bone marrow function adequate involvement cells blood biopsy patients prior 
organ function adequate marrow defined hematologic end laboratory bone days 
function adequate liver renal marrow bone kidney defined hematological inadequate 
pugh child class score hepatic impairment cirrhosis liver severe classification 
hepatic function adequate renal marrow bone defined hematological coagulation cardiac 
hematologic function adequate renal hepatic inadequate coagulation liver defined toxicity