excipients hypersensitivity known drugs intolerance study allergies allergy ribociclib history pembrolizumab excipients hypersensitivity severe known grade epacadostat substance active history palbociclib ribociclib cdk possible hypersensitivity fulvestrant endocrine excipients abemaciclib previous various analogues formulations excipients allergy medications agent known study allergic sirolimus temsirolimus everolimus hypersensitivity rapamycins known excipients analogs rapamycin intolerance classes excipients formulations hypersensitivity study drugs allergy suspected given drug allergies known drug intolerance subjects classes separate history vaccine adhesives azd structure similar inactive excipients chemical osimertinib drugs hypersensitivity class