drug investigational weeks study preceding treatment prior start administration participation investigational agent weeks treatment study prior dose administration therapy initiation vaccine prevention infectious therapy non oncology diseases administration ipilimumab dose drug study administration dose days prior weeks following therapy treatment cpi treatment weeks cancer initiation past investigational prior received dose concurrently using antineoplastic approved patient anti neoplastic investigational therapy agent initiation treatment study prior days weeks therapy investigational drug cancer medi receipt dose anticancer prior days investigational therapy amp weeks agent investigational registration days treatment prior therapy protocol registered study product investigational days medicinal prior received treatment weeks administration study