History of congestive heart failure No congestive heart failure (CHF) within days of registration History of congestive heart failure or myocardial infarction < year prior to first study dose administration Active congestive heart failure or ventricular arrhythmia requiring medication Congestive heart failure History of active myocardial ischemia, cardiomyopathy, uncontrolled dysrhythmia, or congestive heart failure within the last months before enrollment Must not have a serious heart condition, such as congestive heart failure, unstable angina pectoris, or heart attack within the last three months Symptomatic congestive heart failure History of myocardial infarction or decompensated congestive heart failure (CHF) within the last months Congestive heart failure (CHF) since axitinib can cause CHF History of pulmonary edema or decompensated congestive heart failure with in six () week of enrollment. History or presence of myocardial infarction, clinically relevant valvular heart disease, or congestive heart failure within the last months; Symptoms of congestive heart failure or uncontrolled cardiac rhythm disturbance Current symptomatic congestive heart failure or history of symptomatic congestive heart failure in the preceding months, defined as New York (NY) Heart Association classification - Presence of any serious concomitant systemic disorders incompatible with the study in the opinion of the investigator (e.g., uncontrolled congestive heart failure, active infection, etc.); Patients with history of congestive heart failure stage III or greater For participants with congestive heart failure, cardiovascular-related hospitalizations within weeks prior to randomization Patients with history of congestive heart failure stage III or greater Symptomatic congestive heart failure Been treated with appropriate maximal medical therapy for heart failure Patients with history of congestive heart failure are excluded Unstable angina and/or congestive heart failure requiring hospitalization within the last months Subject with significant congestive heart failure (CHF) or history of CHF, chronic renal failure, hepatic failure, neuropathy Significant history of a medical problem or co-morbidity that would preclude the patient from undergoing a major abdominal operation such as a history of severe congestive heart failure or active ischemic heart disease Previous hospitalization due to documented heart failure in the last months Congestive heart failure < months prior to screening Presence of a symptomatic bradyarrhythmia or uncompensated heart failure Congestive heart disease not controlled by medication. Congestive heart failure (CHF) within months prior to first dose; No acute congestive heart failure Uncontrolled congestive heart failure or angina Subjects with uncontrolled (over the last days) clinically significant confounding medical conditions such as congestive heart failure Current clinical heart failure or symptomatic ischemic heart disease History of myocardial infarction =< months, or current symptomatic congestive heart failure or left ventricular ejection fraction (LVEF) < % or with > grade diastolic dysfunction, with no symptoms or signs of heart failure Must not have a serious heart condition, such as congestive heart failure, unstable angina pectoris, or heart attack within the last three months Congestive heart failure requiring medication (other than diuretic) Uncontrolled ischemic heart disease, or uncontrolled symptomatic congestive heart failure Active ischemic heart disease or congestive heart failure Been treated with appropriate maximal medical therapy for heart failure Subjects with clinically significant active ischemic heart disease, cardiac muscle disease (including cardiomyopathy or congestive heart failure) or myodegenerative disorders that may affect safe study participation Unstable angina and/or congestive heart failure requiring hospitalization within months prior to step registration Serious intercurrent medical illness (e.g., symptomatic congestive heart failure) Has a history of significant congestive heart failure or significant pulmonary disease Within days of registration: Absence of clinical decompensated congestive heart failure or uncontrolled arrhythmia Symptomatic congestive heart failure (CHF) Absence of clinically significant cardiomyopathy, congestive heart failure No decompensated congestive heart failure (CHF), or uncontrolled arrhythmia; ejection fraction (EF) >= % Absence of clinically significant cardiomyopathy, congestive heart failure Previous history of congestive heart failure Cerebrovascular or cardiovascular event, or congestive heart failure within the last months. Active congestive heart failure or ventricular arrhythmia requiring medication Significant cardiovascular disease (including congestive heart failure). Unstable angina and/or congestive heart failure requiring hospitalization within the last months No congestive heart failure < months Uncontrolled ischemic heart disease or uncontrolled symptomatic congestive heart failure Echocardiogram (ECHO) cardiogram and cardiology consultation required within days prior to registration for patients with a history of congestive heart failure or cardiovascular disease or history of exposure to cardiotoxic agents who are not already excluded Known active symptomatic congestive heart failure Patients with symptoms of congestive heart failure are not eligible No Symptomatic Congestive Heart Failure (Ejection Fraction EF ? %) Uncontrolled ischemic heart disease or uncontrolled symptomatic congestive heart failure History of congestive heart failure or other findings of ventricular dysfunction Symptomatic congestive heart failure Uncontrolled ischemic heart disease or uncontrolled symptomatic congestive heart failure The participant has symptomatic congestive heart failure (CHF), left ventricular dysfunction (LVEF < %), severe myocardial insufficiency, cardiac arrhythmia, or cardiomyopathy. Known congestive heart failure requiring medical management History of congestive heart failure or systolic dysfunction (LVEF <%) History of symptomatic congestive heart failure within months prior to the initiation of therapy on this protocol Congestive heart failure (CHF) within months prior to first dose Evidence of uncontrolled congestive heart failure Symptomatic congestive heart failure History of congestive heart failure (CHF) Has symptomatic congestive heart failure (CHF) The patient has a history of uncontrolled angina, arrhythmias, or congestive heart failure Patients must not have unstable angina or NYHA classification of congestive heart failure of grade >= No decompensated congestive heart failure (CHF), or uncontrolled arrhythmia Uncompensated congestive heart failure Grade or greater congestive heart failure History of hospitalization for Congestive Heart Failure History of heart disease History of heart disease. Patients with the clinical diagnosis of congestive heart failure or angina pectoris are NOT eligible Severe cardiovascular disease, i.e., arrhythmias requiring chronic treatment, congestive heart failure or symptomatic ischemic heart disease Patients cannot have known cardiac disease (either arrhythmia or congestive heart failure) requiring treatment Clinically significant and/or uncontrolled heart disease such as congestive heart failure (CHF) requiring treatment (NYH grade ?), hypertension or arrhythmia Serious intercurrent medical illness (e.g., symptomatic congestive heart failure) Patients with congestive heart failure or significant arrhythmia Has a medical history of symptomatic Congestive Heart Failure (CHF) (NYHA classes II-IV) or serious cardiac arrhythmia. Symptomatic congestive heart failure Uncontrolled arrhythmia or heart failure Congestive heart failure. History of symptomatic congestive heart failure or serious cardiac arrhythmia requiring treatment History of congestive heart failure; Patients with history of congestive heart failure Symptomatic congestive heart failure History of congestive heart failure (CHF) Active symptomatic congestive heart failure Congestive heart failure (CHF) currently requiring therapy Active congestive heart failure or ventricular arrhythmia Symptomatic congestive heart failure; Congestive heart failure (CHF) currently requiring therapy No evidence of clinically significant congestive heart failure, (ejection fraction of % or greater) Has an active infection, congestive heart failure, slow heart rate, or other uncontrolled disease other than cancer Active heart disease Unstable congestive heart failure History or current symptoms of congestive heart failure (shortness of breath, ankle swelling) Clinical diagnosis of congestive heart failure and/or pulmonary capillary wedge pressure > mmHg, or uncorrected congenital heart disease. Congestive heart failure, Unstable angina or uncontrolled congestive heart failure Active symptomatic congestive heart failure Congestive heart failure requiring medication (other than diuretic) Heart failure exacerbation at the time of study enrollment. History of or active ventricular dysrhythmias or congestive heart failure requiring medication or symptomatic coronary heart disease Unstable angina and/or congestive heart failure requiring hospitalization within the last months prior to registration. Extremity edema due to heart failure Patients with history of congestive heart failure Uncontrolled heart failure in the last week Congestive heart failure Congestive heart failure Receiving treatment for cardiomyopathy or congestive heart failure History of congestive heart failure and ejection fraction less than % History of congestive heart failure; systolic heart failure defined as ejection fraction (EF) =< %, or diastolic heart failure defined as EF > % PLUS systemic manifestation of heart failure Congestive heart failure (CHF) Patients with history of congestive heart failure Congestive heart failure or documented cardiomyopathy with an EF ?%, provided that EF ?% or, No significant history of a medical problem or co-morbidity that would preclude the patient from undergoing a major abdominal operation such as a history of severe congestive heart failure or active ischemic heart disease Unstable angina or uncontrolled congestive heart failure Documentation of congestive heart failure and ejection fraction < % if recorded in the pre-operative record Heart failure exacerbation at the time of enrollment Heart failure exacerbation at the time of study enrollment Any patient with known ischemic heart disease, history of congestive heart failure, history of stroke, or cardiac arrhythmia for which the patient requires medication or a medical device Congestive heart failure refractory to medical management Receiving treatment for cardiomyopathy or heart failure NYHA stage or congestive heart failure Known heart disease Known heart disease History of myocardial disease, such as myocarditis, cardiomyopathy, congestive heart failure, ischemic cardiomyopathy Patients with congestive heart failure requiring pharmacological management Participant reported history of congestive heart failure Congestive heart failure Liver impairment or congestive heart failure Has an active infection (e.g., pneumonia), congestive heart failure, bradyarrhythmia, any uncontrolled disease (e.g., diabetic ketoacidosis, gastrointestinal obstruction) except for malignancy congestive heart failure uncontrolled symptomatic heart failure, History of renal disease, hypertension, diabetes, congestive heart failure or emphysema > stage heart failure Worsening of or clinically unstable congestive heart failure Congestive heart failure, clinically significant History of congestive heart failure History of clinically significant congestive heart failure Participants with history of hypertension, congestive heart failure, edema, stroke or other cardiac disease or condition Patients with history of congestive heart failure Symptomatic congestive heart failure. Men who have contraindications to exercise based the American College of Sports Medicine Exercise pre-participation screening criteria and who do not receive a physician clearance to participate in the moderate intensity physical activity with one or more of the following self-reported conditions:\r\n* heart attack\r\n* heart surgery, cardiac catherization, or coronary angioplasty\r\n* pacemaker/implantable cardiac defibrillator/rhythm disturbance\r\n* heart valve disease \r\n* heart failure \r\n* heart transplantation \r\n* congenital heart disease \r\n* diabetes \r\n* kidney (renal) disease\r\n* chest discomfort with exertion \r\n* unreasonable breathlessness \r\n* dizziness, fainting or blackouts \r\n* ankle swelling \r\n* unpleasant awareness of forceful, rapid or irregular heart rate \r\n* burning or cramping sensations in your lower legs when walking short distance Other clinically significant heart disease (e.g. congestive heart failure, cardiomyopathy or uncontrolled hypertension) Unstable angina and/or congestive heart failure requiring hospitalization within the last months History of heart disease