likely interfere illness psychiatric participation medical clinical study patients opinion 
subject study treatment protocol france investigator following french subjects condition 
preclude participation investigator condition opinion medical study trial safe clinical 
condition medical investigator opinion participation study interfere psychiatric protocol compliance 
interfere cooperate likely deemed ability participate condition mental investigator sign 
coexisting likely condition medical procedures interfere results study psychiatric hazard 
results interfere interpretation medical likely participation laboratory investigator history including 
patient study investigator participate treatment disease medical therapy protocol unlikely 
extenuating circumstance significantly additional interfere opinion illness compliance condition medical 
psychological medical condition compliance investigator compromise participation social opinion study