cypa grapefruit metabolized window predominantly narrow medications therapeutic hybrids star ketoconazole itraconazole ritonavir clarithromycin telithromycin grapefruit voriconazole cypa inhibitors nelfinavir ritonavir verapamil erythromycin inhibitors amprenavir ketoconazole cypa indinavir clarithromycin itraconazole inhibitors cypa boosted boceprevir telaprevir ritonavir cobicistat ciprofloxacin diltiazem olaparib