metastasis brain leptomeningeal known distant patients symptomatic suspected cns evidence 
brain metastases known patients treated stable trial excluded clinical evidence 
disease progression progressive patients evidence leptomeningeal therapy refractory treatment prior 
nervous central cns metastases active known untreated disease meningitis lymphoma 
cord spinal compression brain metastases leptomeningeal untreated symptomatic stable disease 
cns metastases nervous central patients disease stable symptomatic treated brain