severe disease uncontrolled systemic infection active concurrent morbidity current septicemia 
visceral disease crisis threatening metastases metastasis life rapid liver severe 
infection uncontrolled eligible patients subjects active stratum untreated study participation 
infection controlled antibiotics active eligible uncontrolled patients judged antimicrobial treatment 
threatening life infection uncontrolled active disease untreated patients antimicrobial severe 
spread threatening visceral term life short symptomatic complications risk advanced 
threatening life potentially autoimmune active disease second activated patients history