Absolute neutrophil count (ANC) >= /mm^, independent of growth factor support, documented within days of registration Absolute neutrophil count (ANC) > , cells/dL (. x e/L) (growth factor cannot be used within the previous days) Absolute neutrophil count >= . x ^/L within days of treatment initiation and must be independent of hematopoietic growth factor support Absolute neutrophil count ?,/mm without growth factor use ? days prior to treatment (cycle day , CD) Absolute neutrophil count (ANC) >= /uL (with/without growth factor) Absolute neutrophil count (ANC) >= . x ^/L without growth factor support, at the screening visit Absolute neutrophil count (ANC) >= . x ^/L without growth factor support Absolute neutrophil count (ANC): >= /mm^, must be at least days after last dose of growth factor Absolute neutrophil count >= ,/mcL without growth factor support, =< days prior to CD Absolute neutrophil count > /mm^ without the support of growth factors Absolute neutrophil count (ANC) >= , cell/mm^ without growth factor support, obtained =< days prior to registration Absolute neutrophil count (ANC) ? /uL, with or without chronic granulocyte growth factor support STRATUM A: Absolute neutrophil count (ANC) >= /mm^ without growth factor support within days of the test Absolute neutrophil count (ANC) >= /mm^ independent of growth factor support Absolute neutrophil count ? /mcL, and have not received any growth factor support for at least weeks prior to screening To be performed within days prior to day of protocol therapy: Absolute neutrophil count (ANC) >= ,/mm^\r\n* NOTE: growth factor support is not permitted to normalize baseline ANC parameters, however subsequent growth factor administration is permitted as standard supportive care Absolute neutrophil count (ANC) > ,/mm^ independent of growth factor support Absolute neutrophil counts of >= /uL (without growth factor support) results within days before study drug administration Absolute neutrophil count (ANC) >= . x ^/L in absence of growth factor support Absolute neutrophil count (ANC) >= /ul in the absence of growth factor support unless due to compromised bone marrow production from CLL, indicated by >= % CLL in marrow Absolute neutrophil count (ANC) < ,/mm without growth factor support within days prior to testing Participants with an absolute neutrophil count (ANC) >= /mm^, within days of initiation of protocol therapy; growth factor within days of screening is not allowed to meet ANC eligibility criteria Participants with an absolute neutrophil count (ANC) < /mm^, within days of initiation of protocol therapy; growth factor within days of screening is not allowed to meet ANC eligibility criteria Absolute neutrophil count (ANC) >= ,/mm^ without transfusion or growth factor support for at least week Absolute neutrophil >= ,/mcL; transfusion and/or growth factor are permitted within any timeframe Obtained =< days prior to registration: Absolute neutrophil count (ANC) >= , cell/mm^ without growth factor support Within days prior to planned start of treatment: Absolute neutrophil count (ANC) >= /mm^\r\n* Growth factor is not permitted within days of ANC assessment unless cytopenia is secondary to disease involvement Absolute neutrophil count >= ,/mcL (without growth factor support) Absolute neutrophil count >= /mcL (in the absence of growth factor support), within days prior to treatment Absolute neutrophil count (ANC) >= /mm^ independent of growth factor support Absolute neutrophil count >= ,/mcL, regardless of transfusion or growth factor support Absolute neutrophil count (ANC) ? . K/mm^ (must be stable off any growth factor within weeks of first study drug administration) Absolute neutrophil count (ANC) >= . x ^/L without daily use of myeloid growth factor PART GROUP INCLUSION CRITERIA: Peripheral absolute neutrophil count (ANC) >= /mm^ (. x ^/L) without granulocyte growth factor for >= days PHASE I: Absolute neutrophil count >= ,/mcL without growth factor support PHASE II SCLC: Absolute neutrophil count >= ,/mcL without growth factor support UROTHELIAL CARCINOMA EXPANSION COHORT: Absolute neutrophil count >= ,/mcL without growth factor support mCRPC EXPANSION COHORT: Absolute neutrophil count >= ,/mcL without growth factor support Absolute neutrophil count >= cells/mm^, with or without transfusion support; NOTE: If the patients bone marrow biopsy shows greater than or equal to % plasma cells, absolute neutrophil count (ANC) > cells/mm^ (transfusion support or growth factor support is acceptable) Absolute neutrophil count (ANC) >= ,/mcL with no growth factor support in the previous weeks Absolute neutrophil count (ANC) >= , cells/ul without growth factor support Absolute neutrophil count >= ,/mm^ without growth factor use =< days prior to CD Absolute neutrophil count (ANC) >= /mm^; growth factor is not permitted within days of neutrophil assessment Absolute neutrophil count (ANC) >= /mm^ or >= /mm^ in the setting of marrow involvement by disease (independent of growth factor or transfusion support) Absolute neutrophil count (ANC) ? /mm, independent of growth factor support; Absolute neutrophil count (ANC) /cu mm (off myeloid growth factors) Absolute neutrophil count (ANC) >= ,/mm^ without growth factor support Absolute neutrophil count >= . x ^ cells/L (growth factor use is allowed) Absolute neutrophil count >= ,/mcL (without growth factor support) Absolute neutrophil count >= . K/mcL, without use of growth factor support for week Obtained =< days prior to registration: Absolute neutrophil count (ANC) >= /uL (without growth factor support) Absolute neutrophil count (ANC) >= . x ^/L; screening ANC should be independent of growth factor support for over one week for all patients Received growth factor support or transfusions to achieve hematology entry criteria (platelets, hemoglobin, absolute neutrophil count) Absolute neutrophil count (ANC) >/= , cells/ul without growth factor support prior to initial treatment Within days prior to day of protocol therapy unless otherwise stated: Absolute neutrophil count (ANC) >= ,/mm^\r\n* NOTE: Growth factor is not permitted within days of ANC assessment unless cytopenia is secondary to disease involvement Absolute neutrophil count (ANC) >= ,/mm^ (without transfusion or growth factor support) To be performed within days prior to day of protocol therapy: Absolute neutrophil count (ANC) >= /mm^\r\n* NOTE: Growth factor is not permitted within days of ANC assessment unless cytopenia is secondary to disease involvement Obtained within days (or as stipulated) prior to study drug (treatment) administration: absolute neutrophil count (ANC) ? cells/ul (growth factor cannot be used within the previous days) Absolute neutrophil count (ANC) >= . x ^/L without growth factor support Absolute neutrophil count (ANC) >= , cell/mm^ without growth factor support within days prior to registration Participants with an absolute neutrophil count (ANC) < /mm^, within days of initiation of protocol therapy; growth factor within days of screening is not allowed to meet ANC eligibility criteria Evidence of myeloid engraftment (eg, absolute neutrophil count ? . ^/L for consecutive days if ablative therapy was previously used). Use of growth factor supplementation is allowed. Absolute neutrophil count (ANC) < , cells/mm^ within days of initiation of protocol therapy; growth factor administration is not allowed to meet ANC eligibility criteria Absolute neutrophil count (ANC) >= /ul (without growth factor support) Within days prior to randomization: Absolute neutrophil count (ANC) >= cells/mcL (. x ^/L); hence ANC must be >= /mcL without myeloid growth factor support Absolute neutrophil count (ANC) ? . x ^/uL without treatment with a myeloid growth factor within days prior to first dose of IP Absolute neutrophil count (ANC) >= . x ^/L without growth factor support Within days prior to registration: Absolute neutrophil count (ANC) >= , cells/mm^ without growth factor support Absolute Neutrophil Count (ANC) ? . x /L without growth factor support for days ( days if received pegfilgrastim). Absolute neutrophil count (ANC) ? . x ^/L in the absence of growth factor in the prior days Within h of initiating study treatment: Absolute neutrophil count (ANC) >= /mm^; Note: transfusions of blood and blood products as well as growth factor support are prohibited within days prior to the first dose of study treatment Absolute neutrophil count (ANC) >= . x ^ /L, independent of growth factor support unless with bone marrow involvement for days Within days prior to signing informed consent: Absolute neutrophil count (ANC) >= ,/mm^, independent of growth factor support Absolute neutrophil count >= ,/mcL without growth-factor support during the past month Absolute neutrophil count (ANC) ? /mm (screening ANC should be independent of growth factor support for ? week) Participants with an absolute neutrophil count (ANC) < cells/mm^ at time of screening evaluation; growth factor may not be used to meet ANC eligibility criteria within days of obtaining screening evaluation Absolute neutrophil count >= . x ^ cells/L (growth factor use is allowed) Absolute neutrophil count (ANC) > . x ^/L in the absence of growth factor in the prior days At least weeks ( days) prior to registration: Absolute neutrophil count (ANC) >= . x ^/L without growth factor support Absolute neutrophil count (ANC) >= . ^/L (without transfusion support and without hematological growth factor support within weeks of cycle day ) Participants with an absolute neutrophil count (ANC) < cells/mm^ at time of screening evaluation; growth factor may not be used to meet ANC eligibility criteria within days of obtaining screening evaluation Absolute neutrophil count (ANC) >= . x ^ /L. No transfusion or growth factor support for one week prior to labs. Absolute neutrophil count >= ,/mcL in the absence of growth factor administration Absolute neutrophil count (ANC) >= /ul (without growth factor support) Neutrophils < . x ^/L (neutrophil count should be > without growth factor support, unless neutropenia is caused by anti-neutrophil antibodies or other manifestation of chronic GVHD) Absolute neutrophil count (ANC) > , (growth factors permitted) Absolute neutrophil count (ANC) >= . x ^/L (growth factors not permitted to make eligible) Absolute neutrophil count (ANC) equal or greater to without growth factor support for at least days Absolute neutrophil count (ANC) >= , cells/mm^ (without platelet transfusion or myeloid growth factor support within two weeks of screening) Absolute neutrophil count (ANC) >= cells/mm without growth factor support Absolute neutrophil count >= ,/mcL*\r\n* Participants may be receiving growth factor support to meet these criteria Absolute neutrophil count >= . K/uL (growth factor support is permissible) Peripheral absolute neutrophil count (ANC) >= /mm^; \r\n* Note: must be > days from use of hematopoietic growth factor or days from pegfilgastrim Absolute neutrophil count (ANC) < ,/mm without growth factor support within days prior to testing Absolute neutrophil count >=, per cubic millimeter (/mm^), not supported by growth factor Absolute Neutrophil count (ANC) ? . x /L without daily use of myeloid growth factor; and Absolute neutrophil count (ANC) >= /mm^ (. x ^/L) (participants receiving transfusion, erythropoietin, or myeloid growth factor support will be eligible for this study) Absolute neutrophil count (ANC) ? /mm within days prior to randomization. Screening ANC should be independent of growth factor support for ? week. Absolute neutrophil count (ANC) >= , cells/dL (. x ^/L) (growth factors cannot be used within days of first drug administration) Absolute neutrophil count >= ,/mcL independent of growth factor support Absolute neutrophil count >= . x ^/L (without growth factor support) Absolute neutrophil count (ANC) >= . x ^/L (growth factor support is allowed to reach this goal) Absolute neutrophil count (ANC) >= . x ^/L without growth factor support Absolute neutrophil count >= cells/mm^ (. x ^/L); growth factor allowed to achieve Absolute neutrophil count (ANC) >= /ul without growth factor or transfusional support Absolute neutrophil count (ANC) >= /ul without growth factor or transfusional support Subjects must have the following laboratory values: Absolute Neutrophil Count (ANC) ? . x /L without growth factor support for days ( days if subject received pegfilgrastim). Absolute neutrophil count (ANC) >= . X ^/L without (w/o) myeloid growth factor support for days preceding lab assessment, obtained within days prior to PET scan Absolute neutrophil count (ANC) ?. x /L (in absence of growth factor support)