TUMOR BIOPSY SEQUENCING: Human immunodeficiency virus (HIV)-positive patients on combination antiretroviral therapy are ineligible
700.0
Human immunodeficiency virus (HIV) negative
348.0
Patients with known human immunodeficiency virus (HIV) infection are excluded
747.0
No human immunodeficiency virus (HIV) infection; patients with immune dysfunction are at a significantly higher risk of toxicities from intensive immunosuppressive therapies
747.0
Patients with known human immunodeficiency virus (HIV) must have a CD4 count > 350 and be on concurrent antiretrovirals; patients with a history of intravenous drug abuse or any behavior associated with an increased risk of HIV infection should be tested for exposure to the HIV virus; an HIV test is not required for entry on this protocol, but is required if the patient is perceived to be at risk
100.0
Patients must not have any known immune deficiencies; patients with immune deficiency are at increased risk of lethal infections when treated with marrow-suppressive therapy; therefore, known human immunodeficiency virus (HIV) positive patients receiving combination anti-retroviral therapy are excluded from the study
162.0
Patients must not be known to be human immunodeficiency virus (HIV)-positive
155.0
PROCUREMENT: Patients with active human immunodeficiency virus (HIV) positive at time of procurement (can be pending at the time of blood draw)
44.0
Patients with a known active infection, e.g., hepatitis B virus or hepatitis C virus; human immunodeficiency virus (HIV)-positive patients who are otherwise well and who do not have evidence of significant immune compromise are eligible
107.0
Human immunodeficiency virus (HIV) positive patients who are not on retroviral therapy will not be excluded from cohort 1, the normal liver function cohort* HIV positive patients who are not on retroviral therapy will be excluded from cohorts 2-4
80.0
Human immunodeficiency virus (HIV)-positive patients
12.0
Patients that are known to be positive for human immunodeficiency virus (HIV) are not eligible; note: inclusion of HIV positive patients will be considered at a later date
140.0
Known human immunodeficiency virus (HIV) infected patients (HIV testing will not be performed as a part of screening) on combination antiretroviral therapy are eligible for inclusion; the use of zidovudine is not allowed
63.0
Patients with known human immunodeficiency virus (HIV) infection
598.0
Patients must not have known human immunodeficiency virus (HIV) infection or active hepatitis B or C infections
28.0
Human immunodeficiency virus (HIV)-positive patients on highly active antiretroviral therapy (HAART) are excluded
44.0
Patients with known human immunodeficiency virus infection are not to be enrolled in the study
57.0
Patients with known human immunodeficiency virus (HIV) or hepatitis B or C are excluded
484.0
Patients known to be positive for human immunodeficiency virus (HIV) are not eligible
600.0
Individuals who are known to be human immunodeficiency virus (HIV) infected are eligible (note: HIV testing is not required for entry into the study)
300.0
Human immunodeficiency virus (HIV) positive patients will be excluded
52.0
Patients with known history of testing positive for human immunodeficiency virus (HIV) or known acquired immunodeficiency syndrome (AIDS) might be enrolled if the viral load by PCR is undetectable with/without active treatment and absolute lymphocyte count >= 350/ul
80.0
Patients with human immunodeficiency virus (HIV) infection are ineligible
400.0
Patients with human immunodeficiency virus (HIV) are excluded
75.0
Known human immunodeficiency virus (HIV)-positive individuals are ineligible
549.0
Known human immunodeficiency virus (HIV)-positive individuals are ineligible
680.0
History of human immunodeficiency virus (HIV) infection
46.0
Patients should be excluded if they have known history of testing positive for human immunodeficiency virus (HIV) or known acquired immunodeficiency syndrome (AIDS)
29.0
Patients must not have known history of testing positive for human immunodeficiency virus (HIV) or known acquired immunodeficiency syndrome (AIDS)
350.0
Human immunodeficiency virus (HIV) infection
84.0
No known evidence of human immunodeficiency virus (HIV) infection
766.0
Patients with known human immunodeficiency virus (HIV), hepatitis B or C infections; testing to prove negative status is not required for enrollment unless it is deemed necessary for usual medical care of the patient
53.0
Patients with a known history of human immunodeficiency virus (HIV) must have CD4 count >= institutional lower limit of normal within 28 days prior to registration
94.0
Patient who are known to be serologically positive for human immunodeficiency virus (HIV)
49.0
Human immunodeficiency virus (HIV)-positive patients on combination antiretroviral therapy are ineligible; however, HIV-positive patients without an acquired immune deficiency syndrome (AIDS)-defining diagnosis who are not receiving agents with the potential for pharmacokinetic (PK) interactions with ABT-888 may be eligible
276.0
Known human immunodeficiency virus (HIV)-positive patients on combination antiretroviral therapy are ineligible
30.0
Human immunodeficiency virus (HIV)-positive patients on combination antiretroviral therapy are not eligible
110.0
Human immunodeficiency virus (HIV)-positive patients on combination antiretroviral therapy are ineligible
55.0
Human immunodeficiency virus (HIV)-positive patients on combination antiretroviral therapy are ineligible
36.0
Human immunodeficiency virus (HIV)-positive patients on combination antiretroviral therapy are ineligible
140.0
Known human immunodeficiency virus (HIV)-positive patients on combination antiretroviral therapy are ineligible
72.0
Known human immunodeficiency virus (HIV) or other history of immunodeficiency disorder; HIV-positive patients on combination antiretroviral therapy are ineligible
80.0
HIV-positive patients on combination antiretroviral therapy are ineligible
30.0
Human immunodeficiency virus (HIV)-positive patients on combination antiretroviral therapy are ineligible
73.0
HIV-positive patients on combination antiretroviral therapy are ineligible
80.0
Human immunodeficiency virus (HIV)-positive patients on combination antiretroviral therapy are ineligible
70.0
Human immunodeficiency virus (HIV) positive patients on antiretroviral therapy are ineligible
72.0
TREATMENT: HIV-positive patients on combination antiretroviral therapy are ineligible
700.0
Human immunodeficiency virus (HIV)-positive patients on combination antiretroviral therapy are ineligible
40.0
Human immunodeficiency virus (HIV)-positive patients on combination antiretroviral therapy are ineligible; it is not necessary to conduct HIV testing at screening; patients who are HIV-positive with undetectable viral loads, not on interacting antiretroviral therapy, and have CD4 counts above 300/mm^3 may be eligible after discussion with the principal investigator
68.0
HIV-positive patients on combination antiretroviral therapy are ineligible
68.0
Patients known to be human immunodeficiency virus (HIV)-positive patients and on combination antiretroviral therapy are ineligible
32.0
Human immunodeficiency virus (HIV)-positive patients on combination antiretroviral therapy are ineligible
100.0
Human immunodeficiency virus (HIV)-positive patients on combination antiretroviral therapy are ineligible
24.0
Human immunodeficiency virus (HIV)-positive patients on combination antiretroviral therapy are ineligible
35.0
Human immunodeficiency virus (HIV)-positive patients on combination antiretroviral therapy are ineligible
40.0
HIV-positive patients on combination antiretroviral therapy are ineligible
35.0
Human immunodeficiency virus (HIV)-positive subjects on combination antiretroviral therapy are ineligible
340.0
Human immunodeficiency virus (HIV)-positive patients on combination antiretroviral therapy are ineligible
90.0
Human immunodeficiency virus (HIV)-positive patients on combination antiretroviral therapy are ineligible
23.0
Human immunodeficiency virus (HIV)-positive patients on combination antiretroviral therapy are ineligible
18.0
Patients who are known to have human immunodeficiency virus (HIV) or are on combination antiretroviral therapy are ineligible
60.0
Human immunodeficiency virus (HIV)-positive patients on combination antiretroviral therapy are ineligible
66.0
Human immunodeficiency virus (HIV)-positive patients on combination antiretroviral therapy are ineligible
58.0
Patients who are known to have human immunodeficiency virus (HIV) or are on combination antiretroviral therapy are ineligible
126.0
Patient does not have known human immunodeficiency virus syndrome (HIV, testing optional); known HIV-positive patients receiving combination antiretroviral therapy are ineligible
188.0
Human immunodeficiency virus (HIV)-positive patients on combination antiretroviral therapy are ineligible
82.0
Human immunodeficiency virus (HIV)-positive patients on combination antiretroviral therapy are ineligible
126.0
Human immunodeficiency virus (HIV)-positive patients on combination antiretroviral therapy known to interact with CYP isoenzymes are ineligible; in addition, HIV patients with CD4 count < 200 cells/uL are ineligible; appropriate studies will be undertaken in patients receiving combination antiretroviral therapy when indicated
37.0
Human immunodeficiency virus (HIV)-positive patients on combination antiretroviral therapy are ineligible
36.0
Patients with human immunodeficiency virus (HIV) on antiretroviral therapy are ineligible
50.0
Patients who are known to be human immunodeficiency positive (HIV)-positive and are on combination antiretroviral therapy are ineligible
15.0
Human immunodeficiency virus (HIV)-positive patients on combination antiretroviral therapy are ineligible
46.0
Human immunodeficiency virus (HIV)-positive patients on combination antiretroviral therapy are ineligible
180.0
Human immunodeficiency virus (HIV)-positive patients on combination antiretroviral therapy are ineligible
46.0
Human immunodeficiency virus (HIV)-positive patients on combination antiretroviral therapy are ineligible; appropriate studies will be undertaken in patients receiving combination antiretroviral therapy when indicated
70.0
Human immunodeficiency virus (HIV)-positive patients on combination antiretroviral therapy are ineligible; appropriate studies will be undertaken in patients receiving combination antiretroviral therapy when indicated
48.0
Human immunodeficiency virus (HIV)-positive subjects on combination antiretroviral therapy are ineligible
60.0
Human immunodeficiency virus (HIV)-positive patients on combination antiretroviral therapy are ineligible; patients must also have a CD4 count > 350 cells/mm^3 with an undetectable viral load
35.0
Human immunodeficiency virus (HIV)-positive patients on combination antiretroviral therapy are ineligible; appropriate studies will be undertaken in patients receiving combination antiretroviral therapy when indicated
28.0
Human immunodeficiency virus (HIV)-positive patients are ineligible; appropriate studies will be undertaken in patients receiving combination antiretroviral therapy when indicated
180.0
Human immunodeficiency virus (HIV)-positive patients on combination antiretroviral therapy are INELIGIBLE
40.0
Human immunodeficiency virus (HIV)-positive patients on combination antiretroviral therapy are ineligible
132.0
Human immunodeficiency virus (HIV)-positive patients on combination antiretroviral therapy are ineligible
40.0
Human immunodeficiency virus (HIV)-positive patients on combination antiretroviral therapy are ineligible; appropriate studies will be undertaken in patients receiving combination antiretroviral therapy when indicated
70.0
Human immunodeficiency virus (HIV)-positive patients on combination antiretroviral therapy are ineligible
30.0
Human immunodeficiency virus (HIV)-positive patients on combination antiretroviral therapy are ineligible due to potential drug-drug interactions with PT2385
35.0
HIV-1 infection, documented by any licensed rapid HIV test or HIV enzyme or chemiluminescence immunoassay (E/CIA) test kit at any time prior to study entry and confirmed by a licensed Western blot or a second antibody test by a method other than the initial rapid HIV and/or E/CIA, or confirmed by HIV-1 antigen or plasma HIV-1 ribonucleic acid (RNA) viral load > 1,000 copies/mL* NOTE: the term licensed refers to a United States (U.S.) Food and Drug Administration (FDA)-approved kit or for sites located in countries other than the United States, a kit that has been certified or licensed by an oversight body within that country and validated internally* WHO (World Health Organization) and CDC (Centers for Disease Control and Prevention) guidelines mandate that confirmation of the initial test result must use a test that is different from the one used for the initial assessment; a reactive initial rapid test should be confirmed by either another type of rapid assay or an E/CIA that is based on a different antigen preparation and/or different test principle (e.g., indirect versus competitive), or a Western blot or a plasma HIV-1 RNA viral load
90.0
HIV positive; documentation of HIV-1 infection by means of any one of the following:* Documentation of HIV diagnosis in the medical record by a licensed health care provider;* Documentation of receipt of antiretroviral therapy (ART) by a licensed health care provider;* HIV-1 RNA detection by a licensed HIV-1 RNA assay demonstrating > 1000 RNA copies/mL;* Any licensed HIV screening antibody and/or HIV antibody/antigen combination assay confirmed by a second licensed HIV assay such as a HIV-1 western blot confirmation or HIV rapid multispot antibody differentiation assay* NOTE: A �licensed� assay refers to a United States (US) Food and Drug Administration (FDA)-approved assay, which is required for all investigational new drug (IND) studies
70.0
Serologic documentation of HIV infection at any time prior to study entry, as evidenced by positive enzyme-linked immunosorbent assay (ELISA), positive western blot, or any other federally approved licensed HIV test; alternatively, this documentation may include a record that another physician has documented that the participant has HIV infection based on prior ELISA and western blot, or other approved diagnostic tests
42.0
HIV-positive; documentation of HIV-1 infection by means of any one of the following: * Documentation of HIV diagnosis in the medical record by a licensed health care provider* Documentation of receipt of antiretroviral therapy (ART) (at least two different medications) by a licensed health care provider (documentation may be a record of an ART prescription in the participant�s medical record, a written prescription in the name of the participant for ART, or pill bottles for ART with a label showing the participant�s name)* HIV-1 ribonucleic acid (RNA) detection by a licensed HIV-1 RNA assay demonstrating > 1000 RNA copies/mL* Any licensed HIV screening antibody and/or HIV antibody/antigen combination assay confirmed by a second licensed HIV assay such as a HIV-1 Western blot confirmation or HIV rapid multispot antibody differentiation assayNOTE: A �licensed� assay refers to a United States (U.S.) Federal Drug Administration (FDA)-approved assay, which is required for all investigational new drug (IND) studies
150.0
HIV positive; documentation of HIV-1 infection by means of any one of the following:* Documentation of HIV diagnosis in the medical record by a licensed health care provider;* Documentation of receipt of antiretroviral therapy (ART) by a licensed health care provider (documentation may be a record of an ART prescription in the participant�s medical record, a written prescription in the name of the participant for ART, or pill bottles for ART with a label showing the participant�s name; receipt of at least two agents is required; each component agent of a multi-class combination ART regimen will be counted toward the 2-agent requirement, excepting receipt of a pre-exposure prophylaxis [PrEP] regimen alone [e.g., Truvada], which is exclusionary);* HIV-1 ribonucleic acid (RNA) detection by a licensed HIV-1 RNA assay demonstrating > 1000 RNA copies/mL;* Any licensed HIV screening antibody and/or HIV antibody/antigen combination assay confirmed by a second licensed HIV assay such as a HIV-1 western blot confirmation or HIV rapid multispot antibody differentiation assay* NOTE: A �licensed� assay refers to a United States (US) Food and Drug Administration (FDA)-approved assay, which is required for all investigational new drug (IND) studies
5058.0
HIV positive; documentation of HIV-1 infection by means of any one of the following:* Documentation of HIV diagnosis in the medical record by a licensed health care provider;* Documentation of receipt of antiretroviral therapy (ART) by a licensed health care provider (documentation may be a record of an ART prescription in the participant�s medical record, a written prescription in the name of the participant for ART, or pill bottles for ART with a label showing the participant�s name; receipt of at least two agents is required; each component agent of a multi-class combination ART regimen will be counted toward the 2-agent requirement, excepting receipt of a pre-exposure prophylaxis [PrEP] regimen alone [e.g., Truvada], which is exclusionary);* HIV-1 ribonucleic acid (RNA) detection by a licensed HIV-1 RNA assay demonstrating > 1000 RNA copies/mL* Any licensed HIV screening antibody and/or HIV antibody/antigen combination assay confirmed by a second licensed HIV assay such as a HIV-1 western blot confirmation or HIV rapid multispot antibody differentiation assay** NOTE: A �licensed� assay refers to a United States (U.S.) Food and Drug Administration (FDA)-approved assay, which is required for all investigational new drug (IND) studies
56.0
Documentation of HIV status; if participant is HIV positive, HIV-1 infection, as documented by any federally approved, licensed HIV rapid test performed in conjunction with screening (or enzyme-linked immunosorbent assay [ELISA] test kit, and confirmed by Western blot or other approved test, or HIV rapid multispot antibody differentiation assay); alternatively, this documentation may include a record demonstrating that another physician has documented the participant's HIV status based on either: 1) approved diagnostic tests, or 2) the referring physician's written record that HIV infection was documented, with supporting information on the participant's relevant medical history and/or current management of HIV infection* If the participant is HIV negative, documentation of a negative result for any federally approved, licensed HIV rapid test within 4 weeks prior to study enrollment will suffice; if the initial rapid test is positive, further approved confirmatory test results must be present to document the subject�s HIV status
42.0
HIV-1 infection, as documented by any federally approved, licensed HIV rapid test performed in conjunction with screening (or enzyme linked immunosorbent assay [ELISA], test kit, and confirmed by Western blot or other approved test); alternatively, this documentation may include a record demonstrating that another physician has documented the participant's HIV status based on either: 1) approved diagnostic tests, or 2) the referring physician's written record that HIV infection was documented, with supporting information on the participant�s relevant medical history and/or current management of HIV infection
84.0
HIV-1 infection, as documented by any federally approved, licensed HIV rapid test performed in conjunction with screening (or enzyme linked immunosorbent assay [ELISA], test kit, and confirmed by western blot or other approved test); alternatively, this documentation may include a record demonstrating that another physician has documented the participant's HIV status based on either: 1) approved diagnostic tests, or 2) the referring physician's written record that HIV infection was documented, with supporting information on the participant's relevant medical history and/or current management of HIV infection
18.0
Known human immunodeficiency virus (HIV)-1 infection status, as documented by any nationally approved, licensed HIV rapid test performed in conjunction with screening (or enzyme-linked immunosorbent assay [ELISA], test kit, and confirmed by approved test at each study site; United States (U.S.) participants only: alternatively, this documentation may include a record demonstrating that another physician has documented the participant's HIV status based on either:* Approved diagnostic tests, or* The referring physician's written record that HIV infection was documented, with supporting information on the participant's relevant medical history and/or current management of HIV infection** Participants enrolled outside the U.S. must have a confirmatory diagnostic test sequence as appropriate per national standards, detailed as above, performed regardless of prior documented HIV status; for HIV-negative participants, testing must be performed no more than 1 month prior to study enrollment; NOTE: the term �licensed� refers to a U.S. Food and Drug Administration (FDA)-approved kit or for sites located in countries other than the United States, a kit that has been certified or licensed by an oversight body within that country and validated internally; WHO (World Health Organization) and CDC (Centers for Disease Control and Prevention) guidelines mandate that confirmation of the initial test result must use a test that is different from the one used for the initial assessment; a reactive initial rapid test should be confirmed by either another type of rapid assay or an enzyme/chemiluminescence immunoassay (E/CIA) that is based on a different antigen preparation and/or different test principle (e.g., indirect versus competitive), or a Western blot or a plasma HIV-1 ribonucleic acid (RNA) viral load
36.0
Immunocompromised patients (other than that related to the use of corticosteroids) including patients known to be human immunodeficiency virus (HIV) positive
102.0
Patients known to be human immunodeficiency virus (HIV) positive and currently receiving retroviral therapy are not eligible; note: patients known to be HIV positive, but without clinical evidence of an immunocompromised state, are eligible for the study
360.0
Immunocompromised patients (other than that related to the use of corticosteroids) with the exception of patients known to be human immunodeficiency virus (HIV) positive and have a cluster of differentiation 4 (CD4) count > 400 and do not require antiretroviral therapy
102.0
Immunocompromised patients (other than that related to the primary oncologic diagnosis or to the use of corticosteroids) including patients known to be human immunodeficiency virus (HIV) positive are not eligible
67.0
Human immunodeficiency virus (HIV) positive patients are allowed on this study if they have a CD4 count > 400, and are on a stable antiviral regimen; patients with poorly controlled HIV or other chronic active viral infections will be excluded
189.0
Patients who are human immunodeficiency virus (HIV) positive on highly active anti-retroviral therapy (HAART) will be excluded from the study
33.0
Patients with concurrent human immunodeficiency virus (HIV) infection may be enrolled if compliant with 3 or more drug anti-retroviral regimen and virus load less than 50 copies/ml and CD4 count greater than 250 cells/ml, and no concurrent opportunistic infection or other malignancy
20.0
Patients positive for human immunodeficiency virus (HIV) are NOT excluded from this study, but HIV-positive patients must have:* A stable regimen of highly active anti-retroviral therapy (HAART)* No requirement for concurrent antibiotics or antifungal agents for the prevention of opportunistic infections* A cluster of differentiation (CD)4 count above 250 cells/mcL and an undetectable HIV viral load on standard PCR-based tests
488.0
Patients positive for human immunodeficiency virus (HIV) are eligible only if they have all of the following:* A stable regimen of highly active anti-retroviral therapy (HAART)* No requirement for concurrent antibiotics or antifungal agents for the prevention of opportunistic infections* A CD4 count above 250 cells/mcL and an undetectable HIV viral load on standard PCR-based tests
148.0
Patients positive for human immunodeficiency virus (HIV) are NOT excluded from this study, but HIV-positive patients must have:* A stable regimen of highly active anti-retroviral therapy (HAART)* No requirement for concurrent antibiotics or antifungal agents for the prevention of opportunistic infections* A CD4 count above 250 cells/mcL and an undetectable HIV viral load on standard polymerase chain reaction (PCR)-based test
72.0
Patients who have previously tested positive for human immunodeficiency virus (HIV) are NOT excluded from this study (please note: testing of all patients wishing to enroll is NOT required), but HIV-positive patients must have:* A stable regimen of highly active anti-retroviral therapy (HAART)* No requirement for concurrent antibiotics or antifungal agents for the prevention of opportunistic infections* A CD4 count above 250 cells/mcL and an undetectable HIV viral load on standard PCR-based tests
40.0
Patients positive for human immunodeficiency virus (HIV) are NOT excluded from this study, but HIV-positive patients must have:* A stable regimen of highly active anti-retroviral therapy (HAART)* No requirement for concurrent antibiotics or antifungal agents for the prevention of opportunistic infections* A CD4 count above 250 cells/mcL and an undetectable HIV viral load on standard PCR-based tests
60.0
Patients with known active human immunodeficiency virus (HIV) infection; patients with chronic HIV with a CD4 > 250, undetectable viral load by PCR, without opportunistic infection, and on a stable regimen of highly active anti-retroviral therapy (HAART) therapy would be eligible
48.0
Patients positive for human immunodeficiency virus (HIV) are eligible only if they meet all of the following:* A stable regimen of highly active anti-retroviral therapy (HAART)* No requirement for concurrent antibiotics or antifungal agents for the prevention of opportunistic infections* A CD4 count above 250 cells/mcL, and an undetectable HIV viral load on standard PCR-based tests
700.0
Patients positive for human immunodeficiency virus (HIV) are NOT excluded from this study, but HIV-positive patients must have:* A stable regimen of highly active anti-retroviral therapy (HAART)* No requirement for concurrent antibiotics or antifungal agents for the prevention of opportunistic infections* A CD4 count above 250 cells/mcL and an undetectable HIV viral load on standard PCR-based tests
22.0
Patients who are human immunodeficiency virus (HIV) positive may participate IF they meet the following eligibility requirements:* They must be stable on their anti-retroviral regimen, and they must be healthy from an HIV perspective* They must have a CD4 count of greater than 250 cells/mcL* They must not be receiving prophylactic therapy for an opportunistic infection
27.0
Human immunodeficiency virus (HIV)-patients positive for human immunodeficiency virus (HIV) are NOT excluded from this study, however HIV-positive patients must meet the following criteria:* A stable regimen of highly active anti-retroviral therapy (HAART)* No requirement for concurrent antibiotics or antifungal agents for the prevention of opportunistic infections* A CD4 count above 250 cells/mcL and an undetectable HIV viral load on standard polymerase chain reaction (PCR)-based test
27.0
Patients positive for human immunodeficiency virus (HIV) are NOT excluded from this study, but HIV-positive patients must have:* A stable regimen of highly active anti-retroviral therapy (HAART)* No requirement for concurrent antibiotics or antifungal agents for the prevention of opportunistic infections* A CD4 count above 250 cells/mcL and an undetectable HIV viral load on standard PCR-based tests
78.0
Patients with known human immunodeficiency virus (HIV) positive must have a cluster of differentiation (CD)4 cell count be >= 350 cells/mm^3 within 14 days prior to study entry (note, however, that HIV testing is not required for entry into this protocol)
285.0
Patients with active human immunodeficiency virus (HIV) infection are eligible if their cluster of differentiation (CD)4 count is > 499/cu mm and their viral load is < 50 copies/ml; use of highly active antiretroviral treatment (HAART) is allowed
545.0
Human immunodeficiency virus (HIV)-positive patients on combination antiretroviral therapy will be eligible unless the cluster of differentiation (CD)4 count is < 200 cells/mm^3 within one month of study enrollment
40.0
Human immunodeficiency virus (HIV)-positive patients who are not receiving: agents with the potential for PK interactions with romidepsin or hepatotoxic antiretrovirals (nucleoside reverse-transcriptase inhibitors [NRTIs]: abacavir, didanosine, emtricitabine, lamivudine, stavudine, and zidovudine), dual protease inhibitor (PI)-based regimens except low-dose boosting with ritonavir, atazanavir, indinavir, maraviroc, and nevirapine may be eligible; additionally, the HIV-positive patients should have a cluster of differentiation (CD)4 count > 250/mm^3; if the specific cause of hepatic dysfunction is unknown, the patient should be worked up for other viral causes of hepatitis and their eligibility determined after consultation with the principal investigator
132.0
Patients with human immunodeficiency virus (HIV) who are not receiving cytochrome p450 inhibitors, and who have a minimum of 300+ CD4+ cells/mm^3, an undetectable viral load, and no history of acquired immune deficiency syndrome (AIDS) indicator conditions
24.0
HIV-positive patients on combination antiretroviral therapy which include cytochrome p450 inhibitors are ineligible; patients with CD4 counts less than 300 CD4+ cells/mm^3 and or a high viral load are ineligible
24.0
Patients who are known to be human immunodeficiency virus positive (HIV+) are eligible providing they meet all of the following additional criteria within 28 days prior to registration:* Cluster of differentiation (CD)4 cells >= 500/mm^3* Viral load of < 50 copies HIV messenger ribonucleic acid (mRNA)/mm^3 if on combination antiretroviral therapy (cART) or < 25,000 copies HIV mRNA if not on cART* No zidovudine or stavudine as part of cART* Patients who are HIV+ and do not meet all of these criteria are not eligible for this study
130.0
Human immunodeficiency virus (HIV) positive with CD4 count < (350) cells/microliter; note that patients who are HIV positive are eligible, provided they are under treatment with highly active antiretroviral therapy (HAART) and have a CD4 count >= (350) cells/microliter, and no known detectable viral load, at the time of study entry; note also that HIV testing is not required for eligibility for this protocol
368.0
STEP I: Human immunodeficiency virus (HIV) infection is not excluded; known HIV positive patients must meet the following criteria:* Cluster of differentiation (CD)4 cell count >= 350/mm^3* No history of acquired immune deficiency syndrome (AIDS)-related illness* Not currently prescribed zidovudine or stavudine
1080.0
A cluster of differentiation (CD)4+ lymphocyte count > 50/mcL will be required within 2 weeks of study participation
42.0
RANDOMIZED PHASE II (ARMS K AND L): HIV positive patients are eligible provided they meet the other protocol criteria including the following:* Long term survival expected were it not for the cHL* HIV viral loads undetectable by standard clinical HIV testing* Willing to adhere to effective combination antiretroviral therapy
189.0
Patients with human immunodeficiency virus (HIV) are eligible if they are not on antiviral agents and have adequate cluster of differentiation (CD)4 counts (>= 500 mm^3)
97.0
Patients who are known to be human immunodeficiency virus positive (HIV+) are eligible providing they meet all of the following additional criteria within 28 days prior to registration:* CD4+ cells >= 350/mm^3 (nadir)* Viral load of < 50 copies HIV messenger ribonucleic acid (mRNA)/mm^3 if on combination antiretroviral therapy (cART) or < 25,000 copies HIV mRNA if not on cART* No zidovudine or stavudine as part of cARTPatients who are HIV+ and do not meet all of these criteria are not eligible for this study
38.0
Patients with human immunodeficiency virus (HIV) infection are eligible, provided they meet the following:* No history of acquired immunodeficiency syndrome (AIDS)-defining conditions or other HIV related illness* Cluster of differentiation (CD)4+ cells nadirs > 350/mm^3 within 28 days prior to registration* Treatment sensitive HIV and, if on anti-HIV therapy, HIV viral load < 50 copies/mm^3 within 28 days prior to registration* Note: HIV+ patients who enroll on this study and are assigned to treatment with ixazomib may need to modify their anti-retroviral therapy prior to receiving protocol therapy if they are on strong inducers or potent inhibitors of cytochrome P450 3A4
97.0
Human immunodeficiency virus (HIV)-positive patients on antiviral drugs and/or cluster of differentiation (CD)4 count is inadequate (< 500); if neither condition exists, HIV-positive patients are eligible
18.0
Disease must be cluster of differentiation (CD)30 positive
140.0
Patients with known human immunodeficiency virus (HIV) infection are eligible if they meet all of the following criteria:* No history of acquired immune deficiency syndrome (AIDS)-related complications other than a history of low CD4+ T-cell count (< 200/mm^3) prior to initiation of combination antiretroviral therapy; on study CD4+ T-cell count may not be informative due to leukemia and should not be used as an exclusion criterion if low* Patient must be healthy on the basis of HIV disease with high likelihood of near normal life span were it not for the leukemia* Patient must have serum HIV viral load of < 200 copies/mm^3* Patient must be on combination antiretroviral therapy with minimal pharmacokinetic interactions with study therapy and minimal overlapping clinical toxicity with protocol therapy* Patient must not be receiving protease inhibitors or once daily formulations containing cobicistat, stavudine, or on regimens containing stavudine or zidovudine* It is recommended to utilize a regimen of the integrase inhibitor, dolutegravir, combined with either disoproxil fumarate/emtricitabine or dolutegravir combined with tenofovir alafenamide/emtricitabine
509.0
Cluster of differentiation (CD)4 count >= 200 within 120 days prior to enrollment or plasma HIV-1 RNA < 200 copies/mL within 120 days prior to randomization
150.0
Patients with known human immunodeficiency virus (HIV) infection are eligible if not on antiviral agents and cluster of differentiation (CD)4 counts are adequate (>= 500)
68.0
Patients with a known history of human immunodeficiency virus (HIV) seropositivity:* Must have undetectable viral load using standard HIV assays in clinical practice* Must have cluster of differentiation (CD)4 count >= 400/mcL* Must not require prophylaxis for any opportunistic infections (i.e., fungal, Mycobacterium avium complex [mAC], or pneumocystis jiroveci pneumonia [PCP] prophylaxis)* Must not be newly diagnosed within 12 months prior to sub-study registration
10000.0
Patients known to be human immunodeficiency virus (HIV) positive with one or more of the following:* Baseline cluster of differentiation (CD)4 count of < 250 cells/mm^3* History of acquired immune deficiency syndrome (AIDS) indicator conditions* Anti-retroviral therapy with any potent CYP3A4 inhibitor
1500.0
Severe, active co-morbidity, defined as follows:* Unstable angina and/or congestive heart failure requiring hospitalization within the last 6 months prior to registration* Transmural myocardial infarction within the last 6 months prior to registration* Acute bacterial or fungal infection requiring intravenous antibiotics at the time of registration* Chronic obstructive pulmonary disease exacerbation or other respiratory illness requiring hospitalization or precluding study therapy within 30 days prior to registration* Severe hepatic disease, defined as a diagnosis of Child-Pugh class B or C hepatic disease* Human immunodeficiency virus (HIV) positive with cluster of differentiation (CD) 4 count < 200 cells/microliter; note that patients who are HIV positive are eligible, provided they are under treatment with highly active antiretroviral therapy (HAART) and have a CD4 count >= 200 cells/microliter within 30 days prior to registration; note also that HIV testing is not required for eligibility for this protocol* End-stage renal disease (i.e., on dialysis or dialysis has been recommended)
84.0
Known human immunodeficiency virus (HIV)-positive patients should have a cluster of differentiation (CD)4 count > 250/mm^3
600.0
Severe, active co-morbidity, defined as follows:* Unstable angina and/or congestive heart failure requiring hospitalization within the last 6 months* Transmural myocardial infarction within the last 6 months* Acute bacterial or fungal infection requiring intravenous antibiotics at the time of registration* Chronic obstructive pulmonary disease exacerbation or other respiratory illness requiring hospitalization or precluding study therapy within 30 days before registration* Human immunodeficiency virus (HIV) positive with cluster of differentiation (CD)4 count < 200 cells/microliter; note that patients who are HIV positive are eligible, provided they are under treatment with highly active antiretroviral therapy (HAART) and have a CD4 count >= 200 cells/microliter within 30 days prior to registration; note also that HIV testing is not required for eligibility for this protocol* End-stage renal disease (i.e., on dialysis or dialysis has been recommended)
182.0
Patients known to be positive for HIV (the human immunodeficiency virus) may be eligible, providing they meet the following additional criteria within 28 days prior to registration:* No history of acquired immune deficiency syndrome (AIDS)-defining conditions* CD4 cells > 350 cells/mm^3* If on antiretroviral agents, must not include zidovudine or stavudine* Viral load =< 50 copies HIV messenger ribonucleic acid (mRNA)/mm^3 if on combination antiretroviral therapy (cART) or =< 25,000 copies HIV mRNA/mm^3 if not on cART* Highly active antiretroviral therapy (HAART) regimens are acceptable providing they have only weak P450A4 interactions
44.0
Human immunodeficiency virus (HIV)-positive patients on combination antiretroviral therapy are ineligible; if an HIV-positive patient has adequate cluster of differentiation (CD4) counts (CD4 above the lower limit of institutional normal) and is on antiretroviral therapy with newer agents, which are not strong cytochrome (CYP) inhibitors, they will be eligible
23.0
Patients with known human immunodeficiency virus (HIV) may be eligible providing they meet the following additional criteria:* Cluster of differentiation (CD)4 cells >= 500/uL* Serum HIV viral load of < 25,000 IU/ml* No current antiretroviral therapy** Tests must be obtained within 28 days prior to registration; patients who are HIV positive (+) and do not meet all of these criteria are not eligible for this study (HIV/hepatitis testing are not required for patients without known infection)
280.0
Human immunodeficiency virus (HIV) positive with cluster of differentiation (CD)4 count < 200 cells/microliter; note that patients who are HIV positive are eligible, provided they are under treatment with highly active antiretroviral therapy (HAART) and have a CD4 count >= 200 cells/microliter within 30 days prior to registration; note also that HIV testing is not required for eligibility for this protocol
360.0
Patients who are human immunodeficiency virus (HIV) positive may participate if they meet the following eligibility requirements:* They must be stable on their anti-retroviral regimen, and they must be healthy from an HIV perspective* They must have a cluster of differentiation (CD)4 count of greater than 250 cells/mcL* They must not be receiving prophylactic therapy for an opportunistic infection
36.0
Human immunodeficiency virus (HIV)-positive patients are eligible if on stable dose of highly active antiretroviral therapy (HAART), cluster of differentiation (CD)4 counts are greater than 350 and viral load is undetectable
135.0
In order for patients with known history of testing positive for human immunodeficiency virus (HIV) or known acquired immunodeficiency syndrome (AIDS) to be eligible, they must be on a stable highly active antiretroviral therapy (HAART) regimen, have cluster of differentiation (CD)4 counts > 350, with no detectable viral load on quantitative polymerase chain reaction (PCR)
96.0
Human immunodeficiency virus (HIV)-positive patients on combination antiretroviral therapy are eligible provided that they meet the following criteria in addition to the other protocol criteria: * Cancer as the only acquired immunodeficiency syndrome (AIDS)-defining condition* Cluster of differentiation (CD)4 cell count >= 250* Treatment sensitive HIV and prospects for long term survival on the basis of HIV disease alone* Willing to take anti-HIV therapy that will have minimal potential for pharmacokinetic interactions with GDC-0449
12.0
Severe, active co-morbidity defined as follows:* Unstable angina and/or congestive heart failure requiring hospitalization within the last 6 months* Transmural myocardial infarction within the last 6 months* Acute bacterial or fungal infection requiring intravenous antibiotics at the time of registration* Chronic obstructive pulmonary disease exacerbation or other acute respiratory illness precluding study therapy at the time of registration* Severe hepatic disease defined as a diagnosis of Child-Pugh class B or C hepatic disease* Renal tubular acidosis or metabolic acidosis* Human immunodeficiency virus (HIV) positive with CD4 count < 200 cells/microliter; note that patients who are HIV positive are eligible, provided they are under treatment with highly active antiretroviral therapy (HAART) and have a CD4 count >= 200 cells/microliter within 30 days prior to registration; Note also that HIV testing is not required for eligibility for this protocol
510.0
If HIV-positive, any cluster of differentiation (CD)4 count will be allowed on study
42.0
Patients who are human immunodeficiency virus (HIV)-positive are eligible if: * CD4+ cell count greater or equal to 250 cells/mm^3* If patient is on antiretroviral therapy, there must be minimal interactions or overlapping toxicity of the antiretroviral therapy with the experimental cancer treatment; for experimental cancer therapeutics with CYP3A/4 interactions, protease inhibitor therapy is disallowed; suggested regimens to replace protease inhibitor therapy include dolutegravir given with tenofovir/emtricitabine; raltegravir given with tenofovir and emtricitabine; once daily combinations that use pharmacologic boosters may not be used* No history of non-malignancy acquired immune deficiency syndrome (AIDS)-defining conditions other than historical low CD4+ cell counts* Probable long-term survival with HIV if cancer were not present
6452.0
Human immunodeficiency virus (HIV)-positive patients on combination antiretroviral therapy are ineligible; however, HIV patients treated with regimens that have low cytochrome P450 (CYP450) inhibition may be allowed as long as the patient�s general health and cluster of differentiation (CD)4 counts are within acceptable levels
209.0
Patients known to be human immunodeficiency virus (HIV) positive with a baseline cluster of differentiation (CD)4 count of < 250 cells/mm^3 or have a history of acquired immune deficiency syndrome (AIDS) indicator conditions
990.0
Human immunodeficiency virus (HIV)-positive patients on antiretroviral medications that are CYP3A4 substrates will be closely monitored; HIV-positive patients will be excluded if they have a cluster of differentiation 4 (CD4) count < 200
35.0
Human immunodeficiency virus (HIV)-infected persons are eligible if they meet other eligibility criteria including the following:* No prior acquired immune deficiency syndrome (AIDS)-defining condition other than cluster of differentiation (CD)4+ cells nadir < 200/mm^3* Pre-leukemia CD4+ cell count >= 250/mm^3* Willing to adhere to antiretroviral therapy regimen with minimal overlapping toxicity and PK interactions with the experimental agents in this study; no zidovudine- and no ritonavir-containing regimens and no 3-drugs-in-1 pill regimens containing pharmacologic boosters are allowed; recommended regimens are integrase inhibitors combined with tenofovir and emtricitabine
30.0
Human immunodeficiency virus (HIV) positive (+) patients with cluster of differentiation 4 (CD4) counts >= 250 cells/mm^3 on anti-viral therapy
30.0
Human immunodeficiency (HIV) positive (+) patients are eligible provided they meet the other eligibility criteria and:* Cluster of differentiation (CD)4+ cells are >= 250/mm^3* There is no history of acquired immunodeficiency syndrome (AIDS) defining conditions other than historically low CD4+ cell count* The following antiretroviral agents are not allowed: zidovudine, stavudine, protease inhibitors, non-nucleoside reverse transcriptase inhibitors, combination pills with pharmacologic boosters* Recommended antiretroviral regimens to avoid pharmacokinetic (PK) interactions include strand integrase inhibitors with nucleoside reverse transcriptase inhibitors (for example, dolutegravir given with tenofovir and emtricitabine)
110.0
Human immunodeficiency virus (HIV) infected patients are eligible provided they meet all other eligibility criteria, and:* There is no prior history of acquired immunodeficiency syndrome (AIDS) defining conditions other than historically low CD4+ T-cell count or B-cell lymphoma* In the opinion of an expert in HIV disease, prospects for long-term survival are excellent were it not for the diagnosis of lymphoma* Use of HIV protease inhibitors as part of the anti-HIV regimen OR as a pharmacologic booster is not allowed* Zidovudine is not allowed* Once daily combination pills for HIV containing a pharmacologic booster such as cobicistat are not allowed* Patients with multi-drug resistant HIV are not eligible
302.0
Human immunodeficiency virus (HIV) infected patients (if HIV positive)* HIV infected individuals are eligible provided they meet all the protocol eligibility criteria in addition to the following:** No history of acquired immune deficiency syndrome (AIDS) defining illness other than a historic CD4+ T-cell nadir < 200/mm^3** Prior to leukemia diagnosis, the HIV disease was uncomplicated as evidenced by:*** The CD4+ T-cell counts were generally in excess of 300/mm^3*** The HIV viral loads were less than 200 copies/ml if on anti-HIV therapy*** If the HIV is newly diagnosed or there is no history of using anti-HIV therapy, there are no AIDS defining conditions or other HIV-related symptoms*** Zidovudine is not allowed as part of the anti-HIV therapy
35.0
Severe, active comorbidity, defined as follows:* Unstable angina and/or congestive heart failure requiring hospitalization within the last 6 months* Transmural myocardial infarction within the last 6 months* Acute bacterial or fungal infection requiring intravenous antibiotics at the time of registration* Hepatic insufficiency resulting in clinical jaundice and/or coagulation defects* Chronic obstructive pulmonary disease exacerbation or other respiratory illness requiring hospitalization or precluding study therapy at the time of registration* Uncontrolled, clinically significant cardiac arrhythmias* Human immunodeficiency virus (HIV) positive with cluster of differentiation (CD)4 count < 200 cells/microliter** Note: patients who are HIV positive are eligible, provided they are under treatment with highly active antiretroviral therapy (HAART) and have a CD4 count >= 200 cells/microliter within 30 days prior to Step 1 registration** Note: HIV testing is not required for eligibility for this protocol
302.0
Human immunodeficiency virus (HIV) infected patients are eligible provided they meet all the other eligibility criteria of the study in addition to the following: * No history of acquired immune deficiency syndrome (AIDS)-defining conditions other than lymphoma or history of CD4+ T-cells below 200/mm^3 prior to beginning combination antiretroviral therapy (cART)* After HIV diagnosis and during treatment with cART, patients should have maintained CD4+ T-cells >= 350/mm^3 prior to lymphoma diagnosis; patients who never immune reconstituted to a stable level above 350/mm^3 are not eligible* At time of study entry CD4+ T-cells must have recovered from prior lymphoma therapy to >= 250/mm^3* At the time of study entry the HIV viral load must be undetectable by standard laboratory assay * During prior lymphoma therapy, patients must not have experienced documented infections attributed to the HIV+ status* No history of non-adherence to cART and willing to adhere to cART while on study* Antiretroviral drugs with overlapping or similar toxicity profiles as study agents not allowed:** Efavirenz not allowed** Stavudine not allowed** Zidovudine not allowed* Patients must be willing to be followed at a minimum of approximately every 3 months by physician expert in HIV disease management
36.0
Human immunodeficiency virus (HIV)-positive patients with well-controlled disease, as determined by CD4 count and viral load, who are on antiretroviral therapy that does not contain a strong inducer or inhibitor of CYP3A4 are allowed on trial; HIV-positive patients on combination antiretroviral therapy with strong inducers or inhibitors of CYP3A4 are ineligible; patients with poorly controlled HIV are not eligible
45.0
Human immunodeficiency virus (HIV)+ patients are eligible for the trial provided they meet the other study criteria in addition to the following:* CD4+ T-cells >= 250/mm^3* HIV sensitive to antiretroviral therapy* Zidovudine not allowed* Long term survival anticipated on the basis of HIV alone were it not for the lymphoma* No concurrent acquired immunodeficiency syndrome (AIDS)-defining illness other than the lymphoma
50.0
Human immunodeficiency virus (HIV)-positive patients on combination antiretroviral therapy are eligible; unless the patient�s cluster of differentiation (CD)4+ count is below the institutional lower limit of normal
32.0
Healthy human immunodeficiency virus (HIV)-infected patients are eligible, provided that they meet all the other study criteria in addition to the following (HIV testing is not required for study enrollment):* CD4+ cell count >= 250/mm^3* HIV viral loads undetectable by standard clinical tests
64.0
Human immunodeficiency virus (HIV)-positive patients with well-controlled disease, as determined by CD4 count and viral load, who are on antiretroviral therapy that does not contain a strong inducer or inhibitor of CYP3A4 (e.g. regimens containing ritonavir, cobicistat, efavirenz or etravirine) are allowed on trial; HIV-positive patients on combination antiretroviral therapy with strong inducers or inhibitors of CYP3A4 are ineligible; patients with poorly controlled HIV are not eligible
51.0
Patients with a known history of human immunodeficiency virus (HIV) are eligible, if they meet all of the following conditions:* No history of HIV complications with the exception of cluster of differentiation (CD)4 count < 200 cells/mm^3* No antiretroviral therapy with overlapping toxicity such as myelosuppression* HIV viral loads below the limit of detection* No history of highly active antiretroviral therapy (HAART)-resistant HIV
56.0
Patients with acquired immunodeficiency syndrome (AIDS-related illnesses) or known human immunodeficiency virus (HIV) disease must:* Have a cluster of differentiation (CD)4 count >= 200 cells/uL within 30 days before beginning study therapy* Be off all antiretroviral therapy (prophylaxis/treatment) more than 60 days before beginning study therapy, and* Have no evidence of opportunistic infections
348.0
Patients known to be human immunodeficiency virus (HIV) positive are eligible if they meet the following criteria within 30 days prior to registration: stable and adequate CD4 counts (>= 350 mm^3), and serum HIV viral load of < 25,000 IU/ml; patients must be on a stable anti-viral therapy
77.0
Human immunodeficiency virus (HIV)-positive patients are eligible provided the following criteria are met: CD4 count > 350/mm^3, an undetectable viral load, and not receiving prophylaxis antibiotics
38.0
Known human immunodeficiency virus (HIV) positive with CD4 count < 200 cells/microliter. Note that patients who are HIV positive are eligible, provided they are under treatment with highly active antiretroviral therapy (HAART) and have a CD4 count >= 200 cells/microliter within 30 days prior to registration; note also that HIV testing is not required for eligibility for this protocol; this exclusion criterion is necessary because the treatments involved in this protocol may be significantly immunosuppressive.
186.0
Human immunodeficiency virus (HIV) positive with cluster of differentiation 4 (CD4) count < 200 cells/microliter; note that patients who are HIV positive are eligible, provided they are under treatment with highly active antiretroviral therapy (HAART) and have a CD4 count >= 200 cells/microliter within 30 days prior to step 1 registration; note also that HIV testing is not required for eligibility for this protocol
612.0
Patients who are known to be human immunodeficiency virus (HIV)-positive at registration are eligible at the time of registration:1. Cluster of differentiation (CD)4+ cell count greater or equal to 250 cells/mm^32. If patient is on antiretroviral therapy, there must be minimal interactions or overlapping toxicity of the antiretroviral therapy with the experimental cancer treatment; once daily combinations that use pharmacologic boosters may not be used3. No history of non-malignancy acquired immunodeficiency syndrome (AIDS)-defining conditions other than historical low CD4+ cell counts
707.0
Patients with a known history of testing positive for human immunodeficiency virus (HIV) or known acquired immunodeficiency syndrome (AIDS) will be eligible if:* They are generally healthy from an HIV perspective and on a stable anti-retroviral regimen for > 6 months* They have had no AIDS-defining conditions in the past 12 months other than historically low CD4+ cell counts* They have an undetectable viral load on standard assays
30.0
Human immunodeficiency virus (HIV) positive patients are not excluded, but to enroll, must meet all of the below criteria:* HIV is sensitive to antiretroviral therapy* Must be willing to take effective antiretroviral therapy that has minimal overlapping toxicity and pharmacokinetic interactions with protocol therapy* No history of HIV-related opportunistic disease or acquired immune deficiency syndrome (AIDS)-defining conditions within past 12 months other than historic CD4+ T-cell counts below 200 cells/mm^3* Expected long-term survival if lymphoma were not present
689.0
Major medical illnesses or psychiatric impairments, which in the investigators opinion, will prevent administration or completion of the protocol therapy and/or preclude informed consent; these include, but are not restricted to:* Unstable angina and/or congestive heart failure requiring hospitalization at the time of step 2 registration* Transmural myocardial infarction within the last 6 months prior to step 2 registration* Acute bacterial or fungal infection requiring intravenous antibiotics at the time of step 2 registration* Chronic obstructive pulmonary disease exacerbation or other respiratory illness requiring hospitalization or precluding study therapy at the time of step 2 registration* Type II neurofibromatosis (NF2)* Ailments entailing substantial increases in sensitivity and side effect risk from radiation therapy (ataxia telangiectasia, Nijmegen breakage syndrome, and human immunodeficiency virus (HIV) with CD4 count < 200 cells/microliter); HIV testing is not required for eligibility for this protocol, and known HIV positive patients are eligible, provided they are under treatment with highly active antiretroviral therapy (HAART) and have a CD4 count >= 200 cells/microliter within 30 days prior to step 2 registration* Inability to undergo MRI with and without contrast (e.g. claustrophobia, non-MRI compatible implant or foreign body, etc) or receive gadolinium; note that patients with severe claustrophobia are permitted on this study if they are willing and able to undergo MRI with adequate sedation or anesthesia
148.0
Severe, active co-morbidity, defined as follows:* Unstable angina and/or congestive heart failure requiring hospitalization within the last 6 months* Transmural myocardial infarction within the last 6 months* Acute bacterial or fungal infection requiring intravenous antibiotics at the time of step 1 registration* Chronic obstructive pulmonary disease exacerbation or other respiratory illness requiring hospitalization or precluding study therapy at the time of step 1 registration* Severe hepatic disease, defined as a diagnosis of Child-Pugh class B or C hepatic disease* Human immunodeficiency virus (HIV) positive with cluster of differentiation (CD)4 count < 200 cells/microliter; note that patients who are HIV positive are eligible, provided they are under treatment with highly active antiretroviral therapy (HAART) and have a CD4 count >= 200 cells/microliter within 30 days prior to registration; note also that HIV testing is not required for eligibility for this protocol* End-stage renal disease (ie, on dialysis or dialysis has been recommended)
282.0
Human immunodeficiency virus (HIV) positive (+) patients with CD4 counts >= 250 cells/mm^3 on anti-viral therapy are eligible for the study
47.0
HIV positive with CD4 count < 200 cells/microliter; note that patients who are human immunodeficiency virus (HIV) positive are eligible, provided they are under treatment with highly active antiretroviral therapy (HAART) and have a CD4 count >= 200 cells/microliter prior to registration; note also that HIV testing is not required for eligibility for this protocol
186.0
Patients with hepatitis B virus infection must have undetectable hepatitis B virus (HBV) on suppressive therapy and no evidence of HBV-related hepatic damage; patients with hepatitis C virus infection are eligible if complete eradication therapy has been successfully completed, and there is no detectable hepatitis C virus (HVC) or related hepatic damage; patients with known human immunodeficiency virus (HIV) infection are eligible if they meet all of the following criteria:* Patient must have no history of acquired immune deficiency syndrome (AIDS)-related complications, other than a history of low CD4+ T-cell count (< 200/mm3) prior to initiation of combination antiretroviral therapy; on study CD4+ T-cell count may not be informative due to leukemia and should not be used as an exclusion criterion if low* Patient must be healthy on the basis of HIV disease with high likelihood of near normal life span were it not for the leukemia* Patient must have serum HIV viral load of < 200 copies/mm^3* Patient must be on combination antiretroviral therapy with minimal pharmacokinetic interactions with study therapy and minimal overlapping clinical toxicity with protocol therapy; (recommend a regimen of the integrase inhibitor dolutegravir combined with either disoproxil fumarate/emtricitabine or dolutegravir combined with tenofovir alafenamide/emtricitabine)* Protease inhibitors and once daily formulations containing cobicistat are NOT allowed* Stavudine and zidovudine (AZT) are NOT allowed
150.0