heart angina myocardial infarction unstable congestive failure cardiac months uncontrolled 
rituximab containing prior therapy treatment regimen refractory months received chemotherapy 
platinum based chemotherapy regimen disease progression therapy line prior resistant 
hormone releasing lhrh luteinizing therapy agonist thyroid androgen orchiectomy gnrh 
adjuvant chemotherapy neoadjuvant therapy prior setting months metastatic neo treatment 
myocardial infarction months angina unstable history prior coronary study stroke 
metastatic disease evidence patients distant prior chemotherapy therapy recurrent cancer