advanced locally metastatic cancer breast unresectable incurable recurrent patients therapy 
pancreas adenocarcinoma histologically cytologically confirmed metastatic proven resectable patients ductal 
intolerable ineffective standard proven advanced exist locally therapy metastatic solid 
locally advanced metastatic disease unresectable resectable therapy patients prior treatment 
cytologically advanced histologically locally metastatic confirmed unresectable adenocarcinoma documented nsclc 
advanced histologically locally metastatic confirmed unresectable solid proven adenocarcinoma patients 
unresectable metastatic disease melanoma patients inoperable confirmed histologically tumor advanced