Patients with a history of current evidence/risk of retinal vein occlusion (RVO) or central serous retinopathy (CSR) Patients who meet any of the following exclusion criteria related to ocular disease will be excluded from study entry:\r\n* Known risk factors for ocular toxicity, consisting of any of the following:\r\n** History of serous retinopathy\r\n** History of retinal vein occlusion (RVO)\r\n** Evidence of ongoing serous retinopathy or RVO at screening History or current evidence/risk of retinal vein occlusion (RVO) History or current evidence of retinal vein occlusion or current risk factors for retinal vein occlusion (e.g., uncontrolled glaucoma or ocular hypertension, history of hyperviscosity or hypercoagulability syndromes) Patients must not have history of retinal vein occlusion (RVO) Patients with a previously documented retinal vein occlusion History or evidence of ongoing serous retinopathy or retinal vein occlusion (RVO) at baseline History or current evidence of retinal vein occlusion (RVO) or current risk factors for RVO. History of current evidence/risk of retinal vein occlusion (RVO) or retinal pigment epithelial detachment (RPED) in the eye unaffected by uveal melanoma; intra-ocular pressure (IOP) > mmHg or uncontrolled glaucoma History of prior or current retinal vein occlusion (RVO) Patients with a history or current evidence of CSR (central serous retinopathy), RVO (rential vein occlusion), or ophthalmopathy present at baseline that would be considered a risk factor for CSR or RVO A history of current evidence/risk of retinal vein occlusion (RVO) or central serous retinopathy (CSR) Ophthalmological conditions as follows:\r\n* Current or past history of retinal pigment epithelial detachment (RPED)/central serous retinopathy (CSR) or retinal vein occlusion\r\n* Uncontrolled glaucoma (irrespective of intraocular pressure [IOP]) Known history of retinal vein occlusion (RVO). History of serous retinopathy, retinal vein occlusion (RVO), or evidence of ongoing serous retinopathy or RVO at baseline History or current evidence of retinal vein occlusion (RVO) or current risk factors for RVO. History or current evidence of retinal vein occlusion (RVO) or current risk factors for RVO. Known risk factors for ocular toxicity, consisting of any of the following:\r\n* presence of serous retinopathy within months of protocol enrollment\r\n* presence of retinal vein occlusion (RVO) within months of protocol enrollment. STRATUM B: Participants with retinal vein occlusion (RVO) History of or evidence of retinal pathology on ophthalmologic examination that is considered a risk factor for neurosensory retinal detachment, retinal vein occlusion (RVO), or neovascular macular degeneration. Patients should be excluded if they have the following risk factors for RVO:\r\n* History of serous retinopathy.\r\n* History of retinal vein occlusion (RVO).\r\n* Evidence of ongoing serous retinopathy or RVO at baseline. History of retinal vein occlusion (RVO) History or current evidence/risk of retinal vein occlusion (RVO) Patients will be excluded if they currently have the following risk factors for retinal vein occlusion (RVO): () uncontrolled glaucoma with intra-ocular pressures >= mmHg () serum cholesterol >= grade () hypertriglyceridemia >= grade () hyperglycemia (fasting) >= grade Ophthalmological conditions as follows: current or past history of retinal pigment epithelial detachment (RPED)/central serous retinopathy (CSR) or retinal vein occlusion; or intraocular pressure (IOP) > mmHg or uncontrolled glaucoma (irrespective of IOP) Patients will not be eligible if they have a history of retinal vein or artery occlusion A history or current evidence of retinal vein occlusion (RVO) History of retinal vein occlusion (RVO) History or current evidence of retinal vein occlusion (RVO) or current risk factors for RVO. History or current evidence/risk of retinal vein occlusion (RVO) or central serous retinopathy (CSR) History or current evidence/risk of retinal vein occlusion (RVO) Ophthalmological conditions as follows: \r\n Intra-ocular pressure > mmHg, or uncontrolled glaucoma (irrespective of intra-ocular pressure) \r\n Current or past history of central serous retinopathy or retinal vein occlusion A history of retinal vein occlusion (RVO) History of retinal vein occlusion (RVO) Patients with the following ophthalmological findings/conditions:\r\n* Intraocular pressure > mmHg, or uncontrolled glaucoma (irrespective of intraocular pressure)\r\n* Current or past history of central serious retinopathy or retinal vein occlusion History or current evidence of central serous retinopathy (CSR), retinal vein occlusion (RVO) History or current evidence/risk of retinal vein occlusion (RVO) History or current evidence of central serous retinopathy (CSR) or retinal vein occlusion (RVO) Ophthalmological conditions as follows:\r\n* Intra-ocular pressure > mmHg, or uncontrolled glaucoma (irrespective of intra-ocular pressure)\r\n* Current or past history of central serous retinopathy or retinal vein occlusion History of or current evidence / risk of retinal vein occlusion (RVO) central serous retinopathy (CSR), or glaucoma with intraocular pressures ? mmHg or other pre-existing ocular conditions that may put the patient at risk for ocular toxicities A history of retinal vein occlusion (RVO) or risks factors for RVO Ophthalmologic conditions, including any of the following:\r\n* Current or past history of central serous retinopathy\r\n* Current or past history of retinal vein occlusion\r\n* Intraocular pressure (IOP) > mmHg or uncontrolled glaucoma History of retinal vein occlusion (RVO) History of retinal vein occlusion (RVO) History of retinal vein occlusion (RVO) Known ophthalmological conditions as follows: intra-ocular pressure > mmHg, or uncontrolled glaucoma (irrespective of intra-ocular pressure); current or past history of central serous retinopathy or retinal vein occlusion History of retinal vein occlusion (RVO) History or current evidence/risk of retinal vein occlusion (RVO) Patient must not have a history of retinal vein occlusion (RVO) CLINICAL/LABORATORY CRITERIA: Patients must not have untreated or unresolved retinopathy or have a history (or current evidence) of retinal vein occlusion determined by an ophthalmology exam within days prior to registration Patients with a history or current evidence/risk of retinal vein occlusion (RVO) History of predisposition to retinal vein occlusion or central serous retinopathy History of predisposition to retinal vein occlusion or central serous retinopathy History of retinal vein occlusion (RVO) History of retinal vein occlusion Has a history of, or current, retinal vein occlusion (RVO) or current risk factors for RVO History of or current evidence of central serous retinopathy (CSR), retinal vein occlusion (RVO) or history of retinal degenerative disease Patients with a history or current known evidence of central serous retinopathy (CSR), retinal vein occlusion (RVO) or ophthalmopathy at baseline that would be considered a risk factor for CSR or RVO A history or current evidence/risk of retinal vein occlusion or central serous retinopathy History of or current evidence of retinal vein occlusion (RVO) or risk factors of RVO History of retinal vein occlusion (RVO) History or current evidence of retinal vein occlusion (RVO) or central serous retinopathy (CSR) History or current evidence/risk of retinal vein occlusion (RVO) or central serous retinopathy (CSR) A history or current evidence of retinal vein occlusion (RVO). History or current evidence/risk of retinal vein occlusion (RVO) History of central serous retinopathy or retinal vein occlusion Patients with baseline risk factors for central serous retinopathy or retinal vein occlusion such as evidence of new optic disc cupping, evidence of new visual field defects, and intraocular pressure > mmHg History or current evidence/risk of retinal vein occlusion (RVO) Evidence of a retinal vein occlusion on ophthalmological exam or a history of retinal vein occlusion History or current evidence of retinal vein occlusion (RVO) or central serous retinopathy (CSR). Predisposing factors to retinal vein occlusion (RVO) A history or current evidence/risk of retinal vein occlusion or central serous retinopathy History of or current risk for retinal vein occlusion (RVO) or central serous retinopathy (CSR) History or current evidence/risk of retinal vein occlusion (RVO) or retinal pigment epithelial detachment (RPED) in the eye unaffected by uveal melanoma A history or current evidence/risk of retinal vein occlusion (RVO) or Central serous retinopathy (CSR) including History or concurrent evidence of retinal vein occlusion (RVO) or current risk factors for RVO. History of or current evidence of retinal vein occlusion (RVO). History of retinal vein occlusion, central serous retinopathy or glaucoma. History or current evidence/risk of retinal vein occlusion (RVO)