medication oral able swallow unable dissolving consume crushing chewing patient unwilling comply unable eligible protocol patients swallow oral medication requirements pills swallow able ability patients unable impairs patient condition mouth inability oral swallow medications medication gastrointestinal absorption unwillingness absorb administration swallow tablet capsule able drugs ability study liquids drug unable swallow able study drug tablet comply requirements enzalutamide intolerance oral preclude oral illnesses absorption gastrointestinal olaparib medications able swallow cediranib fast maintain mln hours hour oral administration medication required able