Aspartate aminotransferase (AST) or alanine aminotransferase (ALT) < 3 x institutional ULN 700.0 Aspartate aminotransferase (AST), alanine aminotransferase (ALT) =< grade 1 747.0 Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< 10 x ULN 276.0 Patients must have aspartate aminotransferase (AST)/alanine aminotransferase (ALT) =< 5 x IULN, unless due to lymphoma, within 42 days prior to registration 155.0 Aspartate aminotransferase (AST)/alanine aminotransferase (ALT) < 2.5 times the institutional ULN (unless elevated secondary to lymphomatous involvement of the liver, in which case the AST/ALT must be =< 5 times the institutional ULN) 90.0 Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< 3.0 x ULN 52.0 Obtained =< 7 days prior to registration: Aspartate aminotransferase (AST) or alanine aminotransferase (ALT) =< 3 x institutional ULN 102.0 Serum alanine aminotransferase (ALT), aspartate aminotransferase (AST) > 2.5 x ULN 45.0 Aspartate aminotransferase (AST) or alanine aminotransferase (ALT) < 3 x the institutional ULN 252.0 Aspartate aminotransferase (AST) or alanine aminotransferase (ALT) < 3 x institutional ULN within 14 days prior to registration 660.0 Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< 2.5 x ULN 80.0 Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< 2.5 x IULN (or < 5 x IULN for patients with known liver metastases) 97.0 Serum alanine aminotransferase (ALT) < 2.5 x ULN 2060.0 Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< 2.5 x institutional ULN 30.0 Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< 2.5 x institutional ULN 40.0 Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< 2.5 x institutional ULN, within 2 weeks of the first dose of study treatment 18.0 Aspartate aminotransferase level (AST) =< 3 x ULN, within 30 days prior to enrollment 278.0 Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) less than or equal to 3 x ULN 540.0 Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< 2.5 x institutional ULN 130.0 Alanine aminotransferase (ALT) =< 3 x ULN within 14 days prior to study registration 440.0 Aspartate aminotransferase (AST) =< 3 x ULN within 14 days prior to study registration 440.0 Either alanine aminotransferase (ALT) or aspartate aminotransferase (AST) =< 2 x IULN within 28 days prior to sub-study registration (if both ALT and AST are done, both must be =< 2 IULN); for patients with liver metastases, either ALT or AST must be =< 5 x IULN (if both ALT and AST are done, both must be =< 5 x IULN) 10000.0 Aspartate aminotransferase (AST) or alanine aminotransferase (ALT) =< 1.5 x institutional ULN, within 21 days prior to registration 924.0 Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) =< 3 x ULN 606.0 Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< 2.5 x institutional ULN 35.0 Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< 2.5 x IULN (or < 5 x IULN for patients with known liver metastases) 280.0 Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< 3 x ULN (=< 5 x ULN for patients with documented liver metastases) 300.0 Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< 2.5 x institutional ULN 18.0 Obtained within 28 days prior to registration: Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< 2.5 x IULN (or =< 5 x IULN for patients with known liver metastases) 223.0 Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) =< 3 x ULN 96.0 Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< 3 x ULN (=< 5 x ULN for patients with documented liver metastases) 400.0 Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) < 2.5 x ULN (values post biliary stenting allowed for eligibility) 23.0 Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) both =< 2.5 x IULN 150.0 Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< 2.5 x ULN 64.0 Within 14 days prior to registration: Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< 2.5 x IULN; patients with liver metastases may have AST and ALT of =< 5.0 x IULN 143.0 CLINICAL/LABORATORY CRITERIA: Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< 2.5 x IULN (or =< 5 x IULN for patients with known liver metastases); these results must be obtained within 28 days prior to registration 53.0 Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) =< 3 x ULN, within 14 days prior to registration 147.0 Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) =< 3 x ULN 84.0 Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< 2.5 x ULN, within 4 weeks of randomization 766.0 Obtained within 28 days prior to registration: Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< 2.5 x IULN (or < 5 x IULN for patients with known liver metastases) 77.0 Alanine aminotransferase (ALT) =< 3.0 X ULN 24.0 Within 28 days prior to registration: Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) both =< 3 x IULN 707.0 Within 14 days prior to registration: Aspartate aminotransferase (AST)/alanine aminotransferase (ALT) =< 3 x ULN (AST and/or ALT =< 5 x ULN for patients with liver involvement) 488.0 Aspartate aminotransferase (AST) or alanine aminotransferase (ALT) =< 2 x IULN 148.0 Within less than or equal to 14 days prior to registration: Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) =< 2.5 x ULN 40.0 Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< 2.5 x institutional ULN 40.0 Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) both < 2.5 x IULN within 28 days prior to registration 64.0 Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< 2.5 x institutional ULN 68.0 Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< 2.5 x institutional ULN 21.0 Transaminases (aspartate aminotransferase [AST] and alanine aminotransferase [ALT]) < 6 x institutional ULN 186.0 Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< 2.5 x IULN (=< 5 x IULN secondary to lymphoma) within 28 days prior to registration 150.0 Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) both =< 5 x IULN within 28 days prior to registration 94.0 Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) =< 3 x ULN 120.0 Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< 2.5 x institutional ULN within 30 days of day 1 of study 27.0 Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< 2.5 x upper limit of normal (ULN); if liver metastases are present, =< 5 x ULN 36.0 TREATMNET: Aspartate aminotransferase (AST) =< 3 x upper limit of normal 44.0 Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< 3.0 times institutional upper limit of normal with or without liver metastasis, within 21 days prior to study entry 143.0 Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) =< 1.5 x institutional upper limit of normal (IULN) within 28 days prior to registration 1900.0 Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) < 6 times upper limit of normal (ULN); obtained within 14 days prior to study entry 368.0 Aspartate aminotransferase (AST)/alanine aminotransferase (ALT) =< 2.5 x upper limit of normal (ULN) within 14 days prior to registration 234.0 Aspartate aminotransferase (AST)/alanine aminotransferase (ALT) =< 2.5 x upper limit of normal (ULN) obtained within 2 weeks prior to registration 189.0 Aspartate aminotransferase (AST)/alanine aminotransferase (ALT) within =< 3 x upper limit of normal 104.0 Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) < 2.5 x the upper limit of normal 52.0 Alanine aminotransferase (ALT) =< 2.5 x the upper limit of institutional normal 52.0 Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) < 2.5 x upper limits of normal (ULN) 97.0 Alanine aminotransferase level (ALT) =< 3 x the upper limit of normal (ULN), within 30 days prior to enrollment 278.0 Obtained =< 48 hours prior to registration: Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) < 3 x upper limit of normal (ULN) 509.0 Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) =< 2.5 times upper limit of normal 250.0 Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) < 3 x the institutional upper limit of normal 28.0 Aspartate aminotransferase (AST) =< 2.5 x upper limit of normal (ULN) 20.0 If liver metastases present, aspartate aminotransferase (AST) and alanine aminotransferase (ALT) must be < 3 x upper limit of normal (ULN) 84.0 Transaminases (alanine aminotransferase [ALT], aspartate aminotransferase [AST]) =< 2.5 x institutional upper limit normal 600.0 Liver transaminases (alanine aminotransferase [ALT], aspartate aminotransferase [AST]) greater than 3 times the upper limit of normal 125.0 Patients must have aspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< 3.0 x institutional upper limit of normal (IULN) within 14 days prior to registration 44.0 Serum aspartate aminotransferase (AST) and serum alanine aminotransferase (ALT) =< 2.5 x upper limit of normal (ULN) NONE Aspartate aminotransferase (AST)/alanine aminotransferase (ALT) =< 2.5 upper limits of normal (ULN)* Unless due to hepatic metastases in which case levels =< 5 x ULN are allowed 420.0 Within 14 days of registration: Aspartate aminotransferase (AST) =< 2.5 x upper limits of normal (ULN) 110.0 Aspartate aminotransferase (AST)/alanine aminotransferase (ALT) =< 2.5 x upper limit of normal (ULN) 69.0 Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< 3 x upper limit of normal (ULN) 302.0 Aspartate aminotransferase (AST) or alanine aminotransferase (ALT) =< 3.0 x upper limits of normal (ULN) 130.0 Aspartate aminotransferase (AST)/alanine aminotransferase (ALT) =< 3.0 upper limit of normal (ULN) 45.0 Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) =< 2.5 x institutional upper limit of normal (IULN) (or =< 5 x IULN if liver metastases are present) 333.0 Aspartate aminotransferase (AST)/alanine aminotransferase (ALT) =< 3 x upper limit of normal (ULN); if liver metastases, =< 5 x upper limit of normal (ULN) 137.0 Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) < 3 x the upper limit of normal 24.0 Serum aspartate aminotransferase (AST) and/or alanine aminotransferase (ALT) > 3 times upper limit of institutional normal 250.0 Aspartate aminotransferase (AST) / alanine aminotransferase (ALT) =< 2.5 X upper limit of normal (ULN) 124.0 Aspartate aminotransferase (AST) or alanine aminotransferase (ALT) < 1.5 x the upper limit of normal 612.0 Aspartate aminotransferase (AST)/alanine aminotransferase (ALT) =< 2.5 x upper limit of normal (ULN) 700.0 Aspartate aminotransferase (AST), alanine aminotransferase (ALT) =< 3 x upper limit of normal (ULN), unless suspected leukemic involvement of the liver 324.0 Within 6 weeks prior to randomization: Aspartate aminotransferase (AST) must be =< 1.5 x ULN for the lab* Note: If alanine aminotransferase (ALT) is performed instead of AST (per institution's standard practice), the ALT value must be =< 1.5 x ULN; if both were performed, the AST must be =< 1.5 x ULN 990.0 Re-registration: AST/ALT =< 3 x ULN 195.0 Aspartate aminotransferase (AST) must be =< 3 x ULN for the lab within 28 days before randomization;* Note: if alanine aminotransferase (ALT) is performed instead of AST (per institution's standard practice), the ALT value must be =< 3 x ULN; if both were performed, the AST must also be =< 3 x ULN; if AST and/or ALT is >= ULN but =< 3 x ULN, serologic testing for hepatitis B and C must be performed and results for viral infection must be negative 348.0