therapies prior received number anti patients therapy cancer anticancer treatment pd programmed anti death ligand cell lymphocyte ctla antibody cytotoxic concurrent therapy investigational agents chemotherapy cancer treatment use immunotherapy anti chemotherapy prior received cytotoxic patients regimen treatment cancer regimens systemic therapy prior anti chemotherapy systemic cancer hormonal treatment patients radiation radiation therapy prior weeks chemotherapy treatment patients study received palliative pelvic radiation prior radiotherapy irradiation previous abdominal therapy history patients pd inhibitor ctla prior anti treatment therapy including durvalumab previous prostate cancer adenocarcinoma prior biopsy therapy diagnosis treatment prostatectomy chemotherapy neck head radiation squamous carcinoma cancer cell prior therapy cavity anti pd ctla antibody prior therapy received checkpoint targeting agent