No active symptomatic ischemic heart disease, myocardial infarction or congestive heart failure within the past year; if multi gated acquisition (MUGA) is obtained, the left ventricular ejection fraction (LVEF) should exceed 40%
348.0
Ejection fraction >= 47% by radionuclide angiogram (multi gated acquisition scan [MUGA]); Note: the echocardiogram (or MUGA) may be done within 28 days prior to enrollment
253.0
Cardiac ejection fraction >= 45% or within institutional normal limits; a nuclear medicine gated blood pool examination is preferred; a two-dimensional (2-D) echocardiogram (ECHO) scan is acceptable if a calculated ejection fraction is obtained and follow-up measurement of the cardiac ejection fraction will also be performed by echocardiography; measurement of cardiac ejection fraction should be within two weeks prior to receiving treatment* NOTE: when a multi gated acquisition scan (MUGA) or echocardiogram cannot be obtained due to weekend or holiday, then patients may be enrolled provided there is no history of significant cardiovascular disease and a measurement of cardiac ejection fraction will be performed within 5 days of study enrollment
747.0
Patients must have a cardiac ejection fraction >= institutional lower limit of normal (ILLN) by multi gated acquisition (MUGA) scan or 2-dimensional (D) echocardiogram (ECHO) within 42 days prior to registration
155.0
Cardiac function:* Normal ejection fraction (>= 55%) documented by either echocardiogram or radionuclide multi gated acquisition scan (MUGA) evaluation; OR * Normal fractional shortening (>= 27%) documented by echocardiogram
62.0
Left ventricular ejection fraction >= institutional lower limit of normal (LLN) by echocardiogram (ECHO) or multi gated acquisition scan (MUGA)
30.0
Patients must not have a cardiac ejection fraction < 45% or the presence of New York Heart Association stage III or IV heart failure within 14 days prior to registration; either echocardiogram (ECHO) or multiple-gated acquisition scan (MUGA) may be used to determine ejection fraction
38.0
Left ventricular ejection fraction >= institutional lower limit of normal (LLN) by echocardiogram (ECHO) or multi gated acquisition scan (MUGA)
130.0
Patients must have a left ventricular ejection fraction >= lower limit of normal by echocardiogram (ECHO) or multigated acquisition scan (MUGA)
250.0
Patients must not have presence of class III or IV heart failure, according to New York Heart Association classifications, or a known left ventricular ejection fraction of less than 50%; Note: left ventricular ejection fraction (LVEF) evaluation by echocardiogram or multi-gated acquisition scan (MUGA) is not required prior to registration
230.0
Left ventricular ejection fraction >= institutional lower limit of normal (LLN) by echocardiogram (ECHO) or multi gated acquisition scan (MUGA)
35.0
Left ventricular ejection fraction (LVEF) =< 55% as determined by multi gated acquisition (MUGA) scan or echocardiogram (ECHO)
23.0
Patients must have a left ventricular ejection fraction (LVEF) >= institutional lower limit of normal (ILLN) by echocardiogram (ECHO) or multi gated acquisition scan (MUGA) within 28 days prior to registration
280.0
Left ventricular ejection fraction (LVEF) > 40% as assessed by echocardiogram or multi gated acquisition scan (MUGA)
52.0
Patients must have a left ventricular ejection fraction (LVEF) >= 50% by (either multigated acquisition [MUGA] or 2-dimensional [2-D] echocardiogram) within 28 days of registration
60.0
Left ventricular ejection fraction (LVEF) assessment must be performed within 90 days prior to randomization; (LVEF assessment performed by 2-dimensional [D] echocardiogram is preferred; however, multi gated acquisition [MUGA] scan may be substituted based on institutional preferences;) the LVEF must be >= 50% regardless of the cardiac imaging facility's lower limit of normal
990.0
New York Heart Association class I or less; ordinary physical activity does not cause undue fatigue, palpitations, dyspnea, or angina pain; patients 60 years or older must have a left ventricular ejection fraction (LVEF) at rest >= 40% measured by echocardiogram or multi-gated acquisition (MUGA)
302.0
Left ventricular ejection fraction of > 50% on baseline echocardiography or multi-gated acquisition (MUGA) scan
33.0
Left ventricular ejection fraction < 50% on echocardiogram or multi-gated acquisition (MUGA)
82.0
Patients with left ventricular ejection fraction < 50% on echocardiogram or multigated acquisition scan will be excluded
37.0
Left ventricular ejection fraction =< 50% as demonstrated by echocardiogram or multigated acquisition scan (MUGA)
46.0
Left ventricular ejection fraction (LVEF) >= 50% by 2-dimensional (2D) echocardiogram (ECHO) or multigated acquisition (MUGA) scan; timeline: within 4 weeks prior to enrollment
18.0
CLINICAL/LABORATORY CRITERIA: Patients must have a left ventricular ejection fraction (LVEF) >= institutional lower limit of normal (ILLN) by echocardiography (ECHO) or multi-gated acquisition scan (MUGA) within 42 days prior to registration
53.0
Patients must have an echocardiogram (ECHO) or multigated acquisition (MUGA) scan within 42 days prior to registration with a cardiac ejection fraction >= 45%
150.0
Shortening fraction >= 27% by echocardiogram
253.0
Patients must have a cardiac ejection fraction of >= 40%, or within institutional normal limits; a nuclear medicine gated blood pool examination is preferred; a 2-D ECHO scan is acceptable if a calculated ejection fraction is obtained and follow-up measurement of the cardiac ejection fraction will also be performed by echocardiography; measurement of cardiac ejection fraction should be within two weeks prior to allogeneic transplantation
747.0
Shortening fraction of >= 27% by echocardiogram, or ejection fraction of >= 50% by radionuclide angiogram
693.0
Cardiac ejection fraction >= 50% as determined by screening echocardiogram
45.0
Shortening fraction of >= 27% by echocardiogram (ECHO) OR
74.0
Ejection fraction >= 50% by ECHO or gated radionuclide study
74.0
Normal baseline cardiac ejection fraction >= 50%
70.0
Shortening fraction of >= 27% by echocardiogram, or
140.0
Ejection fraction of >= 50% by radionuclide angiogram
140.0
Patient must have a normal cardiac ejection fraction by pretreatment multigated acquisition scan (MUGA) or echocardiogram within 4 weeks prior to registration (resting ejection fraction >= 40% or >= 5% increase with exercise), shortening fraction by echocardiogram >= 24%, or to within the normal range of values for the institution
509.0
Shortening fraction of >= 27% by echocardiogram, or
598.0
Ejection fraction of >= 50% by radionuclide angiogram
598.0
Patients must have ejection fraction >= 45% based on echocardiogram performed within 28 days prior to registration
44.0
Patients with a history of congestive heart failure (CHF) or are at risk because of underlying cardiovascular disease or exposure to cardiotoxic drugs must have adequate cardiac function as clinically indicated:* Corrected QT interval (QTC) =< 480 msec* Shortening fraction of >= 27% by echocardiogram or ejection fraction of >= 50% by gated radionuclide study
484.0
Shortening fraction of >= 27% by echocardiogram, or ejection fraction of >= 50% by radionuclide angiogram
600.0
Shortening fraction of >= 27% by echocardiogram OR ejection fraction of >= 50% by radionuclide angiogram
340.0
Shortening fraction of >= 27% or
330.0
Ejection fraction of >= 50%
330.0
Normal ejection fraction (echocardiogram [ECHO]) >= 53% (if a range is given then the upper value of the range will be used) or cardiac MRI
50.0
Shortening fraction of >= 27% by echocardiogram, or ejection fraction of >= 50% by gated radionuclide study
67.0
Shortening fraction of >= 27% by echocardiogram, or
44.0
Ejection fraction of >= 50% by radionuclide angiogram or echocardiogram
44.0
Shortening fraction of >= 27% by echocardiogram, or
56.0
Ejection fraction of >= 50% by radionuclide angiogram or echocardiogram
56.0
RECURRENT/ PROGRESSIVE DIPG (STRATUM 1): Cardiac function: * Left ventricular ejection fraction >= 50 by gated radionuclide study OR shortening fraction of >= 27% by echocardiogram* Patient has no ventricular arrhythmias except for benign premature ventricular contractions* Patient has a corrected QT (QTc) interval =< 450 ms
50.0
NON-PROGRESSED DIPG (STRATUM 2): Left ventricular ejection fraction >= 50 by gated radionuclide study OR shortening fraction of >= 27% by echocardiogram
50.0
Ejection fraction of < 50% (by radionuclide angiogram or echocardiogram) or shortening fraction of < 25% (by echocardiogram)* Note: for instances where both are reported, and one is below the threshold, the site will have the option to re-measure it centrally at the core lab
250.0
Shortening fraction of >= 27% by echocardiogram, or ejection fraction of >= 50% by gated radionuclide study
65.0
Shortening fraction of >= 27% by echocardiogram
700.0
Ejection fraction of >= 50% by radionuclide angiogram or echocardiogram
700.0
Shortening fraction of >= 27% by echocardiogram, or ejection fraction of >= 50% by gated radionuclide study within 7 days prior to enrollment
49.0
Participants with known congestive heart failure (CHF); if known, patients with left ventricular ejection fraction (LVEF) =< 40% are excluded
90.0
Left ventricular ejection fraction (LVEF) >= 55%
180.0
Pediatric patients: normal left ventricular function with ejection fraction > 55% or shortening fraction >= 27%
73.0
Left ventricular ejection fraction (LVEF) >= institutional lower limit of normal
70.0
Left ventricular ejection fraction >= 45%
63.0
Systolic cardiac function will be assessed at screening if clinically indicated by history and physical; only patients with left ventricular ejection fraction (LVEF) >= 50% will be eligible for enrollment
28.0
Left ventricular ejection fraction (LVEF) >= 50% (measured within 28 days of study entry)
96.0
Patients must have left ventricular ejection fraction (LVEF) > 45% or within institutional normal limits
57.0
Left ventricular ejection fraction (LVEF) < 50%, regardless of whether there are symptoms of heart failure
50.0
Left ventricular ejection fraction (LVEF) >= 50%
84.0
If cardiac function assessment is clinically indicated or performed: participants will be ineligible if left ventricular ejection fraction (LVEF) is less than normal per institutional guidelines, or < 55%, if the threshold for normal is not otherwise specified by institutional guidelines
70.0
Patient must have a left ventricular ejection fraction >= institutional lower limit of normal (LLN) by echocardiogram (ECHO) or multigated acquisition (MUGA) within 28 days prior to registration
97.0
Left ventricular ejection fraction >= institutional lower limit of normal (LLN) by echocardiogram (ECHO)
40.0
Left ventricular ejection fraction >= institutional lower limit of normal (LLN) by echocardiogram (ECHO), within 2 weeks of the first dose of study treatment
18.0
Left ventricular ejection fraction >= institutional lower limit of normal (LLN) by echocardiogram (ECHO)
68.0
Left ventricular ejection fraction (LVEF) >= institutional lower limit of normal (LLN) by echocardiogram (ECHO) or multigated acquisition scan (MUGA)
68.0
Left ventricular >= institutional lower limit of normal (LLN) by echocardiogram (ECHO) ejection fraction
32.0
Left ventricular ejection fraction >= institutional lower limit of normal (LLN) by echocardiogram (ECHO)
18.0
Left ventricular ejection fraction (LVEF) >= institutional lower limit of normal (LLN) by echocardiogram (ECHO) or multigated acquisition scan (MUGA) within 30 days of day 1 of study
27.0