newly diagnosed cancer patients breast histologically stage disease untreated confirmed stage iv cancer breast disease metastatic iii patients diagnosed diagnosis breast diagnosis cancer stage years confirmed current hr primary patients stage melanoma iv unresectable iii histologically confirmed metastatic diagnosis iiic pheochromocytoma patients concurrent diagnosis metastatic regorafenib biochemically phases untreated hyper stage breast cancer iii ii diagnosed diagnosis early newly histologically stage iii iv ii arbor ann disease cancer iva figo stage disease clinical patients ib iiia bclc ii ia cancer colorectal cancer metastatic chemotherapy patients crc diagnosed prior stage breast