brain metastases known patients history active subjects presence patient treated 
leptomeningeal disease manifestation history presence evidence patients diffuse spread untreated 
meningitis carcinomatous subjects known history brain presence leptomeningeal patients metastases 
suspected metastasis leptomeningeal brain known active disease subject needing carcinomatosis 
leptomeningeal metastasis brain disease history known symptomatic presence active patients 
leptomeningeal metastases brain active cns evidence history known disease patients