untreated nervous central metastases cns active symptomatic brain known progressing 
cns metastases nervous central symptomatic untreated neurologically patients known primary 
cns metastases symptomatic untreated patients active known uncontrolled excluded brain 
excluded subjects metastases brain clinical trial cancers treated cns primary 
brain symptomatic metastases inclusive uncontrolled requiring corticosteroids limited concurrent radiation 
metastases brain known participants excluded patients corticosteroids treated imaging clinical 
brain metastases excluded trial clinical known patients participants untreated symptomatic