The subject has received cytotoxic chemotherapy (including investigational cytotoxic chemotherapy) or biologic agents (eg, cytokines or antibodies) within weeks, or nitrosoureas/mitomycin C within weeks before the first dose of study treatment Patients who have had chemotherapy (including investigational cytotoxic chemotherapy), biologic agents (e.g., cytokines or antibodies) within weeks ( weeks for nitrosoureas or mitomycin C) before the first dose of study treatment The subject has received cytotoxic chemotherapy (including investigational cytotoxic chemotherapy) or biologic agents (e.g., cytokines or antibodies) within weeks, or intravesical Bacillus Calmette-Guerin (BCG) within weeks of the first dose of study treatment Received cytotoxic chemotherapy, radiation therapy, or targeted therapy (including investigational cytotoxic chemotherapy) or biologic agents (e.g., cytokines or antibodies) within days of study enrollment. The subject has received cytotoxic chemotherapy or biologic agents (e.g., cytokines or antibodies) within days, or nitrosoureas/mitomycin C within weeks before the first dose of study treatment Patients who have had chemotherapy (including investigational cytotoxic chemotherapy), biologic agents (e.g. targeted therapy or antibodies) or radiotherapy within weeks prior to the first dose of study treatment The patient has received cytotoxic chemotherapy (including investigational cytotoxic chemotherapy) within weeks or biologic agents (e.g., cytokines or antibodies) within weeks prior to study enrollment The subject has received cytotoxic chemotherapy (including investigational cytotoxic chemotherapy) or biologic agents (e.g., cytokines or antibodies) within weeks, or nitrosoureas/mitomycin C within weeks before the first dose of study treatment Received cytotoxic chemotherapy (including investigational cytotoxic chemotherapy) or biologic agents (eg, cytokines or antibodies) within weeks, or nitrosoureas/mitomycin C within weeks before the first dose of study treatment The subject has received cytotoxic chemotherapy (including investigational cytotoxic chemotherapy) or biologic agents (e.g., cytokines or antibodies; including investigational biologic agents) within weeks, or nitrosoureas/ mitomycin C within weeks before the first dose of study treatment The subject has received cytotoxic chemotherapy (including investigational cytotoxic chemotherapy), biologic agents (e.g. cytokines or antibodies) within weeks, or any other anti-cancer systemic therapy (including multi-kinase inhibitors) The subject has received cytotoxic chemotherapy (including investigational cytotoxic chemotherapy) or biologic agents (eg, cytokines or antibodies) within weeks, or nitrosoureas/mitomycin C within weeks before the first dose of study treatment Patients who have had chemotherapy (including investigational cytotoxic chemotherapy), biologic agents (e.g., cytokines or antibodies) or radiotherapy within weeks ( weeks for nitrosoureas or mitomycin C) before the first dose of study treatment or those who have not recovered from adverse events due to agents administered more than weeks earlier No cytotoxic chemotherapy including investigational cytotoxic chemotherapy or biologic agents (e.g., cytokines or antibodies) within the last weeks, or nitrosoureas/mitomycin C within weeks before the first dose of study treatment; at least weeks must have elapsed if the last regimen included an anti-cytotoxic T-lymphocyte antigen (CTLA) antibody; patients must have experienced disease progression on their prior therapy in the opinion of the treating investigator Cytotoxic chemotherapy (including investigational cytotoxic chemotherapy) or biologic agents (e.g., cytokines or antibodies) within weeks, or nitrosoureas/mitomycin C within weeks before the first dose of study treatment Prior treatment with other anti-cancer therapies including cytokines, monoclonal antibodies, immunotherapies, and cytotoxic chemotherapy is allowed The subject has received cytotoxic chemotherapy (including investigational cytotoxic chemotherapy) or biologic agents (eg, cytokines or antibodies) within weeks, or nitrosoureas or mitomycin within weeks before the first dose of study treatment The patient has received cytotoxic chemotherapy (including investigational cytotoxic chemotherapy) or biologic agents (e.g., cytokines or antibodies) within weeks, or nitrosoureas or mitomycin within weeks before the first dose of study treatment The participant has received cytotoxic chemotherapy (including investigational cytotoxic chemotherapy) or biologic agents (e.g., cytokines or antibodies) within weeks, or nitrosoureas/ mitomycin C within weeks before the first dose of study treatment The subject has received cytotoxic chemotherapy (including investigational cytotoxic chemotherapy) or biologic agents (eg, cytokines or antibodies) within weeks, or nitrosoureas/ mitomycin C within weeks before the first dose of study treatment The subject has received cytotoxic chemotherapy (including investigational cytotoxic chemotherapy) or biologic agents (e.g., cytokines or antibodies) within weeks, or nitrosoureas/mitomycin C within weeks before the first dose of study treatment The subject has received cytotoxic chemotherapy (including investigational cytotoxic chemotherapy) or biologic agents (e.g., cytokines or antibodies) within weeks, or nitrosoureas/mitomycin C within weeks before the first dose of study treatment