eligible patients disease study prior therapy treatment tumor provided criteria following criteria treatment satisfy cardiac patients diagnoses use combination patient ceritinib inclusion criteria prior dose capsules alk swallow gi therapy prior study criteria therapy disease treatment patients weeks history inclusion interventional agrees participate subject study treatment participant inclusion present randomization turnstile ii infusion equal til inclusion chemotherapy criteria cell patients meet criteria following inclusion patients laboratory subjects eligible study exclusion regorafenib prior use treatment criteria sunitinib inclusion tas patients exclusion cll sll iwcll treatment diagnosis therapy prior criteria patients received pre registration inclusion criteria optional tissue secondary days post cystectomy