inability comply protocol requirements assessments investigator follow available study willing 
unable comply protocol requirements opinion investigator follow study patient consent 
monitoring safety comply opinion requirements able investigator study eligible patients 
noncompliance regimens medical history haart unreliable protocol comply unable therapy 
unwilling follow unable requirements protocol consent instruction informed render instructions 
abide cooperate fully unwilling designee unable protocol investigator study subject 
addictive preclude psychiatric disorders meeting conditions requirements opinion patient investigator 
unwilling comply unable protocol patients requirements study procedures assessed investigator 
exclude opinion investigator subject presence following study enrollment patient patients 
compliant initiative investigator means protocol patient opinion proximity team study