cardiac significant disease arrhythmia function history impaired arrhythmias requiring uncontrolled 
retinal rvo occlusion vein history evidence current retinopathy serous risk 
significant clinically disease cardiac history uncontrolled pulmonary investigator active ecg 
cardiovascular significant disease clinically uncontrolled history including evidence pulmonary condition 
pleural ascites effusion effusions pericardial requiring paracentesis drainage clinically thoracentesis