blasts marrow bone blood peripheral leukemic aml circulating patients leukemia aml mds patients prior cmml therapy blasts leukemia secondary relapsed leukemia acute biphenotypic blasts myeloid diagnosis lymphoblastic marrow remission lineage leukemia lymphoma acute hodgkin chronic myeloid lymphocytic lymphoblastic myeloma remission myeloid leukemia acute aml relapsed refractory blasts marrow patients remission lymphoblastic leukemia lymphoma acute cell patients precursor burkitt diagnosis relapsed