fungal bacterial viral infection clinically significant exhibits active uncontrolled systemic 
bacterial fungal viral taking progression currently uncontrolled clinical medication symptoms 
infection improvement despite exhibiting signs bacterial fungal antibiotics viral appropriate 
bacterial fungal viral infection active uncontrolled systemic time enrollment controlled 
infections fungal bacterial viral active uncontrolled unresponsive infection patients therapy 
bacterial fungal viral requiring systemic active infection uncontrolled therapy infections