Clinically significant (ie, active) cardiovascular disease: cerebral vascular accident/stroke (< months prior to enrollment), myocardial infarction (<  months prior to enrollment), unstable angina, congestive heart failure, or serious cardiac arrhythmia requiring medication.
Clinically significant (i.e., active) cardiovascular disease: cerebral vascular accident/stroke (<  months prior to enrollment), myocardial infarction (<  months prior to enrollment), unstable angina, congestive heart failure (>= New York Heart Association Classification Class II), or serious cardiac arrhythmia requiring medication
Significant cardiovascular disease (New York Heart Association Class II or greater), myocardial infarction within the  months prior to study entry, unstable angina, or cerebral vascular accident / stroke (<  months prior to enrollment), or serious uncontrolled cardiac arrhythmia requiring medication / active intervention, corrected QT interval [QTc] prolongation of > ms and/or prior diagnosis of congenital long QT syndrome.
Uncontrolled or significant cardiovascular disease, including any of the following:\r\n* Symptomatic congestive heart failure (>= New York Heart Association Classification class II)\r\n* Cerebral vascular accident/stroke (<  months prior to enrollment), myocardial infarction (<  months prior to enrollment), or unstable angina\r\n* Uncontrolled hypertension or uncontrolled cardiac arrhythmia
PHASE II EXCLUSION CRITERIA: Uncontrolled or significant cardiovascular disease, including any of the following:\r\n* Symptomatic congestive heart failure (>= New York Heart Association Classification class II)\r\n* Cerebral vascular accident/stroke (<  months prior to enrollment), myocardial infarction (<  months prior to enrollment), or unstable angina\r\n* Uncontrolled hypertension or uncontrolled cardiac arrhythmia
Within  months prior to study drug administration, clinically significant cardiovascular/cerebrovascular disease defined as follows: cerebral vascular accident/stroke, myocardial infarction, unstable angina, congestive heart failure (New York Heart Association classification class >= II), bleeding or pulmonary embolism or cardiac arrhythmias that was severe enough to cause hemodynamic compromise
Clinically significant (i.e., active) cardiovascular disease: cerebral vascular accident/stroke <  months prior to enrollment, myocardial infarction <  months prior to enrollment, unstable angina, congestive heart failure (>= New York Heart Association [NYHA] III) or serious cardiac arrhythmia requiring medication
Clinically significant cardiovascular/cerebrovascular disease as follows: cerebral vascular accident/stroke (<  months prior to enrollment), myocardial infarction (<  months prior to enrollment), unstable angina, congestive heart failure (New York Heart Association classification class > II), or serious cardiac arrhythmia.
Clinically significant (i.e., active) cardiovascular disease: cerebral vascular accident/stroke (<  months prior to enrollment), myocardial infarction (<  months prior to enrollment), unstable angina, congestive heart failure (>= New York Heart Association classification class II), or serious cardiac arrhythmia requiring medication; patients with stable rate-controlled atrial fibrillation will be allowed to participate
Clinically significant cardiovascular/cerebrovascular disease as follows: cerebral vascular accident/stroke (<  months prior to enrollment), myocardial infarction (<  months prior to enrollment), unstable angina, congestive heart failure (New York Heart Association Classification class >= II), or serious cardiac arrhythmia
Clinically significant (i.e., active) cardiovascular disease: cerebral vascular accident/stroke (<  months prior to enrollment), myocardial infarction (<  months prior to enrollment), unstable angina, congestive heart failure (>= New York Heart Association classification class II), or serious cardiac arrhythmia requiring medication
Clinically significant cardiovascular/ cerebrovascular disease as follows: cerebral vascular accident / stroke (<  months prior to enrollment), myocardial infarction (<  months prior to enrollment), unstable angina, congestive heart failure (New York Heart Association Classification class > II), or serious cardiac arrhythmia.
Clinically significant (i.e., active) cardiovascular disease: acute cerebral vascular accident/stroke (<  months prior to enrollment) excluding transient ischemic attack (TIA), myocardial infarction (<  months prior to enrollment), unstable angina, congestive heart failure (>= New York Heart Association classification class II), or serious cardiac arrhythmia requiring medication.
Clinically significant (i.e., active) cardiovascular disease: cerebral vascular accident / stroke (<  months prior to enrollment), myocardial infarction (<  months prior to enrollment), unstable angina, congestive heart failure (>= New York Heart Association Classification class II), or serious cardiac arrhythmia requiring medication
Clinically significant (i.e., active) cardiovascular disease: cerebral vascular accident/stroke (<  months prior to enrollment), myocardial infarction (<  months prior to enrollment), unstable angina, congestive heart failure (? New York Heart Association Classification class II), or serious cardiac arrhythmia requiring medication
Uncontrolled intercurrent illness including, but not limited to, clinically significant (i.e. active) cardiovascular disease: cerebral vascular accident/stroke (<  months prior to enrollment), myocardial infarction (<  months prior to enrollment), congestive heart failure (>= New York Heart Association [NYHA] class II), unstable angina pectoris, or serious cardiac arrhythmia requiring medication
Clinically significant cardiovascular / cerebrovascular disease as follows: cerebral vascular accident / stroke (<  months prior to enrollment), myocardial infarction (<  months prior to enrollment), unstable angina, congestive heart failure (New York Heart Association classification class >= II), serious cardiac arrhythmia, clinically significant bleeding or clinically significant pulmonary embolism
Clinically significant (i.e., active) cardiovascular disease: cerebral vascular accident/stroke (<  months prior to enrollment), myocardial infarction (<  months prior to enrollment), unstable angina, congestive heart failure (>= New York Heart Association classification class II), or serious cardiac arrhythmia requiring medication.
Clinically significant (i.e., active) cardiovascular disease: cerebral vascular accident/stroke (<  months prior to enrollment), myocardial infarction (<  months prior to enrollment), unstable angina, congestive heart failure (? New York Heart Association Classification class II), or serious cardiac arrhythmia requiring medication
Clinically significant (i.e. active) cardiovascular disease: cerebral vascular accident (<  months prior to enrollment), myocardial infarction (<  months prior to enrollment), unstable angina, congestive heart failure (>= New York Heart Association Classification class II), or serious cardiac arrhythmia requiring medication
Clinically significant (i.e., active) cardiovascular disease: cerebral vascular accident/stroke (<  months prior to enrollment), myocardial infarction (<  months prior to enrollment), unstable angina, congestive heart failure (>= New York Heart Association classification class II), or serious cardiac arrhythmia requiring medication
Clinically significant (i.e., active) cardiovascular disease: cerebral vascular accident/stroke (<  months prior to enrollment), myocardial infarction (<  months prior to enrollment), unstable angina, congestive heart failure (>= New York Heart Association Classification class II), or serious cardiac arrhythmia requiring medication
Clinically significant cardiovascular disease including cerebral vascular accident/stroke (<  months prior to enrollment), myocardial infarction (<  months prior to enrollment), congestive heart failure with New York Heart Association (NYHA) class II or greater or serious cardiac arrhythmia requiring medication
Clinically significant (i.e., active) cardiovascular disease: cerebral vascular accident/stroke (<  months prior to enrollment), myocardial infarction (<  months prior to enrollment), unstable angina, congestive heart failure (>= New York Heart Association Classification class II), or serious cardiac arrhythmia requiring medication
Clinically significant (i.e., active) cardiovascular disease: cerebral vascular accident/stroke (<  months prior to enrollment), myocardial infarction (<  months prior to enrollment), unstable angina, congestive heart failure (>= New York Heart Association Classification class II), or serious cardiac arrhythmia requiring medication
Clinically significant (i.e., active) cardiovascular disease: cerebral vascular accident/stroke (<  months prior to enrollment), myocardial infarction (<  months prior to enrollment), unstable angina, congestive heart failure (New York Heart Association [NYHA] class >= II), or serious uncontrolled cardiac arrhythmia
Clinically significant (active) cardiovascular disease: cerebral vascular accident/stroke or myocardial infarction within  months prior to study enrollment; unstable angina, congestive heart failure or a serious cardiac arrhythmia requiring medication.
Clinically significant (that is, active) cardiovascular disease: cerebral vascular accident / stroke (<  months prior to enrollment), myocardial infarction (<  months prior to enrollment), unstable angina, congestive heart failure (New York Heart Association Classification Class >= II), or serious cardiac arrhythmia requiring medication
Clinically significant (i.e., active) cardiovascular disease: cerebral vascular accident/stroke (<  months prior to enrollment), myocardial infarction (<  months prior to enrollment), unstable angina, congestive heart failure (>= New York Heart Association Classification class II), or serious cardiac arrhythmia requiring medication
Clinically significant cardiovascular disease: cerebral vascular accident/stroke or myocardial infarction within  months prior to study entry; unstable angina, congestive heart failure or a serious cardiac arrhythmia requiring medication.
Clinically significant (i.e., active) cardiovascular disease: cerebral vascular accident/stroke (< months before enrollment), myocardial infarction (< months before enrollment), unstable angina, congestive heart failure (New York Heart Association class ?II), or serious uncontrolled cardiac arrhythmia requiring medication.
Clinically significant (i.e., active) cardiovascular disease: cerebral vascular accident/stroke (<  months prior to enrollment), myocardial infarction (<  months prior to enrollment), unstable angina, congestive heart failure (>= New York Heart Association Classification class II), or serious cardiac arrhythmia requiring medication
Clinically significant (i.e., active) cardiovascular disease: cerebral vascular accident/stroke (<  months prior to enrollment), myocardial infarction (<  months prior to enrollment), unstable angina, congestive heart failure (>= New York Heart Association Classification class II), or serious cardiac arrhythmia requiring medication
Clinically significant (i.e., active) cardiovascular disease: cerebral vascular accident/stroke (<  months prior to enrollment), myocardial infarction (<  months prior to enrollment), unstable angina, congestive heart failure (>= New York Heart Association classification class II), or serious cardiac arrhythmia requiring medication