The subject has tumor invading or encasing any major blood vessels 55.0 The participant has tumor invading or encasing any major blood vessels 42.0 The subject has tumor in contact with, invading or encasing any major blood vessels 72.0 The subject has tumor in contact with, invading or encasing any major blood vessels 90.0 The subject has tumor invading any major blood vessels 135.0 Patient�s baseline imaging must not indicate the presence of tumor invading or encasing any major blood vessels 180.0 The subject has evidence of tumor invading the GI tract (esophagus, stomach, small or large bowel, rectum or anus), or any evidence of endotracheal or endobronchial tumor within 28 days before the first dose of cabozantinib 55.0 The subject has evidence of tumor invading the gastrointestinal (GI) tract (esophagus, stomach, small or large bowel, rectum or anus), or any evidence of endotracheal or endobronchial tumor within 28 days before the first dose of cabozantinib 72.0 The subject has evidence of tumor invading the gastrointestinal (GI) tract (esophagus, stomach, small or large bowel, rectum or anus), or any evidence of endotracheal or endobronchial tumor within 28 days before the first dose of cabozantinib 90.0 The subject has evidence of tumor invading the gastrointestinal (GI) tract (esophagus, stomach, small or large bowel, rectum or anus), or any evidence of endotracheal or endobronchial tumor within 28 days before the first dose of cabozantinib 135.0 Patients must not have cavitating pulmonary lesions; patients must not have tumor invading the gastrointestinal (GI) tract or evidence of endotracheal or endobronchial tumor within 28 days prior to registration 180.0 The subject has radiographic evidence of cavitating pulmonary lesion(s) 55.0 The participant has radiographic evidence of cavitating pulmonary lesion(s) 42.0 The subject has radiographic evidence of cavitating pulmonary lesion(s) 90.0