Creatinine level greater than . times the upper limit of normal Creatinine < . times institutional upper limit of normal, within days prior to study entry Serum creatinine < . times upper limit of normal OR AST less than times the upper limit of normal Serum creatinine less than times upper limit of normal Serum creatinine =< . times upper limit of institutional normal for age, or and documented within days prior to registration and within days prior to the start of treatment Serum creatinine value of < . times the upper limit of normal (ULN) Creatinine < . times upper limit of normal Serum creatinine < . times upper limit of normal; OR Serum creatinine < . times institutional upper limit of normal Serum creatinine > times the upper limit of normal Liver aminotransferase levels greater than times the laboratory's upper limit of normal (greater than times the laboratory's upper limit of normal if the liver is known to be involved with tumor) Serum creatinine ? . mg/dl, serum glutamate oxaloacetate transaminase (SGOT) and bilirubin ? . times upper limit of normal Creatinine ? times upper limit of normal Serum creatinine of =< . times upper limit of normal Serum creatinine value of =< . times the upper limit of normal (ULN) EXCLUSION CRITERIA FOR ENROLLMENT: Creatinine >= . times the upper limit of normal (ULN) Serum creatinine < . times the upper limit of normal Serum creatinine > . times the upper limit of normal Serum creatinine =< . times the upper limit of normal (ULN) (normal: =< . mL/min/. m^) Serum creatinine concentration, . times greater than the upper limit of laboratory normal ranges (ULN), except if related to ALL/LBL, Serum creatinine =< . times the upper limit of normal AST less than times the upper limit of normal Serum creatinine less than times the upper limit of normal Creatinine =< times upper limit of normal Serum creatinine < . times upper limit of normal Serum creatinine < . times upper limit of normal Serum creatinine =< . times upper limit of institutional for age or Liver enzymes less than three times the upper limit of normal Serum creatinine . times or less than upper limit of normal Screening Laboratory Values Hemoglobin ? g/dL White blood cell count ? , cells/mm Absolute neutrophil count ? , cells/mm Total bilirubin ? times upper limit of normal Serum AST and ALT ? . times upper limit of normal Serum creatinine concentration ? mg/mL Pregnancy test: negative for females of childbearing potential Evidence of abnormal liver function (serum ALT level(s) > times upper limit of normal at screening or creatinine levels > times upper limit of normal at screening); PT and PTT < . times the institutional upper limit of normal. Renal disease: serum creatinine > times upper limit of normal Serum creatinine < . times the upper limit of normal AST > times upper normal limit Serum creatinine =< . times the institutional upper limit of normal Serum creatinine less than times upper limit of normal Creatinine =< times upper limit of normal Serum creatinine less than times upper limit of normal Creatinine =< . times the upper limit of normal (ULN) Within days prior to randomization: Serum creatinine =< . times upper limit of normal (ULN) Serum creatinine =< . times the upper limit of normal Serum creatinine . times or less than upper limit of normal Creatinine within . times of the institution's upper limit of normal (ULN) Serum creatinine < . times upper limit of normal; OR Serum creatinine > times the upper limit of normal Creatinine < . times upper normal limit Creatinine =< . times the upper limit of normal Liver enzymes =< times the upper limit of normal Serum creatinine =< . times the upper limit of normal (ULN) Creatinine =< . times the institutional upper limit of normal Creatinine > . times upper normal limit Creatinine > . times the institutional upper limit of normal Serum creatinine =< times upper limit of normal Creatinine =< . times upper limit of normal (ULN) Creatinine < . times upper limit of normal (ULN) Creatinine =< . times upper limit of normal (ULN) Serum creatinine < . times upper limit of laboratory normal Patients must have adequate bone marrow function (ANC = or > ,/mm^ and platelet count of = or > ,/mm^), adequate liver function (SGPT = or < times upper limit of normal and alkaline phosphatase = or < times upper limit of normal, bilirubin = or <. mg/dl), adequate renal function (BUN and creatinine = or <. times upper limit of normal) and normal serum amylase and lipase prior to starting therapy. Elevated cholesterol and triglycerides are not a contraindication to study enrollment, but should be managed as clinically appropriate by the treating physician. Creatinine < times upper limit of normal Serum creatinine of at least . times the upper limit of normal Serum creatinine =< times the upper limit of normal Creatinine < . times the upper limit of normal Serum creatinine =< . times the institutional upper limit of normal (ULN) Hepatic insufficiency (> . times the upper normal limit of transaminase levels) Inadequate renal function as indicated by serum creatinine >= . times the upper limit of normal INR and aPTT < . times upper limit of normal for age. Creatinine ? times the upper limit of normal (ULN) PT and aPTT each < . times the upper limit of normal. Grade renal dysfunction: creatinine > - times the upper limit of normal Obtained =< days prior to registration: Serum creatinine =< . times the institutional upper limit of normal (ULN); NOTE: can be waived with permission of study chair (documentation such as an email must be provided) Creatinine < . times the upper limit of normal, or: Baseline creatinine (Cr) no greater than . times the upper limit of normal Serum creatinine =< times the upper limit of normal Serum creatinine must be < . times the upper limit of the institutional normal range; test results must be no more than months old Serum creatinine < . times the upper limit of normal Creatinine =< . times the upper limit of normal SUB-STUDY III: Serum creatinine > times the upper limit of normal Serum creatinine > times the upper limit of normal Serum creatinine > times the upper limit of normal Serum creatinine > . times upper limit of normal Serum creatinine > times the upper limit of normal Creatinine >= . times upper limit of normal Creatinine >= . times upper limit of normal Serum creatinine > times the upper limit of normal Creatinine =< . times the institution upper limit of normal (ULN) Creatinine > . times the institution upper limit of normal (ULN) PT and PTT ? . times the upper limit of normal