normalized inr international ratio uln coagulation anticoagulation warfarin anticoagulants blood anticoagulation therapeutic applies inr aptt normalized ratio thromboplastin activated international time aptt thromboplastin activated partial inr normalized ratio prothrombin international prothrombin inr normalized pt ratio international time uln normal seconds time inr ptt thromboplastin normalized partial ratio international prothrombin pt inr warfarin heparin normalized ratio international stable ptt time thromboplastin