Absolute neutrophil count >= 1,500/mm^3 130.0 Absolute neutrophil count >= 1,500/mm^3 110.0 Absolute neutrophil count: >= 750/mm^3 62.0 Absolute neutrophil count < 1.5 x 10^9/L 45.0 Absolute neutrophil count >= 1.5 x 10^9/L 72.0 Absolute neutrophil count >= 1,500/mm^3 52.0 Absolute neutrophil count >= 1 x 10^9/L 68.0 Neutrophil count >= 1.5 x 10^9/L 250.0 Absolute neutrophil count: >= 750/mm^3 within 90 days before enrollment 5058.0 Absolute neutrophil count >= 1,000/mm^3 40.0 Absolute neutrophil count: >= 1,500/mm^3 56.0 Absolute neutrophil count >= 1,500/mm^3 126.0 Absolute neutrophil count >= 1,500/microliters 37.0 Absolute neutrophil count >= 1,500/mm^3 within 4 weeks prior to randomization 345.0 Absolute neutrophil count >= 1,500/mm^3 36.0 Absolute neutrophil count >= 1,500/mm^3 24.0 Absolute neutrophil count >= 1.0 x 10^9/L 25.0 Absolute neutrophil count >= 1500 cells/mm^3 612.0 Absolute neutrophil count < 1.5 x 10^9/L 98.0 Absolute neutrophil count >= 1500/mcL 102.0 Absolute neutrophil count >= 1,500/mcL 276.0 Absolute neutrophil count >= 1,000/mcL assessed within seven (7) days prior to the start of therapy 30.0 Absolute neutrophil count >= 1,500/mcl 162.0 REGISTRATION #2 - PRIOR TO CONSOLIDATION CHEMOTHERAPY: Absolute neutrophil count >= 1,500 mcl 162.0 Absolute neutrophil count >= 1,500/mcL 40.0 Absolute neutrophil count >= 1,500/mcL 107.0 Obtained within 30 days of registration: Absolute neutrophil count >= 1,500/mcL 24.0 Absolute neutrophil count >= 1,500/mcL 55.0 Absolute neutrophil count >= 1,500/mcL 165.0 Absolute neutrophil count >= 1,500/mcL 42.0 Absolute neutrophil count >= 1,500/mcL 36.0 Absolute neutrophil count >= 1,500/mcL 140.0 Absolute neutrophil count >= 1,500/mcL 68.0 Absolute neutrophil count >= 1,500/mcL 42.0 Absolute neutrophil count >= 1,500/mcL 73.0 Absolute neutrophil count >= 1,500/mcL 80.0 Absolute neutrophil count >= 1,500/mcL 70.0 Absolute neutrophil count >= 1,500/mcL 72.0 TUMOR BIOPSY SEQUENCING: Absolute neutrophil count >= 1,000/uL (mcL) 700.0 TREATMENT: Absolute neutrophil count >= 1,000/uL (mcL) 700.0 Absolute lymphocytes count >= 500/mcL 12.0 Absolute neutrophil count >= 1,000/mcL (without hematopoietic growth factors) 12.0 Absolute neutrophil count >= 1,500/mcL 54.0 Absolute neutrophil count >= 1,200/mcL 32.0 Absolute neutrophil count >= 1,500/mcL 100.0 Absolute neutrophil count >= 1,500/mcL 24.0 Absolute neutrophil count >= 1,500/mcL 600.0 Absolute neutrophil count >= 1,500/mcL 35.0 Absolute neutrophil count >= 1,500/mcL 40.0 Absolute neutrophil count >= 1,500/mcL (patients may be treated with hematopoietic growth factors to achieve or maintain this level) 44.0 Absolute neutrophil count >= 1,500/mcL 57.0 Absolute neutrophil count >= 750 cells/mcL (0.75 x 10^9/L) 52.0 Absolute neutrophil count >= 1,500/mcL 90.0 Lymphocyte count > 1,000/mcL 90.0 Absolute neutrophil count >= 1,500/mcL 36.0 Absolute neutrophil count >= 1,500/mcL 23.0 Absolute neutrophil count >= 1,000/mcL 80.0 Absolute neutrophil count >= 1,200/mcL 135.0 Absolute neutrophil count >= 1,500/mcL 37.0 Absolute neutrophil count >= 1,500/mcL 66.0 Absolute neutrophil count >= 1,500/mcL 12.0 Absolute neutrophil count >= 1,500/mcL** Participants may be receiving growth factor support to meet these criteria 42.0 Absolute neutrophil count >= 1,500/mcL 209.0 Absolute neutrophil count >= 1,500/mcL 30.0 Absolute neutrophil count >= 1,500/mcL 75.0 Absolute neutrophil count >= 1,500/mcL 50.0 Absolute neutrophil count >= 1,500/mcL 30.0 Absolute neutrophil count >= 1,500/mcL 549.0 Absolute neutrophil count >= 1,500/mcL 680.0 Absolute neutrophil count >= 1,500/mcL 46.0 Absolute neutrophil count >= 1,500/mcL 45.0 Absolute neutrophil count >= 1,500/mcL 82.0 Absolute neutrophil count >= 1,500/mcL 126.0 Absolute neutrophil count >= 1,500/mcL 50.0 Absolute neutrophil count >= 1,500/mcL 46.0 Absolute neutrophil count >= 1,500/mcL 15.0 Absolute neutrophil count >= 1,500/mcL 46.0 Absolute neutrophil count > 1000/mcL 36.0 Absolute neutrophil count >= 1,500/mcL 90.0 Absolute neutrophil count >= 1,500/mcL 45.0 Absolute neutrophil count >= 1,000/mcL 50.0 Absolute neutrophil count > 500/mcL 60.0 Within 2 weeks prior to initiation of study treatment: Absolute neutrophil count >= 1,500/mcL 70.0 Absolute neutrophil count >= 1,500/mcL 51.0 Absolute neutrophil count >= 1,500/mcL without the use of hematopoietic growth factors 48.0 Absolute neutrophil count >= 1,500/mcL 20.0 Absolute neutrophil count >= 1,500/mcL 60.0 Absolute neutrophil count >= 1,500/mcL 38.0 Absolute neutrophil count >= 1,500/mcL 70.0 Absolute neutrophil count >= 1,000/mcL 24.0 Absolute neutrophil count >= 1,500/mcL 35.0 Absolute neutrophil count >= 1,500/mcL 24.0 Absolute neutrophil count >= 1,000/mcL 28.0 Absolute neutrophil count >= 1,500/mcL 72.0 Absolute neutrophil count >= 1,000/mcL 40.0 Absolute neutrophil count >= 1,500/mcL 60.0 Absolute neutrophil count >= 1,500/mcL 180.0 Within 28 days prior to administration of study treatment: Absolute neutrophil count >= 1,500/mcL 90.0 Within 28 days prior to administration of therapy: Absolute neutrophil count >= 1,500/mcL 132.0 Absolute neutrophil count >= 1,500/mcL 40.0 Absolute neutrophil count >= 1,500/mcL 22.0 Absolute neutrophil count >= 1,500/mcL 70.0 Absolute neutrophil count >= 1,000/mcL 47.0 Absolute neutrophil count >= 1,500/mcL 35.0 Absolute neutrophil count >= 1,500/mcL 78.0 Leukocytes >= 3,000/mcL 40.0 Obtained within 30 days of registration: Leukocytes >= 3,000/mcL 24.0 Leukocytes >= 3,000/mm^3 110.0 Leukocytes >= 3,000/mcL 55.0 Leukocytes >= 3,000/mcL 42.0 Leukocytes >= 3,000/mcL 80.0 Leukocytes >= 3,000/mcL 70.0 Leukocytes >= 3,000/mcL 72.0 Leukocytes >= 3,000/mcL 12.0 Leukocytes >= 3,000/mcL 68.0 Leukocytes >= 3,000/mcL 130.0 Leukocytes >= 3,000/mcL 32.0 Leukocytes >= 3,000/mcL 100.0 Leukocytes >= 3,000/mcL 44.0 Leukocytes >= 3,000/mcL 57.0 Leukocytes >= 2,000/mcL 36.0 Leukocytes: >= 3,000/mm^3 56.0 Leukocytes >= 1,500/mcL 80.0 Leukocytes >= 3,000/mcL 135.0 Leukocytes >= 3,000/mcL 12.0 Leukocytes >= 3,000/mcL 209.0 Leukocytes >= 3,000/uL 35.0 Leukocytes >= 3,000/mcL 30.0 Leukocytes >= 3,000/mcL 30.0 Leukocytes >= 3,000/mm^3 126.0 Leukocytes >= 3,000/mcL 45.0 Leukocytes >= 2,000/uL 33.0 Leukocytes >= 3,000/mcL 126.0 Leukocytes >= 3,000/mcL 50.0 Leukocytes >= 3,000/mcL 46.0 Leukocytes >= 3,000/mcL 15.0 Leukocytes >= 3,000/mcL 46.0 Leukocytes >= 3,000/mcL 90.0 Leukocytes >= 3,000/mcL 45.0 Leukocytes >= 3,000/mcL 46.0 Leukocytes no lower limit 60.0 Within 2 weeks prior to initiation of study treatment: Leukocytes >= 3,000/mcL 70.0 Leukocytes >= 2,500/mcL 29.0 Leukocytes >= 3,000/mcL 51.0 Leukocytes >= 3,000/mcL 150.0 Leukocytes >= 3,000/mcL 48.0 Leukocytes >= 3,000/mcL 20.0 Leukocytes >= 3,000/mm^3 36.0 Leukocytes >= 3,000/mcL 38.0 Leukocytes >= 2,500/mcL 35.0 Leukocytes >= 3,000/mcL 72.0 Leukocytes >= 2,500/mcL 60.0 Within less than or equal to 14 days prior to registration: Leukocytes >= 3,000/mm^3 40.0 Leukocytes >= 3,000/mcL 40.0 Leukocytes >= 3,000/mcL 70.0 Leukocytes >= 3,000/mcL 47.0 Leukocytes >= 2,500/mcL 78.0 Granulocytes >= 1,500/ul 729.0 Absolute granulocytes >= 1500 cells/uL (1.5 x 10^9 L) 90.0 Granulocytes >= 1,500/ul 450.0 Granulocytes (ANC) >= 1,500/mcl 50.0 Peripheral absolute neutrophil count (ANC) >= 1000/mm^3 77.0 Peripheral absolute neutrophil count (ANC) >= 750/mm^3 484.0 * Peripheral absolute neutrophil count (ANC) >= 1000/mm^3 81.0 Peripheral absolute neutrophil count (ANC) >= 1000/mm^3 67.0 Peripheral absolute neutrophil count (ANC) >= 1000/mm^3 36.0 Absolute neutrophil count (ANC) >= 1,000/uL 400.0 Absolute neutrophil count (ANC) > 750/uL 253.0 Absolute neutrophil count (ANC) >= 1000/uL 100.0 Absolute neutrophil count (ANC) >= 1,500/uL 74.0 Absolute neutrophil count (ANC) >= 1.5 x 10^9/L 132.0 Peripheral absolute neutrophil count (ANC) >= 1,000/uL 275.0 Peripheral absolute neutrophil count (ANC) >= 750/uL 74.0 Absolute neutrophil count >= 1,000/uL (unsupported), within 14 days of registration and within 7 days of the start of treatment 180.0 Absolute neutrophil count (ANC) >= 1000/uL 70.0 Absolute neutrophil count (ANC) >= 1500/uL 80.0 Absolute neutrophil count (ANC) >= 1,200/ul 97.0 Absolute neutrophil count (ANC) >= 1.5 x 10^9/L 30.0 Absolute neutrophil count >= 1,500/uL 72.0 Absolute neutrophil count >= 1500/ul 104.0 Absolute neutrophil count (ANC) >= 1000/ul (unsupported) 52.0 Absolute neutrophil count (ANC) >= 1.0 x 10^9/L 97.0 Absolute neutrophil count (ANC) >= 1.2 x 10^9/L 40.0 Absolute neutrophil count (ANC) >= 1.2 x 10^9/L, within 2 weeks of the first dose of study treatment 18.0 Absolute neutrophil count (ANC) >= 1500/uL 92.0 Absolute neutrophil count (ANC) >= 1.2 x 10^9/L 68.0 Absolute neutrophil count (ANC) >= 1000/uL 28.0 Absolute neutrophil count (ANC) >= 1.5 x 10^9/L 35.0 Absolute neutrophil count >= 1,500/uL 23.0 Absolute neutrophil count >= 1500/uL; Note: no transfusions are permitted 7 days prior to laboratory studies to determine eligibility 340.0 Absolute neutrophil count (ANC) >= 1,200/ul 280.0 Absolute neutrophil count (ANC) >= 1,500/uL, obtained within 4 weeks prior to randomization 300.0 Absolute neutrophil count (ANC) >= 1.2 x 10^9/L 18.0 Absolute neutrophil count (ANC) >= 1,500/ul 96.0 Absolute neutrophil count (ANC) >= 1,500/uL 400.0 Absolute neutrophil count >= 1,500/uL 58.0 Absolute neutrophil count >= 1000 cells/uL 110.0 INCLUSION CRITERIA FOR STRATUM C: Absolute neutrophil count >= 1000 cells/uL 110.0 Absolute neutrophil count >= 1,500/uL 35.0 Absolute neutrophil count (ANC) >= 1,500 23.0 Absolute neutrophil count > 1,500/uL 188.0 Absolute neutrophil count >= 1,500/uL 33.0 Absolute neutrophil count (ANC) >= 1.5 x 10^9/L 36.0 Peripheral absolute neutrophil count (ANC) >= 750/uL 337.0 Absolute neutrophil count (ANC) > 1,500/uL 32.0 Absolute neutrophil count (ANC) >= 1.5 x 10^9/L 64.0 Peripheral absolute neutrophil count (ANC) >= 1000/uL 45.0 Absolute neutrophil count (ANC) >= 1500/uL 40.0 Absolute lymphocyte count (ALC) >= 800/uL 40.0 Absolute neutrophil count (ANC) >= 1.2 x 10^9/L 68.0 Absolute neutrophil count (ANC) >= 1.5 x 10^9 /L 21.0 Absolute neutrophil count >= 1,500/uL 30.0 Absolute neutrophil count (ANC) >= 1,500/mcL 36.0 Absolute neutrophil count (ANC) >= 1,500/mcl 360.0 Absolute neutrophil count (ANC) >= 1,000 cells/mcL within 42 days prior to registration 155.0 Absolute neutrophil count (ANC) >= 1,500/mcl 52.0 Absolute neutrophil count (ANC) >= 1,500/mL within 28 days prior to registration 1900.0 Absolute neutrophil count (ANC) >= 1500/mcL (1.5 x 10^9/L) obtained within 2 weeks prior to registration 189.0 RE-REGISTRATION ELIGIBILITY CRITERIA (STEP 2): Absolute neutrophil count (ANC) >= 1.0 x 10^9/L 97.0 Absolute neutrophil count (ANC) greater than or equal to 1,500/mcl 540.0 Absolute neutrophil count (ANC) >= 1,200/mcL (subjects may be treated with hematopoietic growth factors to achieve or maintain this level) 130.0 Absolute neutrophil count (ANC) >= 1,500/mcl obtained within 28 days prior to sub-study registration 10000.0 Absolute neutrophil count (ANC) >= 1.5 x 10^9/L measured within 28 days prior to randomization 1500.0 Absolute neutrophil count (ANC) >= 1,500/mcL 230.0 Absolute neutrophil count (ANC) >= 750/mcl within 28 days prior to registration 44.0 Obtained within 28 days prior to registration: Absolute neutrophil count (ANC) >= 1,500/mcL 223.0 Absolute neutrophil count (ANC) >= 1,500/mcL 150.0 Absolute neutrophil count (ANC) >= 1,000/mcL; must be obtained within 28 days prior to registration 180.0 Absolute neutrophil count (ANC) >= 1,500/mcL 46.0 Absolute neutrophil count (ANC) of >= 1,500/mL within 21 days prior to registration 333.0 Absolute neutrophil count (ANC) >= 1,500/mcL 150.0 Within 14 days prior to registration: Absolute neutrophil count (ANC) >= 1,500/mcL 143.0 CLINICAL/LABORATORY CRITERIA: Absolute neutrophil count (ANC) >= 1500/mcL; these results must be obtained within 28 days prior to registration 53.0 Absolute neutrophil count (ANC) greater than or equal to 1,500/mcl, within 14 days prior to registration; this ANC cannot have been induced by granulocyte colony stimulating factors 147.0 Absolute neutrophil count (ANC) >= 1,500/mcl 84.0 Obtained within 28 days prior to registration: Absolute neutrophil count (ANC) >= 1,500/mcl 77.0 Absolute neutrophil count (ANC) >= 1.5 x 10^9/L within 14 days prior to registration. 186.0 Within 28 days prior to registration: ANC >= 1,000/mcL 707.0 Within 14 days prior to registration: Absolute neutrophil count (ANC) >= 1,500/mcl 488.0 Absolute neutrophil count (ANC) >= 1,500 microliter (mcL) 148.0 Within less than or equal to 14 days prior to registration: Absolute neutrophil count (ANC) >= 1.5 x 10^9/L 40.0 Absolute neutrophil count (ANC) >= 1,500 microliter (mcL), obtained within 28 days prior to step 2 registration 1000.0 Absolute neutrophil count (ANC) >= 1,500/mcL within 28 days prior to registration 64.0 Absolute neutrophil count (ANC) >= 1,500/mcL within 28 days prior to registration 150.0 Absolute neutrophil count (ANC) >= 1,500/mcL within 28 days prior to registration 94.0 Absolute neutrophil count (ANC) >= 1 x 10^9/L within 30 days of day 1 of study 27.0 White blood cell count >= 4000 cells/mm^3 285.0 White blood cell count (WBC) >= 4,000/ml 37.0 B-ALL patients must have an initial white blood cell count < 50,000/uL 9483.0 White blood cell (WBC) > 3.0 224.0 White blood cells (WBC) >= 3,000 cells/uL (3.0 x 10^9 L) or 90.0 Total white blood cells (WBC) >= 4.0 x 10^3/mcL within 28 days prior to registration 491.0 White blood cells (WBC) >= 3500/uL 92.0 White blood count >= 3,000/uL, obtained within 4 weeks prior to randomization 300.0 White blood count >= 3,000/uL 400.0 Patients with white blood cell (WBC) > 30,000 are not eligible to start therapy; however, it is permissible to use glucocorticoids and/or hydroxyurea to diminish peripheral WBC to less than 30,000 provided these agents are stopped at least 24 hours prior to the first dose of MLN0128 (TAK-228) 35.0 Total absolute phagocyte count (APC = [%neutrophils + %monocytes) x white blood cells [WBC]) is at least 1000/uL 44.0 White blood cell count (WBC) >= 2,000/mcL; must be obtained within 28 days prior to registration 180.0 White blood cell (WBC) >= 2000/uL 714.0 White blood cells >= 2000/uL, within 4 weeks of randomization 766.0 Within 28 days prior to administration of study treatment: White blood count (WBC) > 3 x 10^9/L 90.0 White blood cell count (WBC) >= 3 x 10^9/L 132.0 Absolute neutrophil count (ANC) >= 1,500/mm^3 obtained =< 21 days prior to registration 360.0 Absolute neutrophil count (ANC) >= 1,800 cells/mm^3 285.0 Absolute neutrophil count (ANC) >= 1,800 cells/mm^3 37.0 Absolute neutrophil count (ANC) >= 1,500/mm^3 545.0 Within 60 days prior to registration on study: Absolute neutrophil count (ANC) >= 1,500/mm^3 2580.0 Absolute neutrophil count (ANC) >= 1200/mm^3 48.0 Absolute neutrophil count (ANC) >= 1,500/mm^3 1120.0 Absolute neutrophil count (ANC) >= 1,200 cells/mm^3, within 21 days prior to study entry 143.0 Within 14 days prior to registration: Absolute neutrophil count (ANC) >= 1,000 cells/mm^3 without growth factor support 130.0 Absolute neutrophil count (ANC) >= 1,500 cells/mm^3; obtained within 14 days prior to study entry 368.0 STEP I: Absolute neutrophil count >= 1000 cells/mm^3 (obtained within 28 days prior to randomization) 1080.0 Obtained =< 7 days prior to registration: Absolute neutrophil count (ANC) >= 1500/mm^3 102.0 Absolute neutrophil count (ANC) >= 1,800 cells/mm^3 252.0 Absolute neutrophil count (ANC) >= 1,000 cells/mm^3 234.0 Absolute neutrophil count (ANC) > 1,000/mm^3 2060.0 Absolute neutrophil count (ANC) >= 1,500 cells/mm^3 obtained within 30 days prior to registration 330.0 Absolute neutrophil count (ANC) > 750 cells/mm^3 within 90 days prior to randomization 150.0 Absolute neutrophil count (ANC) >= 1500 cells/mm^3 within 14 days prior to study registration 440.0 Absolute neutrophil count (ANC) >= 1,500/mm^3 34.0 Absolute neutrophil count (ANC) >= 1,500 cells/mm^3, within 21 days prior to registration 924.0 Absolute neutrophil count (ANC) >= 1,500/mm^3 20.0 Absolute neutrophil count (ANC) >= 500 cells/mm^3 84.0 Absolute neutrophil count (ANC) >= 1,500 cells/m^3 182.0 Absolute neutrophil count (ANC) >= 1,000/mm^3 30.0 Absolute neutrophil count (ANC) >= 1,500 cells/mm^3 606.0 Absolute neutrophil count (ANC) >= 1500/mm^3 NONE Absolute neutrophil count (ANC) >= 1,500/mm^3 420.0 Absolute neutrophil count (ANC) >= 500 cells/mm^3 360.0 Absolute neutrophil count (ANC) > 1500 mm^3, must be obtained within 8 weeks prior to screening for protocol therapy 562.0 ELIGIBILITY CRITERIA FOR RANDOMIZATION (STEP 1): Absolute neutrophil count (ANC) > 1500 mm^3 562.0 Absolute neutrophil count (ANC) >= 1500/mm^3 60.0 Within 6 weeks prior to randomization: Absolute neutrophil count (ANC) must be >= 1200/mm^3 990.0 Absolute neutrophil count (ANC) >= 1,500/mm^3 195.0 Re-registration: ANC >= 1,500/mm^3 195.0 Within 14 days of registration: Absolute neutrophil count (ANC) >= 1,500/mm^3 110.0 Absolute neutrophil count (ANC) >= 1,500/mm^3 69.0 Absolute neutrophil count (ANC) >= 1,500/mm^3 130.0 Absolute neutrophil count (ANC) >= 1,500/mm^3 45.0 Absolute neutrophil count (ANC) >= 1,500/mm^3 137.0 Absolute neutrophil count (ANC) must be >= 1200/mm^3 within 28 days before randomization 348.0 Absolute neutrophil count (ANC) >= 1,500/mm^3 124.0 Absolute neutrophil count (ANC): >= 1,500 /mm^3 56.0 Absolute neutrophil count (ANC) >= 1500 mm^3 700.0 Absolute neutrophil count (ANC) >= 750/mm^3 324.0 Absolute neutrophil count (ANC) >= 1,000 cells/mm^3 186.0 Absolute neutrophil count (ANC) >= 1,500 cells/mm^3 120.0