lymphoma nervous central cns known leptomeningeal primary active history patients involvement nervous central known lymphoma active leukemia myeloma patients history lymphoma cell mantle leukemia nk large patients primary cutaneous ptcl leukemia cns nervous central active known patients clinically evidence clinical cns disease patients lymphoma nervous central active leukemia primary eligible nervous central cns disease active malignancy patients history known primary intravascular disseminated coagulation dic leukostasis evidence cns bleeding leukemia uncontrolled involvement cns nervous central active known malignancy leukemia leptomeningeal lymphoma