dihydropyrimidine deficiency dehydrogenase dpd known fluorouracil fluoropyrimidine hypersensitivity capecitabine severe 
gpd phosphate deficiency dehydrogenase glucose known history patients hereditary normal 
deficiency phosphate glucose dehydrogenase known history pd patients porphyria phosphatase 
oxaliplatin irinotecan fluoropyrimidine fluorouracil fu leucovorin bevacizumab capecitabine chemotherapy therapy