forms medically sexually acceptable willing contraception able women use childbearing condom intercourse drug males father sexually vasectomized stopping taking child men wocbp sexually contraception instructed nivolumab azoospermic adhere active women sexually males contraception effective childbearing potential use active accepted women methods accepted medically sexually contraception fertile male female partners agree final contraception method partner sexually effective product childbearing nonsterilized potential bear beget children agreement sexually able study contraception dose use