illness compliance social requirements psychiatric intercurrent situations uncontrolled limit study 
compliance psychological safety condition protocol study conditions psychiatric medical procedures 
staff medical regimens conduct history noncompliance compliance study planning non 
trial confound best abnormality results interfere participate laboratory duration current 
illness medical psychiatric interfere condition prevent opinion abnormality potentially likely 
illness pectoris social situations intercurrent arrhythmia uncontrolled compliance congestive limited 
inappropriate make judgment study investigator severe interfere patient entry increase 
interfere results study interpretation condition medical investigator participation opinion evaluation 
cooperation substance abuse disorders interfere psychiatric requirements trial known study 
opinion condition investigator medical study subject compromise patient participation safety