effects recovered prior toxic therapy acute fully grade chemotherapy radiotherapy days prior registration study therapy treatment dose radiotherapy enrollment growth weeks earlier administered adverse events recovered agents prior entering study treatment prior previous study patients weeks therapy allowed dose anti laboratory values parameters clinical following abnormalities study places clia range major surgery weeks prior study days recovered drug dose effects stable dose decreasing corticosteroids prior days patients weeks corticosteroid enrollment weeks prior radiotherapy therapy chemotherapy study treatment dose nitrosoureas mitomycin mg equivalent prednisone day dose corticosteroids daily corticosteroid systemic steroids start treatment prior study weeks days trial investigational therapy radiotherapy