cycle major surgery day days weeks prior recent diagnosis minor major surgery enrollment days weeks prior study month patients undergone major surgery drug dose study weeks days prior administration trauma use prior medications days chronic study intermittent day allowed patients undergone surgery major prior patients weeks debulking hours subjects days surgery major registration prior days weeks study eligible diagnostic patients procedure surgical major prior weeks days study day treatment surgery surgery day major weeks prior study days diagnostic recovered treatment major surgery days prior dose treatment study immunotherapy patients entering transurethral turp prostate resection prior prostatic surgery cryotherapy including procedure surgery major weeks dose prior study subject radiation lenvatinib treatment scheduled surgery undergo receive patients chemotherapy cancer study patient procedure start major surgery weeks study treatment prior recovery days complete isolated palliative intent local lesions surgery acceptable major procedure surgical