History of stroke or transient ischemic attack Subjects with prior history of myocardial infarction, transient ischemic attack, or stroke in the last months History of arterial thrombosis (eg, stroke or transient ischemic attack) within months of first dose of AMG History of arterial thrombosis (eg, stroke or transient ischemic attack) in the past months. History of stroke or transient ischemic attack within the previous months History of stroke, reversible ischemic neurological defect, or transient ischemic attack within months prior to Day History of stroke, reversible ischemic neurological defect, or transient ischemic attack within months prior to initiation of study treatment History of stroke or transient ischemic attack within months prior to registration History of arterial thrombosis (eg, stroke or transient ischemic attack) in the past months Infection requiring intravenous antibiotics within week of study enrollment (day ) History of stroke or transient ischemic attack within months prior to day History of arterial thrombosis (eg, stroke or transient ischemic attack) within months of enrollment. History of stroke or transient ischemic attack within months of the randomization History of stroke, reversible ischemic neurological defect, or transient ischemic attack within months prior to Day Symptomatic carotid artery disease, as manifested by a recent transient ischemic attack (within days), ischemic stroke, or amaurosis fugax (monocular visual ischemic symptoms or blindness). Cerebrovascular disease manifested as prior stroke at any time or transient ischemic attack (TIA) in the months prior to initiation of therapy History of stroke or transient ischemic attack within months prior to registration PHASE I AND II SCLC AND UROTHELIAL CARCINOMA EXPANSION COHORT: History of stroke, transient ischemic attack (TIA), or myocardial infarction, within months prior to CD History of stroke or transient ischemic attack within months prior to cycle , day Cerebrovascular event (transient ischemic attack, stroke or CNS bleeding) within the last months. History of stroke or transient ischemic attack within six months History of stroke or transient ischemic attack within months prior to study enrollment History of stroke or transient ischemic attack within months prior to day History of transient ischemic attack (TIA) or stroke within months of study entry Stroke within months of screening, or transient ischaemic attack (TIA) within months of screening History of arterial thrombosis (eg, stroke or transient ischemic attack) within months of first dose of AMG . History of transient ischemic attack within the previous months History of stroke or transient ischemic attack =< months prior to registration History of stroke or transient ischemic attack within six months History of stroke or transient ischemic attack within months prior to Day History of stroke or transient ischemic attack within months prior to study enrollment History of stroke or transient ischemic attacks within months prior to study enrolment. Patients are excluded if they have a history of stroke or transient ischemic attack within months prior to randomization History of stroke or transient ischemic attack within months prior to cycle , day History of stroke or transient ischemic attack within months History of stroke or transient ischemic attack within months prior to beginning treatment. History of stroke or transient ischemic attack, or other arterial thrombosis =< months prior to randomization Participants may not have had a history of a stroke or transient ischemic attack within six months Patients must have not have a history of hemorrhagic or ischemic stroke, including transient ischemic attacks and other central nervous system bleeding in the preceding months that were not related to glioma surgery Stroke or transient ischemic attack Myocardial infarction and transient ischemic attack or stroke within months prior to enrollment History of a stroke or transient ischemic attack within months - History of stroke or transient ischemic attack within months prior to Day . History of stroke or transient ischemic attack within months prior to day Clinical significant uncontrolled conditions \ active infection, myocardial infarction, stroke, or transient ischemic attack, psychiatric illness/social situations that would limit compliance. Prior history of stroke or transient ischemic attack within months prior to day - History of myocardial infarction, unstable angina, stroke, or transient ischemic attack within months prior to day Patients with a history of myocardial infarction, unstable angina, stroke, or transient ischemic attack (TIA) within months prior to planned day of dosing are ineligible History of stroke or transient ischemic attack History of stroke or transient ischemic attack within six months History of stroke or transient ischemic attack (TIA) within months prior to Cycle , Day History of stroke or transient ischemic attack within months prior to Day Past history of stroke or transient ischemic attack requiring medical therapy Symptomatic peripheral vascular disease, stroke or transient ischemic attack within months Patients with either of the following within months before the first dose of study treatment:\r\n* Stroke (including transient ischemic attack [TIA], or other ischemic event)\r\n* Myocardial infarction History of stroke or transient ischemic attack within months prior to registration History of stroke or transient ischemic attack within months prior to beginning treatment. History of stroke or transient ischemic attack within months prior to study enrollment History of stroke or transient ischemic attack within months prior to day History of stroke or transient ischemic attack within months of first study dose No history of stroke or transient ischemic attack History of stroke, reversible ischemic neurological defect or transient ischemic attack within months prior to Day History of cardiovascular disease including prior myocardial infarction, angina, stroke, or transient ischemic attack (TIA) History of progressive promyelocytic leukemia (PML), known history of pancreatitis, active grade or higher viral, bacterial or fungal infection =< weeks prior to registration and documented history of cerebrovascular event (stroke or transient ischemic attack [TIA]) =< months prior to registration Stroke or transient ischemic attack within months of screening History of stroke or transient ischemic attack in the preceding months History of stroke/transient ischemic attack