PS ECOG Performance Status (PS) 70 years old and cannot tolerate surgery) Zubrod performance status of =< 2 Zubrod Performance Status 0-2 within 4 weeks prior to enrollment Zubrod performance status 0-1 or Karnofsky performance status > 70%; patients > 50 years will have to have a Sorror Comorbidity Index =< 3 Patients must have a performance status of 0-2 (Zubrod scale) Zubrod performance status 0-2 or equivalent Zubrod performance status 3 or greater Zubrod performance status < 2 Zubrod performance status of 0 -1 Have a performance status of 0 to 1 on the Zubrod performance scale The patient’s Zubrod performance status must be 0-2 Zubrod performance status =< 2 Zubrod performance status 0-2 Patients must have a Zubrod performance status of =< 2 Patients must have a Zubrod Performance Status as follows: Zubrod performance status 0 to 2 or Karnofsky of at least 60 Zubrod performance status 0-3 Zubrod performance status 0-2 Zubrod performance status 0-2 The patient’s Zubrod performance status must be 0-2 Zubrod performance status (PS) of =< 2 Karnofsky Performance Status of 70% or greater, or Zubrod Performance Status of 1or less. Zubrod performance status 0-2 ELIGIBILITY FOR TREATMENT: ECOG/Zubrod performance status of 0 to 2 Zubrod performance status >= 3 Patients must have a Zubrod performance status of =< 2 Zubrod performance status less than or equal to 1 Zubrod performance status 0-1 Patients must have Zubrod performance status 0-2 Zubrod performance status 0-2 Zubrod performance status 0-1 Zubrod performance status 0-2 Zubrod performance status 0-2 Patient must have Zubrod performance status 0-2 Patients must have Zubrod performance status of 0 - 2 Patients must have a performance status of 0-2 by Zubrod criteria Patients must have a Zubrod performance status of 0 - 2; Zubrod performance status 3 will be allowed if from bone pain only Patients must have a Zubrod performance status of 0 or 1 Zubrod performance status 0-2 Patients must have Zubrod performance status =< 1 CLINICAL/LABORATORY CRITERIA: Patients must have Zubrod performance status of 0-2 The patient’s Zubrod performance status must be 2 or greater OR patients with Zubrod performance status 0-1 and weight loss > 10% are considered eligible; in addition, patients determined to be medically unfit or refusing combined modality therapy are eligible Patients must have Zubrod performance status 0-1 Patients must have a Zubrod performance status of 0 or 1 Patients must have a Zubrod performance status of 0-1 Zubrod performance status 0 or 1 Zubrod performance status 0-1 Patients must have a Zubrod performance status of 0-1 Patients must have a Zubrod performance status of 0-1 Patient must have Zubrod performance status of 0-2 Zubrod performance status of 0-2 Zubrod Performance status of 0-1 Patients with Zubrod performance status 0-1 Patients must have Zubrod Performance Status of 0-1. Patients must have Zubrod performance status =< 2 The patient’s Zubrod performance status must be Zubrod 0-2 Patients must have a Zubrod performance status (PS) of 0-1 Patients must have a Zubrod performance status of 0-1 Zubrod performance status =< 3 Zubrod performance status =< 1 Zubrod performance status 0-1 Zubrod performance status 0-2 Patients must have a Zubrod performance status of 0-1 Zubrod performance status of 0-1 Zubrod performance status 0-2 within 14 weeks prior to enrollment Zubrod performance status =< 2 or Lansky of >= 60% The patient’s Zubrod performance status must be 0-2 Zubrod performance status =< 2 (Karnofsky >= 60%) Patients must have a performance status of 0-2 by Zubrod criteria Zubrod performance status 0-3 Patients must have Zubrod performance status score of =< 2 Patients must have Zubrod performance status =< 1 Patients must have Zubrod performance status =< 2 Zubrod performance status 0-2 Patients with a Zubrod performance status 3 or 4 Zubrod performance status (PS) 2 or less The patient’s Zubrod performance status must be 0-2 Patients must have adequate performance status (Zubrod 0-2) Zubrod performance status of 0-3 Patients must have a performance status of 0-2 by Zubrod criteria Zubrod performance status 60 % (or a Zubrod performance status of < 2). Zubrod performance status < 2 Patients must have Zubrod performance status =< 3 Zubrod performance status 0-2 Zubrod performance status 0-1 or Lansky performance status (PS) greater or equal to 70% ECOG/Zubrod Performance Status > 2. Zubrod performance status of ‘0-1’ Patients must have a Zubrod Performance status of 0-2 Patients must have Zubrod performance status =< 2 Performance status 0-2 on Zubrod performance scale Zubrod performance status 0-2 Zubrod performance status =< 1 Patients must have Zubrod performance status of 0-2 Patients should have a Zubrod =< 1 Patients should have a Zubrod =< 2 Patients must have a Zubrod performance status of 0 to 1 Patients must have a Zubrod performance status of 0-2 Have a Zubrod performance status of 0 to 2 Patients should have a Zubrod =< 2 Patients with Zubrod performance status >= 3 Patients must have a Zubrod performance status of 0-1 Patients with Zubrod performance status of > 2 Zubrod performance scale 0-1 Zubrod performance status 0, 1, or 2 Zubrod performance status 0, 1, or 2 Zubrod performance status 0-2 Zubrod performance status of 0-2 Patients must have a Performance Status (Zubrod) performance status of 0-1 Zubrod performance status of ‘0-2’ or Karnofsky score > 60% Patients must have Zubrod performance status of 0-2 within 7 days prior to hospitalization Karnofsky Performance Scale of > 40. Karnofsky performance scale ? 60% Karnofsky Performance Status Scale (KPS) score of ? 70. Karnofsky performance scale > 70. Karnofsky performance scale >= 70% Performance status of >= 70% on the Karnofsky scale Karnofsky performance scale >= 70% Karnofsky performance scale (KPS) score >= 70 Karnofsky Performance Scale (KPS) ? 60%. ECOG performance scale of 0-1 Lansky/Karnofsky performance scale > 60% Karnofsky or Lansky performance scale (PS) greater or equal to 70 Performance status of Karnofsky scale 60%-100% or ECOG performance scale 0-2. Karnofsky performance scale > 70. Have a performance status of >= 60 on the Karnofsky performance scale (KPS). Karnofsky Performance Scale score >= 60% Performance status of >= 70% on the Karnofsky scale Karnofsky performance scale (KPS) >= 70% Karnofsky Performance Scale (KPS) score ?60 Karnofsky performance scale > 60% Performance status of 60% or greater by the Karnofsky scale Karnofsky performance scale (KPS) >= 70% Have a performance status of >= 60 on the Karnofsky performance scale (KPS) Patient must have a score on the Karnofsky performance scale of >= 80% Karnofsky Performance Scale (KPS) score greater than or equal to 60. Minimum Karnofsky Scale Patients must have a performance status of >= 70% on the Karnofsky scale Karnofsky performance scale >= 30 (>= 50 for patients ages 60-70 years) Intermediate or high grade lesions: 2 or 3 on a scale of 1-3 or grades 2 to 4 on a scale of 1-4 Karnofsky performance scale (KPS) >= 70% or Karnofsky Performance Scale (KPS) > 60% at time of study enrollment Karnofsky performance scale (KPS) >= 80 Karnofsky performance scale (KPS) >= 70% Lansky or Karnofsky scale >50 Performance status according to the Karnofsky Performance Scale ?70%. 10. Performance status according to the Karnofsky Scale of ? 70% (after palliative measures such as pleural drainage). Karnofsky performance scale ?70% Performance scale (PS) 0-3 Karnofsky performance scale (KPS) score < 80 Performance score minimum requirement is >= 50 on Karnofsky/Lanksy performance scale Karnofsky performance scale (KPS) >= 70 Karnofsky performance scale (KPS) >= 80 Karnofsky performance scale (KPS) score of >= 60 Performance status >= 70 (Karnofsky performance scale) Patients with a performance status of >= 70% on the Karnofsky scale Karnofsky performance scale >= 70% Performance status of 60 or higher (Karnofsky scale) Karnofsky Performance Status Scale of 60 or higher OR an ECOG Performance Status of 0-2. Performance status of 60 or higher on Karnofsky scale Performance Status (PS): ? 70% Karnofsky Performance Scale (KPS) Adequate performance status: children < 10-Lansky score >= 30; children >= 10-Karnofsky >= 30 (except for posterior fossa syndrome) Lansky performance status >= 50 Karnofsky or Lansky performance status ? 60%. Lansky/Karnofsky performance status >= 60% Performance status: Karnofsky/Lansky score > 50%. Performance status >= 50% (Lansky for =<12ys; Karnofsky for >12ys) Karnofsky or Lansky performance status >= 70% AUTOLOGOUS APHERESIS: Karnofsky or Lansky (age-dependent) performance score >= 50 MANUFACTURING SJCAR19: Karnofsky or Lansky (age-dependent) performance score >= 50 TREATMENT WITH SJCAR19: Karnofsky or Lansky (age-dependent) performance score >= 50 Karnofsky or Lansky performance status of >= 70 Karnofsky or Lansky (subjects <16 years) performance status ?60 Have a Karnofsky (adult) or Lansky (for =< 16 years) performance status >= 60% Performance status: Lansky or Karnofsky score ? 60% and minimum life expectancy of at least 4 weeks Karnofsky or Lansky performance status >= 70% Karnofsky or Lansky (age-dependent) performance score >= 50 Lansky/Karnofsky performance status score of 50-100 Lansky or Karnofsky ?50 Performance status defined by Karnofsky or Lansky >= 30 (except for patients with posterior fossa syndrome); other requirements of performance evaluation are the same as above Performance status defined by Karnofsky or Lansky >= 30 (except for patients with posterior fossa syndrome); other requirements of performance evaluation are the same as listed above Karnofsky or Lansky performance status >= 80 Karnofsky/Lansky performance status >= 60% Karnofsky/Lansky performance status >= 60% (Arm B) Zubrod performance status 0-1 or Lansky/Karnofsky performance status (PS) equal or greater to 80% Karnofsky or Lansky performance status of >= 50% Karnofsky or Lansky (age-dependent) performance score >= 50 Good performance status (Karnofsky/Lansky 70-100) Karnofsky/Lansky performance status < 40. Patients must have a Karnofsky (adult) or Lansky (pediatric) performance status >= 70% Karnofsky performance status (KPS) or Lansky score >= 20 Karnofsky performance status (KPS) or Lansky score > 50 Lansky/Karnofsky scores >= 60 Patients must have a Karnofsky (adult) or Lansky (pediatric) performance status >= 70% Karnofsky performance status >= 70% or Lansky >= 50% Karnofsky performance status > 70% or Lansky > 50% Karnofsky performance status (KPS) or Lansky score >= 60 EXCLUSION FOR COLLECTION OF T CELLS/PBMCS: Karnofsky/Lansky performance status < 60 EXCLUSION FOR TREATMENT: Karnofsky/Lansky performance status < 60 Karnofsky or Lansky ? 50 Performance status: Karnofsky or Lansky score ? 60% (Appendix A) Karnofsky/Lansky performance status >= 60% The patient has a Lansky/ Karnofsky performance status score of ? 70% Patients must have a Karnofsky (adult) or Lansky (pediatric) performance status >= 70% Lansky or Karnofsky performance status >= 70% Lansky/Karnofsky performance status score of 40-100 Karnofsky or Lansky performance status >= 60% ECOG performance status (PS) 0-1.Pediatric patients with Lansky or Karnofsky Performance Status Scale ? of 50%. Adequate performance status as defined by Lansky Score >= 30 (except for Posterior Fossa Syndrome) Quality of life must be 3 by Lansky and 50% by Karnofsky Patient has a minimum Karnofsky/Lansky Performance Level of at least 30 at the time of study entry. Karnofsky Performance Status (KPS) or Lansky Score ? 50 Karnofsky or Lansky (age-dependent) performance score >= 50 Performance score of >=50% according to the Karnofsky/Lansky performance status scale. Karnofsky or Lansky (age-dependent) performance score >= 50 Zubrod performance status < 2 or Lansky/Karnofsky performance status (PS) equal or greater to 70% Patients must have a Karnofsky (adult) or Lansky (pediatric) performance status >= 70% Lansky or Karnofsky performance >= 40% Lansky performance status or Karnofsky performance status of >= 50 percent Performance status: Karnofsky/Lansky score > 60%. Karnofsky score of > 60% Patients with a Karnofsky score of >= 50 Karnofsky score > 70 %. Karnofsky performance score >= 70 Karnofsky Performance Score < 70% Participant has Karnofsky performance status score < 70% . Karnofsky Performance Score of ? 70% at the time of entry Karnofsky performance score > 60 Karnofsky performance score (KPS) score >= 70 Karnofsky performance status score of >= 60 % Karnofsky performance score of greater than or equal to 70 Karnofsky performance score >= 70 Karnofsky performance score must be >= 60 Performance score of at least 60% by Karnofsky Karnofsky performance status score of 70% or greater Patients must have Karnofsky performance score >= 70 AT THE TIME OF INFUSION: Karnofsky score ? 60 TREATMENT: Karnofsky score ? 50% Karnofsky performance score >= 60 Karnofsky performance score >= 70% TREATMENT: Patients with a Karnofsky score of ? 50 PART 2: Performance status score\r\n* Karnofsky >= 70 Karnofsky performance status score >= 70 Karnofsky score of >= 70% Karnofsky performance score < 70 Karnofsky score (KS) >= 50 Patient must have a Karnofsky performance score of >= 70 Karnofsky score >= 70 Karnofsky score < 50% for adult patients Karnofsky score > 70 % Karnofsky performance score 70 Karnofsky performance score 70 Poor performance status (Karnofsky score of less than 60) Karnofsky performance score 70% or higher. Karnofsky performance score >= 70 Patients must have a Karnofsky performance score of 50% or greater Karnofsky performance score >= 70% Adequate functional status (Karnofsky Performance Score ?60) Karnofsky performance score < 70% Karnofsky performance score greater than or equal to 70% Adequate performance, i.e.\Karnofsky Performance Score\ of at least 70%; Karnofsky performance score 70% or higher Have a Karnofsky score ? 70 All patients must have a Karnofsky performance score > 60% Karnofsky performance score ?70. Karnofsky performance status score ?70%. Karnofsky performance score of 70 or higher Patients must have Karnofsky performance score >= 60 Karnofsky performance status score ? 50%. The patient must have a Karnofsky performance score of 40 or greater Karnofsky performance score >= 60% Karnofsky Performance Score ?70% Subjects must have a performance score of Karnofsky >= 70% at the time of entry into the study Karnofsky Performance Status score ? 70 Karnofsky performance score >= 60 Karnofsky score > 50% Performance status: Karnofsky score < 60 for adult patients Karnofsky Performance Score ?50% Karnofsky performance score 60 Karnofsky Performance Score < 60. Subjects ? 16 years: Karnofsky score ? 70%. Karnofsky Performance Score of at least 70. Karnofsky performance score < 60 Performance score of at least 80% by Karnofsky Karnofsky performance score 70 or above Karnofsky performance score at least 70% Karnofsky performance status score >= 80% Karnofsky performance score ?70. ECOG score greater than 1 (Karnofsky < 70%) Karnofsky performance score ?60 Karnofsky performance status score >= 60 Patient has a Karnofsky Performance Status score of ?70 Adequate performance status (Karnofsky score >/= 70%) All patients must have a projected survival time of at least 12 weeks and a Karnofsky performance score: >60% (or Zubrod score of >2). Karnofsky score >= 60% Karnofsky performance score >= 50% Have a Karnofsky score >= 70 Have a Karnofsky performance status score of >= 50 Karnofsky score >= 70% at the time of screening Adequate performance status defined as a Karnofsky score >= 70% Adequate performance status, defined as Karnofsky score greater than 70%; Karnofsky score >= 70% Have a Karnofsky performance status score of > 50% Karnofsky score >= 70% Karnofsky performance status score >= 60% Karnofsky performance status score >= 60% Karnofsky score < 60 for adult patients Karnofsky score >= 70% Karnofsky performance status score > 60 Karnofsky performance score over 60 Karnofsky Performance Score of ?60. Karnofsky score > 50 or Patients must have a Karnofsky performance score of 70% or above Karnofsky performance score < 70% Karnofsky Performance Score < 70% Karnofsky performance score >= 70 within 45 days prior to entry Karnofsky performance score of at least 80 Karnofsky score of 60 or higher Karnofsky performance score >= 60 Karnofsky score of >= 60 Karnofsky performance score >= 70 Karnofsky performance score >= 70 Have Karnofsky performance status score ? 70. Lansky performance status score >= 70 for patients =< 16 years of age Karnofsky performance status score >= 70 for patients > 16 years of age Lansky performance status score >= 50 for patients =< 16 years of age; Karnofsky performance status score >= 50 for patients > 16 years of age Performance status\r\n* Phase I: Karnofsky performance scale (KPS for > 16 years of age) or Lansky performance score (LPS for =< 16 years of age) assessed within one week of enrollment must be >= 50\r\n* Surgical study: Karnofsky performance scale (KPS for > 16 years of age) or Lansky performance score (LPS for =< 16 years of age) assessed within one week of enrollment must be >= 60\r\n* Patients who are unable to walk because of neurologic deficits, but who are up in a wheelchair, will be considered ambulatory for the purpose of assessing the performance score Have a Lansky score ? 40 for subjects up to 16 years of age or a Karnofsky score ? 40 for subjects 16 years of age to < 18 years Lansky (for research participants =< 16 years) or Karnofsky (for research participants > 16 years) performance score >= 40 at the time of study enrollment Performance status Lansky (age < 16) or Karnofsky score (age >= 16) >= 80% Karnofsky performance scale ([KPS] for > 16 yrs of age) or Lansky performance score ([LPS] for =< 16 years of age) >= 50 Karnofsky performance scale (KPS for >= 16 years of age) or Lansky performance score (LPS for =< 15 years of age) >= 60 assessed within 14 days prior to registration Lansky Play Scale ?50 for participants from 6 months up to and including 16 years of age; or Karnofsky score ?50 for participants >16 years of age Karnofsky performance scale (KPS for > 16 years of age) or Lansky performance score (LPS for =< 16 years of age) assessed within two weeks of enrollment must be >= 60 Performance status: Lansky Play-Performance Scale ?50 for children up to and including 16 years of age OR Karnofsky score ?50 for participants >16 years of age Performance score > 70% (use Lansky score for age < 16 and Karnofsky score for age >= 16) The participant has a Lansky (<16 years of age) or Karnofsky (?16 years of age) performance score of at least 50. Karnofsky performance scale (KPS for > 16 years [yrs.] of age) or Lansky performance score (LPS for =< 16 years of age) >= 60 assessed within two weeks prior to registration Karnofsky performance status (KPS) of > 60% (KPS for > 10 years of age) or Lansky performance Score (LPS) of >= 60 (LPS for =< 10 years of age) assessed within 2 weeks prior to registration; patients who are unable to walk because of paralysis but who are up in a wheel chair will be considered ambulatory for the purposes of the performance score Subject has Karnofsky (age ? 16 years) or Lansky (age < 16 years) performance status score ? 50 at screening Karnofsky performance status >= 80% for patients >= 16 years of age or Lansky play score >= 80 for patients < 16 years of age\r\n* Note: if poor performance status is due to lymphoma - Karnofsky performance status (KPS) >= 60% or Lansky performance score (LPS) >= 60 is acceptable Performance score of at least 80% by Karnofsky or performance score (PS) < 3 (Eastern Cooperative Oncology Group [ECOG]) (age >= 12 years), or Lansky play-performance scale of at least 60% or greater (age < 12 years). Adequate performance status is defined as Karnofsky score >= 70% (> 16 years of age) or Lansky score >= 70 (pediatrics) Performance level: \r\n* Lansky score >= 60% (patients < 16 years of age)\r\n* Karnofsky score >= 60% (patients >= 16 years of age) Karnofsky score of >= 50 for patients > 16 years of age; or Lansky score of >= 50 for patients =< 16 years of age Karnofsky performance status score (age >= 16 years) or Lansky play score (age < 16 years) =< 40% Adequate performance status is defined as Karnofsky score >= 70% (>= 16 years of age) or Lansky score >= 50 (pediatrics) Age 0 to 70 years of age with Karnofsky score >= 70% (>= 16 years) or Lansky score >= 50 (< 16 years) Karnofsky Performance Score (KPS) >= 50% for patients >= 10 years of age; Lansky score of >= 50 for children < 10 years of age Performance score of at least 70% by Karnofsky or 0 to 1 by Eastern Cooperative Oncology Group (ECOG) (age >= 12 years), or Lansky Play-performance scale of at least 70% or greater (age < 12 years) The patient must be in adequate general condition for study, with Lansky or Karnofsky performance score of >= 50 at study entry; Lansky performance scale will be used for patients =< 16 years of age Karnofsky performance scale (KPS for > 16 years of age) or Lansky performance score (LPS for =< 16 years of age) >= 50 assessed within 2 weeks prior to registration Adequate performance status; Lansky score >= 60% for children < 16 years of age, or Karnofsky score >= 60% for those > 16 years of age Adequate performance status is defined as Karnofsky score >= 60% (> 16 years of age) or Lansky score >= 50 (pediatrics) Performance level: Performance score ?50%. Karnofsky (for participants >16 years of age) or Lansky (for participants ?16 years of age) Subject has a Karnofsky score of ? 50% (subjects ? 16 years of age) or a Lansky score ? 50% (subjects < 16 years of age). Karnofsky performance scale (KPS for > 16 years of age) or Lansky performance score (LPS for =< 16 years of age) assessed within 14 days of enrollment must be >= 50 Lansky (for participants 10 years of age or younger) or Karnofsky (for participants older than 10 years) performance score greater than 50 Karnofsky performance scale (KPS for >= 16 years [yrs] of age) or Lansky performance score (LPS for < 16 years of age) >= 60 assessed within two weeks prior to registration Performance score >= 50 (Lansky for research participants =< 16 years and Karnofsky for those > 16 years) Performance score of >= 60 by Karnofsky or performance score (PS) 0 to 2 (Eastern Cooperative Oncology Group [ECOG]) (age > 12 years), or Lansky play-performance scale >= 60 or greater (age < 12 years) Performance Status: Eastern Cooperative Oncology Group (ECOG) score ? 3 (age ?16) or Lansky Performance Score (LPS) ?40% (age<16). If enrolled with primary CNS tumor to be assessed by RANO, Karnofsky Performance Status (KPS) (age ?16) or LPS (age<16) ? 50% Patients must have a Karnofsky performance scores (KPS) of at least 70 at the first postoperative visit; patients under 18 years of age must have a Lansky performance score of at least 70 Lansky performance score >= 50% for patients =< 16 years of age, or Zubrod performance status score of 0-2 for patients > 16 years of age Performance score of at least 60% by Karnofsky or performance status (PS) less than 3 (Eastern Cooperative Oncology Group [ECOG]) (age greater than or equal to 12 years), or Lansky play-performance scale of at least 60% or greater (age < 12 years) Karnofsky performance scale (KPS for > 16 years of age) or Lansky performance score (LPS for =< 16 years of age) assessed within two weeks of registration must be >= 60 Performance status: Karnofsky (for participants >/= 16 years of age) or Lansky (for participants < 16 years of age) score of >/= 60 Performance score of at least 80% by Karnofsky or performance status (PS) < 3 (Eastern Cooperative Oncology Group [ECOG]) (age >= 12 years), or Lansky Play-Performance scale of at least 60% or greater (age < 12 years) Karnofsky performance status score ? 50 for patients >16 years of age Lansky performance status score ? 50 for patients ? 16 years of age Patients must have a life expectancy of at least 8 weeks and a Lansky (< 16 years age) or Karnofsky (> 16 years age) score of at least 50 Has a Lansky Play Performance score ?60 (participants ?16 years of age) or a Karnofsky score ?60 (participants >16 years of age) Patients with Lansky (age < 16 years) or Karnofsky (age >= 16 years) score < 50 will be excluded The subject has a KPS ? 70 Subject has a KPS ? 60. Subjects must have a Karnofsky score (KPS) of ? 60 at Screening. KPS of ? 70 or ECOG of 0 to 1 Modified KPS of < 80% KPS ? 60 KPS >= 70% KPS >= 70% Patients aged 60 to 65 years must have a KPS of >= 80% and an HCT-CI score of 4 or less Patients aged 66 to 69 years must have a KPS of 90% and an HCT-CI score of 3 or less Patients aged 70 years or more must have a KPS of 90% and an HCT-CI score of 2 or less KPS performance >= 70% Patients must have adequate Karnofsky performance status (KPS) and hematopoietic cell transplantation comorbidity index (HCT-CI) scores:\r\n* Patients < age 60 years must have a KPS of >= 80% and an HCT-CI score of 5 or less\r\n* Patients aged 60 to 65 years must have a KPS of >= 80% and an HCT-CI score of 4 or less\r\n* Patients aged 66 to 69 years must have a KPS of 90% and an HCT-CI score of 3 or less\r\n* Patients aged 70 years or more must have a KPS of 90% and an HCT-CI score of 2 or less Patients must have KPS >/=70 KPS Score < 60 (See \Definitions\ below) KPS equal to or greater than 70 KPS < 70 RPA class III (KPS < 70) Patients must have a Karnofsky performance status (KPS) rating of >= 60 prior to initiating treatment; patients may be enrolled at a KPS of < 60 if it is felt that the patient will have adequate opportunity to recover to a KPS >= 60 by the initiation of treatment KPS > 70 Karnofsky performance status (KPS) >= 70% at time of enrollment; an exception will be made for those with lower KPS at enrollment with an acute worsening that is likely to resolve in the treating physicians judgment (e.g., reversible infection, trauma, medication reaction, etc) KPS 70% or greater KPS ?70. KPS must have been stable during the period from wash-out of prior therapy to randomization. A declining KPS is defined by reduction of 10 points or more over at least a 28-day period. Modified KPS of < 80% KPS 3 or worse KPS equal to or greater than 70 KPS >/= 70 KPS 60% or higher KPS>70 Have KPS of ?60% KPS < 80 RPA class III (KPS < 70%) KPS: at least 70 KPS Score < 60 (See \Definitions\ below) Has a KPS score of >= 50 KPS < 60%