chimeric humanized fusion anaphylactic proteins antibodies reactions allergic hypersensitivity severe antibodies monoclonal hypersensitivity reactions severe history mabs allergy humanized reaction anaphylactic allergic reactions severe monoclonal antibody history reaction humanized murine hypersensitivity severe asthma monoclonal reactions antibodies nci anaphylaxis ctcae known allergens allergic unknown severe reactions components history drugs vaccines anaphylaxis dtpa gadolinium known gd acid reaction allergic dimeglumine anaphylactic acetic