fish ihc hybridization situ fluorescence immunohistochemistry negative positive fluorescent breast 
receptor er estrogen progesterone pr positive negative breast epidermal growth 
tamoxifen aromatase raloxifene inhibitors therapy estrogen selective breast receptor cancer 
er pr positive breast cancer negative ihc staining receptor pgr 
receptor estrogen positive progesterone hormone breast cancer negative status tumor 
copy probe signals number average cep ihc ratio ish dual 
receptor negative ihc er pr progesterone estrogen immunohistochemistry hybridization fish