Any Grade >/= hemorrhage or bleeding event within days of Day of Cycle Any grade >/= hemorrhage or bleeding event within weeks prior to initiation of study treatment Any hemorrhage or bleeding event ? grade within weeks. Any Grade >= hemorrhage or bleeding event within days of Day of Cycle Grade ? hemorrhage or bleeding event within days prior to initiation of study treatment FOR ALL PHASES (Ib AND II): Patients with evidence or history of bleeding diathesis; any hemorrhage or bleeding event >= CTCAE grade within weeks of start of study medication Patients with evidence or history of bleeding diathesis; any hemorrhage or bleeding event >= CTCAE grade within weeks before the start of study treatment Patients with evidence or history of bleeding diathesis; any hemorrhage or bleeding event >= CTCAE grade within weeks of start of study enrollment Contraindication to antiangiogenic agents, including:\r\n* Serious non-healing wound, non-healing ulcer, or bone fracture\r\n* Major surgical procedure or significant traumatic injury within weeks prior to initiating study treatment\r\n* Pulmonary hemorrhage/bleeding event >= grade (Common Terminology Criteria for Adverse Events [CTCAE] v.) within weeks prior to initiating study treatment\r\n* Any other hemorrhage/bleeding event >= grade (CTCAE v.) within weeks prior to initiating study treatment Contraindication to antiangiogenic agents, including:\r\n* Serious non-healing wound, non-healing ulcer, or bone fracture\r\n* Major surgical procedure or significant traumatic injury within weeks prior to initiating study treatment\r\n* Pulmonary hemorrhage/bleeding event >= grade within weeks prior to initiating study treatment\r\n* Any other hemorrhage/bleeding event >= grade within weeks prior to initiating study treatment Contraindication to antiangiogenic agents, including:\r\n* Bronchopulmonary hemorrhage/bleeding event >= grade (National Cancer Institute [NCI] Common Terminology Criteria for Adverse Events [CTCAE] version .) within weeks or less prior to first dose of study drug\r\n* Any other hemorrhage/bleeding event >= grade (CTCAE version [v].) within weeks or less prior to first dose of study treatment\r\n* Radiological evidence of any intracranial hemorrhage within the weeks or less prior to first dose of study treatment \r\n* History of significant intratumoral, intracerebral, or subarachnoid hemorrhage\r\n* Serious non-healing wound, ulcer, or bone fracture\r\n* Documented bowel perforation within months of the start of study treatment Any other hemorrhage/bleeding event >= CTCAE grade within weeks of first dose of study drug Grade or higher bleeding event =< months prior to randomization Any hemorrhage / bleeding event ? CTCAE v.. Grade within weeks before randomization Patients who have a history or current evidence of bleeding disorder, i.e., any hemorrhage/bleeding event of CTCAE grade >= , =< days prior to registration Contraindication to antiangiogenic agents, including:\r\n* Serious non-healing wound, non-healing ulcer, or bone fracture\r\n* Major surgical procedure or significant traumatic injury within weeks prior to initiating study treatment; other surgical procedures within weeks prior to initiating study treatment\r\n* Pulmonary hemorrhage/bleeding event >= grade within weeks prior to initiating study treatment\r\n* Any other hemorrhage/bleeding event >= grade within weeks prior to initiating study treatment Patients with evidence or history of bleeding diathesis; any hemorrhage or bleeding event >= CTCAE grade within weeks prior to registration Any hemorrhage or bleeding event >= grade within weeks prior to prior to registration Pulmonary hemorrhage/bleeding event >= CTCAE grade within weeks of first-dose of study drug Any other hemorrhage/bleeding event >= CTCAE grade within weeks of first dose of study drug Patients with any pulmonary hemorrhage/bleeding event grade or higher within weeks before randomization Have experienced a Grade ? bleeding event within months (? months) prior to randomization. Pulmonary hemorrhage/bleeding event >= CTCAE grade within weeks of study registration Any other hemorrhage/bleeding event >= CTCAE grade within weeks of study registration Pulmonary hemorrhage/bleeding event > or equal to CTCAE v grade within weeks of first dose of study drug Any other hemorrhage/bleeding event > or equal to CTCAE v grade within weeks of first dose of study drug Evidence or history of bleeding diathesis or any hemorrhage or bleeding event > CTCAE grade =< weeks prior to randomization Evidence or history of tendency or predisposition to active bleeding. Any hemorrhage or bleeding event of Grade or higher within weeks of start of study medication; Pulmonary hemorrhage/bleeding event >= CTCAE grade within weeks of first dose of study drug Any other hemorrhage/bleeding event >= CTCAE grade within weeks of first dose of study drug Evidence or history of bleeding diathesis; any hemorrhage or bleeding event >= grade within weeks of start of FOLFIRI CTCAE version . > grade pulmonary hemorrhage or > grade of other forms of bleeding within days prior to enrollment. Contraindication to antiangiogenic agents, including: \r\n* Pulmonary hemorrhage/bleeding event >= grade within weeks of first dose of study drug\r\n* Any other hemorrhage/bleeding event >= grade within weeks of first dose of study treatment\r\n* Serious non-healing wound, ulcer, or bone fracture Subjects who have a history of, or current evidence of bleeding disorder, i.e. any hemorrhage / bleeding event of CTCAE Grade >= < weeks before the first dose of study drug. Any hemorrhage or bleeding event Pulmonary hemorrhage/bleeding event >= CTCAE grade within weeks of first dose of study drug Any other hemorrhage/bleeding event >= CTCAE grade within weeks of first dose of study drug Pulmonary hemorrhage/bleeding event > CTCAE grade within weeks of study entry Any other hemorrhage/bleeding event > CTCAE grade within weeks of study entry Any other hemorrhage or bleeding of Grade ? within days prior to first dose of study treatment Evidence or history of bleeding disorder, i.e. any hemorrhage / bleeding event of > Grade within weeks prior to the first dose of study drug Any hemorrhage or bleeding event >= grade within weeks prior to registration Pulmonary hemorrhage/bleeding event >= CTCAE v . grade within weeks of first dose of study drug Any other hemorrhage/bleeding event >= CTCAE v . grade within weeks of first dose of study drug Has experienced a Grade ? bleeding event within months prior to randomization Any other hemorrhage/bleeding event >= CTCAE grade within weeks of first dose of study drug Any other hemorrhage/bleeding event >= CTCAE Grade within weeks of first dose of study drug