Patients post-prostatectomy with baseline Gleason >=  (per prostatectomy pathology)
Pathologically (histologically) proven diagnosis of adenocarcinoma of the prostate as confirmed at time of prostatectomy; prostatectomy must have been performed =<  days ( year) prior to step  registration any type of radical prostatectomy is permitted, including retropubic, perineal, laparoscopic or robotically assisted; (please note: Prior ablative treatment for benign prostatic hypertrophy or focal high-intensity focused ultrasound therapy [HIFU] prior to prostatectomy is allowed)
Gleason sum of , , , or  at the time of prostatectomy
Previous prostate cancer surgery to include: prostatectomy, hyperthermia and cryosurgery.
Previous prostate cancer surgery to include: prostatectomy, hyperthermia and cryosurgery.
Patient and urologist must agree that patient is suitable for prostatectomy
Indications for post-prostatectomy radiation exist:\r\n* Disease progression (detectable PSA on two measurements obtained at least one month apart) or\r\n* Indications for adjuvant radiation exist (if undetectable PSA): pathologic T, T, N+ disease or positive margins (within  year of prostatectomy)
If have untreated primary prostate cancer: must undergo debulking prostatectomy
Patient is suitable for prostatectomy.
Prior prostatectomy
Diagnosis of prostate cancer undergoing prostatectomy
Willing to use appropriate contraception from time of NanoPac injection until prostatectomy
Prior prostatectomy
Prior local therapy with prostatectomy required, with available tissue from prostatectomy specimen to send for genomic and transcriptomic testing; specifically, either formalin-fixed paraffin-embedded (FFPE) blocks or - unstained slides from the primary prostatectomy specimen will need to be available for central pathologic review and processing
No prior prostatectomy or prostatic radiation
Prior prostatectomy
Willingness to use barrier contraception from the time of first dose of MGA until the time of prostatectomy
Willing to undergo prostatectomy as primary treatment for localized prostate cancer
Prior total prostatectomy or cryotherapy of the prostate
Patients who received hormone therapy before prostatectomy
Previous prostatectomy, cryosurgery, or high intensity focused ultrasound (HIFU) for prostate cancer
Previous prostate cancer surgery to include: prostatectomy, hyperthermia and cryosurgery
No prior prostatectomy or cryotherapy of the prostate
Neoadjuvant hormonal therapy prior to radical prostatectomy is allowed, and post-prostatectomy hormonal therapy is allowed only if the onset of androgen ablation is =<  days prior to the date of registration
Presence of multiple small bowel loops trapped within the immediate tumor bed (post hysterectomy or prostatectomy)
Androgen deprivation therapy started prior to prostatectomy for >  months ( days) duration; \r\n* Note: The use of finasteride or dutasteride ( tamsulosin) for longer periods prior to prostatectomy is acceptable
Neoadjuvant chemotherapy before or after prostatectomy
Histologically confirmed recurrent adenocarcinoma of the prostate =<  year prior to registration and >=  months following localized treatment of: \r\n* EBRT or\r\n* Permanent prostate brachytherapy or\r\n* High dose rate brachytherapy or\r\n* Any combination of the above radiotherapy treatments or\r\n* Prostatectomy; patients who have a localized recurrence following prostatectomy with a discernible mass identifiable on trans-rectal ultrasound that can be readily accessed as judged by the treating urologist or radiation oncologist
History of salvage prostatectomy
Patients must have undergone local treatment via prostatectomy or radiation therapy
Prior prostatectomy
History of diagnosis of prostate cancer after undergoing prostatectomy
Scheduled to undergo a prostatectomy at Johns Hopkins
Subjects must be able to safely be on lithium carbonate treatment for a period of at least four weeks prior to the scheduled prostatectomy
The study population will consist of patients who have undergone primary therapy (prostatectomy or primary radiation) for biopsy-proven adenocarcinoma of the prostate and now have biochemical-only recurrence
Completion of appropriate prior treatment with local therapy (i.e., prostatectomy, radiation therapy or equivalent), per National Comprehensive Cancer Network (NCCN) guidelines
Patients having robotic prostatectomy.
Prostatectomy with or without radiation for the pilot study patients only
Planned SRT for recurrence after primary prostatectomy.
Neoadjuvant chemotherapy or radiation therapy prior to prostatectomy including focal ablation techniques (high-intensity focused ultrasound ablation [HiFu])
SUB-STUDY I: No prostatectomy scheduled more than  hours post imaging
Neoadjuvant chemotherapy or radiation therapy prior to prostatectomy\r\n* Including focal ablation techniques (high-intensity focused ultrasound therapy [HiFu])
Patients will have been originally diagnosed with prostate carcinoma and have undergone what was considered definitive non-prostatectomy therapy for localized disease
Neoadjuvant chemotherapy or radiation therapy prior to prostatectomy
No prior local therapy (prostatectomy, radiation, cryotherapy) or hormonal therapy for prostate cancer
Prostatectomy at M. D. Anderson within  months from the time of MRSI
Patients will have been originally diagnosed with localized (stage Tc, T, or T) prostate carcinoma and have undergone what was considered definitive non-prostatectomy therapy for localized disease
Greater than T disease in past and/or treated with prostatectomy
All men undergoing robotic prostatectomy or cystoprostatectomy at City of Hope will be eligible for the study
Patients who have had prior prostatectomy or prior androgen therapy
Prior history of prostatectomy