reaction antibody monoclonal hypersensitivity severe history mab components infusion allergy pembrolizumab nivolumab hypersensitivity prior dose treatment received therapy known mk mannitol hypersensitivity boron bortezomib azacitidine known suspected allergy velcade history talazoparib components hypersensitivity known capsule suspected bmn treatment previous prior reaction allergic history prior hypersensitivity involved known severe protocol drug component hypersensitivity known formulation allergy bevacizumab study reaction history drug components allergy history drug study known hypersensitivity nivolumab treatment reaction fentanyl allergy history propofol opioids patches transdermal tolerant lidocaine midazolam formulation components allergy hypersensitivity identified previously study subject treatment known formulations allergy components hypersensitivity identified previously component study known cobimetinib