Have had recent major surgery within a minimum weeks prior to starting study treatment; minor surgeries such as surgical placement for vascular access are not exclusionary Major surgery within weeks of starting study treatment; there is no minimum time requirement for minor procedures such as biopsy or vascular access placement Have had recent major surgery within a minimum of weeks prior to starting study treatment, with the exception of surgical placement for vascular access Recent major surgery within weeks prior to starting study treatment, with the exception of surgical placement for vascular access Have had recent major surgery within a minimum of weeks prior to starting study treatment, with the exception of surgical placement for vascular access Major surgery within days of starting study treatment; there is no minimum time requirement for minor procedures such as biopsy or vascular access placement Recent major surgery within a minimum of weeks prior to starting study treatment, with the exception of surgical placement for vascular access Major surgery within days of starting study treatment; there is no minimum time requirement for minor procedures such as biopsy or vascular access placement