Patients being actively treated for a secondary malignancy Active secondary malignancy Secondary malignancy. Patients with a secondary condition (sickle cell anemia) that cause priapism No active secondary malignancy Cold agglutinin syndrome secondary to infection, rheumatologic disease, or active hematologic malignancy History of diseases with influence on bone metabolism, such as Pagets disease, osteogenesis imperfecta, active primary or secondary hyperparathyroidism, and primary or secondary hyperthyroidism within months prior to study entry Any form of active primary or secondary immunodeficiency Patients who have had secondary debulking surgery SECONDARY REGISTRATION-EXCLUSION: Patients with active secondary malignancy unless approved by the study chair Known secondary HPS that is otherwise treatable (e.g. non-Hodgkins lymphoma) Patients with active secondary malignancy will not be eligible unless approved by the principal investigator Concomitant administration of investigational drugs is not allowed; if investigational drugs were given, their use should be completed as guided by that protocol prior to initiation of cytoreduction on this protocol; if the patient is being treated for secondary (treatment related) myelodysplasia after treatment for a non-hematologic malignancy (e.g. Sarcoma), the primary disease should be in remission for at least months after completing primary therapy; patients with secondary myelodysplasia after treatment of a lymphoma, may proceed with treatment with the lymphoma responding or stable but not progressing Patients with primary or secondary immunodeficiencies Cold agglutinin syndrome secondary to infection, rheumatologic disease, or active hematologic malignancy Any active secondary malignancy Patients treated with other secondary hormonal therapies Patients with T disease accompanied by the presence of hydronephrosis secondary to the primary tumor Patients with a known history of primary and secondary adrenal insufficiency are not eligible Active secondary malignancy Any form of active primary or secondary immunodeficiency Patients with any form of active primary or secondary immunodeficiency. Patients must not have an active secondary malignancy Patients who are not candidates for interval surgical debulking secondary to significant medical comorbidities Any form of active primary or secondary immunodeficiency Subjects being actively treated for a secondary malignancy. Active treatment for a secondary malignancy Secondary malignancy, with the exception of: Has active secondary malignancy that requires treatment. Undergoing active treatment for a secondary malignancy. Subjects being actively treated for a secondary malignancy. Presence of an active secondary malignancy. Patients with active secondary malignancy will not be eligible Secondary immune thrombocytopenia No other known active secondary primary malignancy SECONDARY ELIGIBILITY Primary or secondary CNS lymphoma Cohorts & only: Patients with secondary brain tumors must be greater than or equal to weeks from radiotherapy. Patients with progressive secondary brain tumors will not be enrolled under this protocol following the completion of Cohort . Any form of active primary or secondary immunodeficiency Secondary cancer diagnosis within the last years Secondary malignancy Patient with a secondary malignancy who would be otherwise eligible for study, but for whom remission from the primary disease cannot be conclusively confirmed or for whom the chance of relapse of the primary disease is significant Primary or secondary tumor in the oral cavity Jaundice secondary to a cause other than biliary duct obstruction Patients diagnosed with secondary hepatic malignancy History of or currently active primary or secondary immunodeficiency. History of secondary hyperparathyroidism SECONDARY ELIGIBILITY (STEP ) - SECONDARY GENETIC COUNSELING SUBSTUDY: Failed prior therapy with a secondary hormone (e.g. enzalutamide, abiraterone) with documented progressive disease (post-secondary hormone CRPC) For pre-secondary hormone patients, no prior or concurrent treatment with a secondary hormone (e.g. enzalutamide, abiraterone) For post-secondary hormone patients, no concurrent treatment with a secondary hormone (e.g. enzalutamide, abiraterone), no metastasis to the liver or brain